Abstract: A 3-D (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. A filler mechanism that fills the customized matrix with one or more filler materials. The one or more filler materials retained within the customized matrix are cured or solidified to produce the object.

Abstract: Disclosed are methods and devices for platelet function analysis. An impedance-based micro platelet function test device comprises a pair of micro-fabricated 3D electrodes for measuring an electrical impedance between the pair electrodes during a platelet function test, and a microfluidic chamber enclosing the pair of electrodes. At least one of the electrodes comprises an electrode core coated with a metal coating, the metal coating has a patterned surface structure derived from a patterned surface of the electrode core, and the microfluidic chamber has an inlet for accepting a blood sample comprising platelets for the platelet function test. The measured electrical impedance characterizes platelet aggregation in the blood sample. Such micro platelet function test methods and devices provide a low-cost, micro electrical-mechanical system based testing platform that enable accurate and repeatable platelet function analyses.

Abstract: Apparatus, systems, and methods are provided for assessing clot activity in blood under various conditions in vitro. The apparatus includes a plurality of test receptacles that receive the blood, at least one flow generating mechanism in communication with the test receptacles, and a clot detector configured to analyze an amount of clot formation that occurs within the blood in each receptacle. Blood contacting surfaces of a first subset of the test receptacles are coated with a first surface substrate and blood contacting surfaces of a second subset of the test receptacles are coated with a different second surface substrate. The flow generating mechanism is configured to generate a first blood flow rate through a third subset of the test receptacles and to generate a different second blood flow rate through a fourth subset of the test receptacles.

Abstract: A 3-D (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. A filler mechanism that fills the customized matrix with one or more filler materials. The one or more filler materials retained within the customized matrix are cured or solidified to produce the object.

Abstract: Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.

Abstract: Apparatus, systems, and methods are provided for assessing clot activity in blood under various conditions in vitro. The apparatus includes a plurality of test receptacles that receive the blood, at least one flow generating mechanism in communication with the test receptacles, and a clot detector configured to analyze an amount of clot formation that occurs within the blood in each receptacle. Blood contacting surfaces of a first subset of the test receptacles are coated with a first surface substrate and blood contacting surfaces of a second subset of the test receptacles are coated with a different second surface substrate. The flow generating mechanism is configured to generate a first blood flow rate through a third subset of the test receptacles and to generate a different second blood flow rate through a fourth subset of the test receptacles.

Abstract: A drug delivering medical system intended for placement into a blood vessel is provided. The drug delivering medical system includes a stent device having a plurality of interconnected distinct strut elements comprising distinct strut element surfaces. At least some of the distinct strut surfaces are neither in contact with the lumen wall nor in contact with wall-contacting flow recirculation zones. The stent device releases at least one biologically active compound intended for distal delivery and provides sufficient surface area for delivering the required drug dose to a distal tissue.

Abstract: A stent alignment system includes an implantable stent and catheter that allows the ability to precisely control translational and rotational position in a vessel of the implantable stent and catheter.

Abstract: Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.

Abstract: A flow system device used for testing/creating fluid flow. The system comprises at least one fluid filled loop and a rotor stage for maintaining at least one rotor. The loop is positioned on the rotor. The device also includes a driving motor for rotating the rotor stage and a motion controller for controlling the speed and directional motion of the motor.

Abstract: A flow system device used for testing/creating fluid flow. The system comprises at least one fluid filled loop and a rotor stage for maintaining at least one rotor. The loop is positioned on the rotor. The device also includes a driving motor for rotating the rotor stage and a motion controller for controlling the speed and directional motion of the motor.

Abstract: A stent device for minimizing deployment related injuries. The stent device includes at least one structural block of a desired length and includes a plurality of projection struts. The projection struts each have a defined shape, and form a foldable pattern so that the stent device folds onto itself. An expansion mechanism is stored within the structural block. The expansion mechanism unfolds the foldable patterns of the projection struts using expansion so that minimal damage occurs to a vessel wall.

Abstract: A flow system device used for testing/creating fluid flow. The system comprises at least one fluid filled loop and a rotor stage for maintaining at least one rotor. The loop is positioned on the rotor. The device also includes a driving motor for rotating the rotor stage and a motion controller for controlling the speed and directional motion of the motor.

Abstract: A device for triggering the inspiratory phase of a ventilator having a three-way connector with an inspiratory conduit and an expiratory conduit, each communicating with the ventilator and with a patient communicating conduit. A valve arrangement associated with both the expiratory and inspiratory conduits are automatically operated by a patient attempting to breathe, such that the patient is only exposed to the air volume in the three-way connector and not to the greater air volume of the ventilator and its connected tubing.

Abstract: A high-frequency miniature pressure ventilator system including a variable volume pressure chamber arranged to surround a portion of the thoracic cavity of a body so as to isolate the portion of the body from atmospheric pressure. A pump assembly is operable for varying the pressure within the chamber so as to apply negative external pressure to the portion of the body during a negative cycle of operation. A valve assembly is operable for opening the chamber to a predetermined pressure during a positive cycle of operation in order to normalize a base pressure from which the pressure within said chamber is varied. In another embodiment there is provided a high-frequency pressure ventilator system including a variable volume pressure chamber arranged to surround the head of a body so as to isolate the head from atmospheric pressure. A pump assembly is operable for varying the pressure within the chamber so as to apply positive external pressure to the head during a positive cycle of operation.