Patents by Inventor Kumaravel KANDASAMY

Kumaravel KANDASAMY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of droxidopa and its intermediate
    Patent number: 11192848
    Abstract: The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3 4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as described herein) from the crude compound (I), and (b) recycling and re-use it for the preparation of droxidopa. Accordingly, the present invention relates to an improved economical process for the preparation of L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine (I) or its pharmaceutically acceptable salts; wherein the process relates to recovery and recycling of the by-product compound (V) and also to re-use it for the preparation of droxidopa.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: December 7, 2021
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Milind Gharpure, Ashutosh Jagtap, Changdev Raut, Navnath Patil, Prashant Ladkat, Jaisankar Krishnapillai, Nirmal Kumar Manoharan, Kumaravel Kandasamy
  • AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE
    Publication number: 20200354308
    Abstract: The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as described herein) from the crude compound (I), and (b) recycling and re-use it for the preparation of droxidopa. Accordingly, the present invention relates to an improved economical process for the preparation of L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine (I) or its pharmaceutically acceptable salts; wherein the process relates to recovery and recycling of the by-product compound (V) and also to re-use it for the preparation of droxidopa.
    Type: Application
    Filed: January 3, 2019
    Publication date: November 12, 2020
    Applicant: PIRAMAL ENTERPRISES LIMITED
    Inventors: Milind GHARPURE, Ashutosh JAGTAP, Changdev RAUT, Navnath PATIL, Prashant LADKAT, Jaisankar KRISHNAPILLAI, Nirmal Kumar MANOHARAN, Kumaravel KANDASAMY