Patents by Inventor Kumaresh Soppimath

Kumaresh Soppimath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-ACETYLCYSTEINE COMPOSITIONS AND METHODS
    Publication number: 20220331239
    Abstract: Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.
    Type: Application
    Filed: July 5, 2022
    Publication date: October 20, 2022
    Inventors: Ronald DOMALAON, Jinjiang LI, Tushar HINGORANI, Kumaresh SOPPIMATH
  • Atropine pharmaceutical compositions
    Patent number: 11464769
    Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: October 11, 2022
    Assignee: VYLUMA INC.
    Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev
  • Vancomycin Liposome Compositions and Methods
    Publication number: 20220296515
    Abstract: The inventive subject matter is directed to compositions and methods for liposomal vancomycin that have improved pharmacokinetics and enhanced drug loading and solution stability.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 22, 2022
    Applicant: Nevakar Injectables Inc.
    Inventors: Karthik Yadav Janga, Tushar Hingorani, Jack Martin Lipman, Kumaresh Soppimath
  • N-acetylcysteine compositions and methods
    Patent number: 11413238
    Abstract: Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: August 16, 2022
    Assignee: ENDO VENTURES LIMITED
    Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
  • Norepinephrine compositions and methods therefor
    Patent number: 11413259
    Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: August 16, 2022
    Assignee: NEVAKAR INJECTABLES INC.
    Inventors: Tushar Hingorani, Kumaresh Soppimath
  • Low-Dose Carbachol Compositions And Methods For Treatment Of Night Vision Disturbance
    Publication number: 20220160674
    Abstract: Ophthalmic formulations for acute and transient treatment of night vision disturbance syndrome (NVD) are presented. Preferred formulations comprise carbachol at very low concentrations that were demonstrated to unexpectedly provide an acute and transient therapeutic effect for a desirable magnitude and period of time.
    Type: Application
    Filed: February 3, 2022
    Publication date: May 26, 2022
    Applicant: Vyluma Inc.
    Inventors: Jack Martin Lipman, Tushar Hingorani, Kumaresh Soppimath
  • EPINEPHRINE COMPOSITIONS AND CONTAINERS
    Publication number: 20220110891
    Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.
    Type: Application
    Filed: November 15, 2021
    Publication date: April 14, 2022
    Applicant: Nevakar Injectables Inc.
    Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
  • Low-dose carbachol compositions and methods for treatment of night vision disturbance
    Patent number: 11273141
    Abstract: Ophthalmic formulations for acute and transient treatment of night vision disturbance syndrome (NVD) are presented. Preferred formulations comprise carbachol at very low concentrations that were demonstrated to unexpectedly provide an acute and transient therapeutic effect for a desirable magnitude and period of time.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: March 15, 2022
    Assignee: VYLUMA INC.
    Inventors: Jack Martin Lipman, Tushar Hingorani, Kumaresh Soppimath
  • Epinephrine compositions and containers
    Patent number: 11207280
    Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: December 28, 2021
    Assignee: Nevakar Injectables Inc.
    Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
  • Low-Dose Carbachol Compositions And Methods For Treatment Of Night Vision Disturbance
    Publication number: 20210353584
    Abstract: Ophthalmic formulations for acute and transient treatment of night vision disturbance syndrome (NVD) are presented. Preferred formulations comprise carbachol at very low concentrations that were demonstrated to unexpectedly provide an acute and transient therapeutic effect for a desirable magnitude and period of time.
    Type: Application
    Filed: May 18, 2021
    Publication date: November 18, 2021
    Applicant: VYLUMA INC.
    Inventors: Jack Martin Lipman, Tushar Hingorani, Kumaresh Soppimath
  • Isoproterenol Compositions and Methods
    Publication number: 20210259994
    Abstract: Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics. In preferred aspects, formulations are terminally sterilized and packaged in a suitable format, such as a polymeric bag with metalized overwrap and include a non-contact oxygen scavenger.
    Type: Application
    Filed: February 18, 2021
    Publication date: August 26, 2021
    Applicant: Nevakar Inc.
    Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
  • N-Acetylcysteine Compositions and Methods
    Publication number: 20210251889
    Abstract: Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.
    Type: Application
    Filed: February 17, 2021
    Publication date: August 19, 2021
    Applicant: Nevakar Inc.
    Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
  • Epinephrine compositions and containers
    Patent number: 11083698
    Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: August 10, 2021
    Assignee: NEVAKAR INC.
    Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
  • Phenylephrine Hydrochloride Compositions and Containers
    Publication number: 20210228507
    Abstract: A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.
    Type: Application
    Filed: January 21, 2021
    Publication date: July 29, 2021
    Applicant: Nevakar Inc.
    Inventors: Reema Ajitkumar Puri, Harshil H. Jain, Tushar Hingorani, Kumaresh Soppimath
  • Ephedrine Compositions and Methods
    Publication number: 20210228506
    Abstract: Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.
    Type: Application
    Filed: November 12, 2020
    Publication date: July 29, 2021
    Applicant: Nevakar Inc.
    Inventors: Irfan Ali Mohammed, Tushar Hingorani, Kumaresh Soppimath
  • Atropine pharmaceutical compositions
    Patent number: 11071732
    Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: July 27, 2021
    Assignee: NEVAKAR INC.
    Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev
  • Epinephrine compositions and containers
    Patent number: 11071719
    Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: July 27, 2021
    Assignee: NEVAKAR INC.
    Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
  • Concentrated Fulvestrant Compositions
    Publication number: 20210169897
    Abstract: Compositions and methods for injectable and liquid fulvestrant formulations that have fulvestrant at a relatively high concentration stably solubilized before and after injection of the patient are provided.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 10, 2021
    Inventors: Vivek Yadav, Sriramya Garapati, Bronislava Zektser, Varun Khurana, Iouri V Ilitchev, Prem Sagar Akasapu, Tushar Hingorani, Kumaresh Soppimath, Navneet Puri
  • Atropine Pharmaceutical Compositions
    Publication number: 20210128546
    Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Nevakar Inc.
    Inventors: Kumaresh Soppimath, Tushar Hingorani
  • FORMULATION FOR USE IN A METHOD OF TREATMENT OF PAIN
    Publication number: 20210128507
    Abstract: Formulations, methods of manufacturing, methods of stabilizing, kits, and uses as medicament are provided, for example for the treatment of pain. The formulations can comprise gabapentin optionally combined with at least one non-opioid pain drug in an aqueous carrier. The pharmaceutical formulation can have a pH of about 2.0 to about 10.0. The at least one non-opioid pain drug can be acetaminophen. The components can be included in any amount suitable for purposes of obtaining properties desirable for an injectable infusion, for example an intravenous infusion.
    Type: Application
    Filed: November 16, 2020
    Publication date: May 6, 2021
    Inventors: Varun Khurana, Vivek Yadav, Jack Martin Lipman, Tao Zhang, Iouri V. Ilitchev, Tushar Hingorani, Kumaresh Soppimath, Navneet Puri