Patents by Inventor Kumarpal A. Shah

Kumarpal A. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160317573
    Abstract: A method for treating a subject suffering from age related illnesses such as Type 2 diabetes by administering to the subject a compound to down regulate Factor D or Factor H thereby providing prophylaxis and therapy to inhibit age related illnesses. The compound is a functionalized Nano Polymer of less than 100 nm, which primarily inhibits Factor D, Factor H, or both.
    Type: Application
    Filed: April 29, 2015
    Publication date: November 3, 2016
    Inventor: Kumarpal A. Shah
  • Publication number: 20160058787
    Abstract: A therapeutic model for the expedient treatment of deadly pathogens involved in pandemics and bioterrorism related events. The immune pathogenesis of deadly pathogens is redefined in the light of Recent advances in the Fundamentals of Immunology by developing three dimensional understandings of deadly pathogens and its interactions with host and its immune system. The immune pathogenesis of deadly pathogens can be treated expediently and globally with NSPS to mitigate the threat of bioterrorism and pandemics. According to a method for treating deadly pathogens having an immune regulatory molecule, the first step is providing a nano-engineered formulation of sodium polystyrene sulfonate (NSPS) having particle size less than 100 nm. A pharmaceutically effective dose of the NSPS is administered to a patient infected with the pathogen. The immune regulatory molecule is targeted with the NSPS for inhibiting serine protease activation.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 3, 2016
    Inventor: Kumarpal A. Shah
  • Publication number: 20160050856
    Abstract: Implementations provide an expandable vertical garden system comprising a frame; drip irrigation pipe(s); drainage pipe(s); a drain tray; and optionally pots or plant containers. The frame of the expandable vertical garden may comprise: holes for inserting screws which get drilled into the support wall/framework; cavities wherein pots can be snapped in and snapped out; a support element in each cavity for the pots to get good anchorage; small holes above each cavity, wherein clips to hold a horizontal irrigation pipe can be fixed in; a large hole at the bottom of the frame for inserting the drain tray; a cavity on a rear side of each frame wherein the drainage pipe can be fixed.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 25, 2016
    Inventor: Kumarpal SHAH
  • Publication number: 20140341996
    Abstract: Nanoengineering of inert polymers to develop functionalized sulfonated polymers to harness the power of Alternate complement system to stimulate and amplify cytotoxic potentials of classical and lectin based complement system Manufacturing functionalized sulfonated polymer to better penetrate tumor microenvironment, actively target various cancer antigens in conjunction with monoclonal antibodies in a safe way to inhibit host inflammatory reactions while maximizing cytotoxic potentials. The methods provide nanopolymers to safely maximize the cytotoxic potential of existing and evolving cancer therapies. Combining nanopolymers with existing and evolving cancer drugs to provide personalized cancer therapies.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 20, 2014
    Inventor: Kumarpal A. Shah
  • Patent number: 6805857
    Abstract: Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that can be readily available and deployed in real time. Polystyrene sulfonate is the answer. It is life saving and will help in the development of next generation superior vaccines.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: October 19, 2004
    Inventor: Kumarpal A. Shah
  • Publication number: 20040180055
    Abstract: Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that can be readily available and deployed in real time. Polystyrene sulfonate is the answer. It is life saving and will help in the development of next generation superior vaccines.
    Type: Application
    Filed: December 7, 2001
    Publication date: September 16, 2004
    Inventor: Kumarpal A. Shah
  • Publication number: 20030203031
    Abstract: Polystyrene sulfonate (PSS) is a known immune-modulation drug for complement inhibition. Our due diligent review of this drug identifies it as a broad-spectrum immune modulation drug that therapeutically impacts innate and adaptive immune functions. The drug is first of a class of drug that modulates immune responses in accordance to recent advances of immunology. The therapeutic applications with relation to HIV are detailed.
    Type: Application
    Filed: May 7, 2003
    Publication date: October 30, 2003
    Inventor: Kumarpal A. Shah
  • Publication number: 20020106346
    Abstract: Polystyrene sulfonate (PSS) is a known immune-modulation drug for complement inhibition. Our due diligent review of this drug identifies it as a broad-spectrum immune modulation drug that therapeutically impacts innate and adaptive immune functions. The drug is first of a class of drug that modulates immune responses in accordance to recent advances of immunology. The therapeutic applications with relation to HIV are detailed.
    Type: Application
    Filed: September 19, 2001
    Publication date: August 8, 2002
    Inventor: Kumarpal A. Shah
  • Patent number: 5976780
    Abstract: A macroencapsulation device for somatic cells using ultrapurified Na alginate and polysulfone hollow fibers of 30 kDa molecular weight cutoff. Ultrapurified Na alginate material is used which has a high `G` content, low endotoxin content, low divalent metal toxins and low protein impurities. Islet cells prior to being encapsulated, are irrigated with Hank's modified solution (without Ca and Mg) containing gentamycin, vancomycin and amphotericin B and then passed through a leukoabsorb filter to reduce the donor antigen load of passenger leukocytes and to reduce the bioburden of microorganisms including viruses. Encapsulation is done in RPMI 1640 tissue culture fluid containing necessary nutritional supplements and ATP source of energy. The open ends of the fiber are covered with a porous membrane. To further improve biocompatibility, the outer wall of the polysulfone is lightly gelled with alginate gel.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: November 2, 1999
    Inventor: Kumarpal A. Shah
  • Patent number: 5837444
    Abstract: An apparatus for collecting a subpopulation of cells larger than a predetermined size from a collagenase distended organ by circulating fluid through a closed loop system. The closed loop system includes a digesting chamber to liberate cells from the organ, a cell collection chamber, and a filter adjacent the cell collection chamber for retaining cells larger than the predetermined size. The circulating fluid transports liberated cells through the cell collection chamber to the filter. Subsequently, the cells on the filter are flushed back into the cell collection chamber by a density medium. A tube then withdraws the desired subpopulation of cells from the cell collection chamber.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: November 17, 1998
    Inventor: Kumarpal A. Shah