Patents by Inventor Kumiko KUMAGAYE

Kumiko KUMAGAYE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-Acting Adrenomedullin Derivatives
    Publication number: 20230120030
    Abstract: There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a compound represented by formula (I): A-Ln-B (I), wherein A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is bound to the modifying group A or the linking group L via the N-terminal amino group of the peptide moiety B, or a salt thereof, or a hydrate thereof.
    Type: Application
    Filed: July 29, 2022
    Publication date: April 20, 2023
    Applicant: University of Miyazaki
    Inventors: Kazuo Kitamura, Johji Kato, Keishi Kubo, Kenji Kuwasako, Shigeru Kubo, Kumiko Kumagaye
  • Long-acting adrenomedullin derivatives
    Patent number: 11414474
    Abstract: There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a compound represented by formula (I): A-Ln-B (I), wherein A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is bound to the modifying group A or the linking group L via the N-terminal amino group of the peptide moiety B, or a salt thereof, or a hydrate thereof.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: August 16, 2022
    Assignee: University of Miyazaki
    Inventors: Kazuo Kitamura, Johji Kato, Keishi Kubo, Kenji Kuwasako, Shigeru Kubo, Kumiko Kumagaye
  • LONG-ACTING ADRENOMEDULLIN DERIVATIVES
    Publication number: 20180170991
    Abstract: There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a compound represented by formula (I): A-Ln-B (I), wherein A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is bound to the modifying group A or the linking group L via the N-terminal ammo group of the peptide moiety B, or a salt thereof, or a hydrate thereof.
    Type: Application
    Filed: March 20, 2015
    Publication date: June 21, 2018
    Inventors: Kazuo Kitamura, Johji KATO, Keishi KUBO, Kenji KUWASAKO, Shigeru KUBO, Kumiko KUMAGAYE