Abstract: (Problem to be Solved) To obtain a hollow-fiber membrane blood purification device having excellent blood compatibility and antioxidative performance and highly stable antioxidative performance under severe environments. (Solution) A hollow-fiber membrane blood purification device provided with a hollow-fiber membrane containing a polysulfone-based resin, a polyvinyl pyrrolidone, a fat-soluble vitamin and a polymer having an ester group, in which an abundance of the fat-soluble vitamin on all surfaces of the hollow-fiber membrane is 2 mg or more and 18 mg or less based on 1 g of the hollow-fiber membrane, when the hollow-fiber membrane is extracted with ethanol, an extract is dried and subjected to measurement of an infrared absorption spectrum (IR), a ratio of absorbance (Abs(A)) of peak A in a vicinity of 1720 to 1730 cm?1 to absorbance (Abs(B)) of peak B in a vicinity of 1660 to 1670 cm?1, (Abs(A)/Abs(B)), is 0.01 or more and 0.

Abstract: Piperidine compounds of formula II: ##STR1## that exhibit anticholinesterase activity and are effective in treating dementia.

Abstract: Quinoline derivatives of the formula, ##STR1## wherein >A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior anti-acetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.

Abstract: Quinoline derivatives of the formula, ##STR1## wherein > A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior antiacetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.