Patents by Inventor Kumiko Takeuchi

Kumiko Takeuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPR119 agonists
    Patent number: 8207344
    Abstract: GPR119 agonist compounds of the formula: and pharmaceutical compositions for the treatment of diabetes and obesity.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: June 26, 2012
    Assignee: Eli Lilly and Company
    Inventors: David Gene Barrett, Ana Belen Bueno Melendo, Jeffry Bernard Franciskovich, Bin Liu, Kumiko Takeuchi
  • 6-substituted nicotinamide derivatives as opioid receptor antagonists
    Patent number: 8101638
    Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diasteromers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: January 24, 2012
    Assignee: Eli Lilly and Company
    Inventors: Miles Goodman Siegel, Russell Dean Stucky, Kumiko Takeuchi
  • Substituted carboxamides
    Patent number: 7960419
    Abstract: This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: June 14, 2011
    Assignee: Eli Lilly and Company
    Inventors: Ryan Thomas Backer, Matthew Joseph Fisher, Sean Patrick Hollinshead, Steven Lee Kuklish, Edward C R Smith, Kumiko Takeuchi
  • GPR119 Agonists
    Publication number: 20110015199
    Abstract: GPR119 agonist compounds of the formula: and pharmaceutical compositions for the treatment of diabetes and obesity.
    Type: Application
    Filed: July 12, 2010
    Publication date: January 20, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: David Gene Barrett, Ana Belen Bueno Melendo, Jeffry Bernard Franciskovich, Bin Liu, Kumiko Takeuchi
  • SUBSTITUTED CARBOXAMIDES
    Publication number: 20090182025
    Abstract: This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
    Type: Application
    Filed: June 7, 2007
    Publication date: July 16, 2009
    Inventors: Ryan Thomas Backer, Matthew Joseph Fisher, Sean Patrick Hollinshead, Steven Lee Kuklish, Edward C.R. Smith, Kumiko Takeuchi
  • 6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20090023785
    Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diasteromers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 22, 2009
    Inventors: Concepcion Pedregal-Tercero, Miles Goodman Siegel, Russell Dean Stucky, Kumiko Takeuchi
  • DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20080269296
    Abstract: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3?, E, v, y, z. A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
    Type: Application
    Filed: March 21, 2008
    Publication date: October 30, 2008
    Inventors: Maria-Jesus Blanco-Pillado, Mark Donald Chappell, Marta Garcia De La Torre, Nuria Diaz Buezo, James Erwin Fritz, William Glen Holloway, James Edward Matt, Charles Howard Mitch, Concepcion Pedregal-Tercero, Steven James Quimby, Miles Goodman Siegel, Dana Rae Smith, Russell Dean Stucky, Kumiko Takeuchi, Elizabeth Marie Thomas, Chad Nolan Wolfe
  • DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20080255152
    Abstract: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3?, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
    Type: Application
    Filed: March 21, 2008
    Publication date: October 16, 2008
    Inventors: Maria-Jesus Blanco-Pillado, Mark Donald Chappell, Marta Garcia De La Torre, Nuria Diaz Buezo, James Erwin Fritz, William Glen Holloway, James Edward Matt, Charies Howard Mitch, Concepcion Pedregal-Tercero, Steven James Quimby, Miles Goodman Siegel, Dana Rae Smith, Russell Dean Stucky, Kumiko Takeuchi, Elizabeth Marie Thomas, Chad Nolan Wolfe
  • 6-substituted nicotinamide derivatives as opioid receptor antagonists
    Patent number: 7399774
    Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: July 15, 2008
    Assignee: Eli Lilly and Company
    Inventors: Miles Goodman Siegel, Russell Dean Stucky, Kumiko Takeuchi
  • Opioid receptor antagonists
    Patent number: 7396943
    Abstract: A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: July 8, 2008
    Assignee: Eli Lilly and Company
    Inventors: Dana Rae Benesh, Maria Jesus Blanco-Pillado, Charles Howard Mitch, Kumiko Takeuchi
  • Diaryl ethers as opioid receptor antagonist
    Patent number: 7381719
    Abstract: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3?, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: June 3, 2008
    Assignee: Eli Lilly and Company
    Inventors: Maria-Jesus Blanco-Pillado, Marta Garcia De La Torre, Nuria Diaz Buezo, William Glen Holloway, James Edward Matt, Charles Howard Mitch, Concepcion Pedregal-Tercero, Dana Rae Smith, Russell Dean Stucky, Kumiko Takeuchi
  • Indole derivatives for the treatment of depression and anxiety
    Patent number: 7144898
    Abstract: The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: December 5, 2006
    Assignee: Eli Lilly and Company
    Inventors: Marvin Martin Hansen, John Xiaoqiang He, Nicholas Allan Honigschmidt, Daniel James Koch, Todd Jonathan Kohn, Vincent Patrick Rocco, Patrick Gianpietro Spinazze, Kumiko Takeuchi
  • Diaryl ethers as opioid receptor antagonist
    Publication number: 20060217372
    Abstract: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3?, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
    Type: Application
    Filed: September 17, 2003
    Publication date: September 28, 2006
    Inventors: Maria-Jesus Blanco-Pillado, Mark Chappell, Marta De La Torre, Nuria Diaz Buezo, James Fritz, William Holloway, James Matt, Charles Mitch, Concepcion Pedregal-Tercero, Steven Wuimby, Miles Siegel, Dana Smith, Russell Stucky, Kumiko Takeuchi, Elizabeth Thomas, Chad Wolfe
  • 6-Substituted nicotinamide derivatives as opioid receptor antagonists
    Publication number: 20060205715
    Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
    Type: Application
    Filed: February 25, 2004
    Publication date: September 14, 2006
    Inventors: Concepcion Pedregal-Tercero, Miles Siegel, Russell Stucky, Kumiko Takeuchi
  • Opioid receptor antagonists
    Publication number: 20060166987
    Abstract: A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed.
    Type: Application
    Filed: March 1, 2004
    Publication date: July 27, 2006
    Inventors: Dana Benesh, Maria Blanco-Pillado, Charles Mitch, Kumiko Takeuchi
  • Benzofuran derivatives
    Patent number: 6844344
    Abstract: The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: January 18, 2005
    Assignee: Eli Lilly and Company
    Inventors: John Xiaoqiang He, Nicholas Allan Honigschmidt, Todd Jonathan Kohn, Vincent Patrick Rocco, Patrick Gianpietro Spinazze, Kumiko Takeuchi
  • Tropane linked benzofuran derivatives
    Patent number: 6835733
    Abstract: The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: December 28, 2004
    Assignee: Eli Lilly and Company
    Inventors: John Xiaoqiang He, Nicholas Allan Honigschmidt, Todd Jonathan Kohn, Vincent Patrick Rocco, Patrick Gianpietro Spinazze, Kumiko Takeuchi
  • Piperidines derivatives and their use as serotonin receptor antagonists
    Patent number: 6784180
    Abstract: The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: August 31, 2004
    Assignee: Eli Lilly and Company
    Inventors: John Xiaoqiang He, Nicholas Allan Honigschmidt, Todd Jonathan Kohn, Vincent Patrick Rocco, Patrick Gianpietro Spinazze, Kumiko Takeuchi
  • Pharmaceutical compounds
    Publication number: 20040030131
    Abstract: A compound of the formula in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group, said group being optionally substituted with 1 to 3 substituents selected from C1-4 alkyl, hydroxymethyl, C1-4 alkoxymethyl and amido, R3 is a naphthyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; and m is 0 or 1, provided that when m is 1 then n is 1; or a salt or ester thereof.
    Type: Application
    Filed: September 3, 2003
    Publication date: February 12, 2004
    Inventors: Martine Keenan, Vincent Patrick Rocco, Kumiko Takeuchi, David Edward Tupper, Vincent Vivien
  • Hypoglycemic imidazoline compounds
    Publication number: 20040009976
    Abstract: This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical compositions comprising them, and to processes for their preparation.
    Type: Application
    Filed: April 30, 2002
    Publication date: January 15, 2004
    Inventors: Kumiko Takeuchi, Michael Robert Jirousek, Michael Paal, Gerd Ruhter, Theo Schotten