Patents by Inventor Kumkum Saxena

Kumkum Saxena has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C3 FUSION PROTEIN AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20220265765
    Abstract: The present invention provides, among other things, improved therapeutic compositions comprising a C3 fusion protein and methods of making and using the same. In particular, the present invention provides improved methods for the treatment of spinal cord injury and other CNS trauma and/or facilitate axon growth or other tissue repair.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: Ricardo BORJAS, Mark FLEMING, Mei HUANG, Mayur JAIN, Tapan SANGHVI, Kumkum SAXENA, Amaris TORRES-DELGADO, Ping YIN, Lisa MCKERRACHER, Elizabeth RYU
  • C3 fusion protein and methods of making and using thereof
    Patent number: 11324802
    Abstract: The present invention provides, among other things, improved therapeutic compositions comprising a C3 fusion protein and methods of making and using the same. In particular, the present invention provides improved methods for the treatment of spinal cord injury and other CNS trauma and/or facilitate axon growth or other tissue repair.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 10, 2022
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Ricardo Borjas, Mark Fleming, Mei Huang, Mayur Jain, Tapan Sanghvi, Kumkum Saxena, Amaris Torres-Delgado, Ping Yin, Lisa McKerracher, Elizabeth Ryu
  • C3 FUSION PROTEIN AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20210138035
    Abstract: The present invention provides, among other things, improved therapeutic compositions comprising a C3 fusion protein and methods of making and using the same. In particular, the present invention provides improved methods for the treatment of spinal cord injury and other CNS trauma and/or facilitate axon growth or other tissue repair.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 13, 2021
    Inventors: Ricardo BORJAS, Mark FLEMING, Mei HUANG, Mayur JAIN, Tapan SANGHVI, Kumkum SAXENA, Amaris TORRES-DELGADO, Ping YIN, Lisa MCKERRACHER, Elizabeth RYU
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 8712749
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • CRYSTAL STRUCTURE OF HUMAN JAK3 KINASE DOMAIN COMPLEX AND BINDING POCKETS THEREOF
    Publication number: 20130137125
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.
    Type: Application
    Filed: May 24, 2012
    Publication date: May 30, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 8192972
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: June 5, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • CRYSTAL STRUCTURE OF HUMAN JAK3 KINASE DOMAIN COMPLEX AND BINDING POCKETS THEREOF
    Publication number: 20110014680
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Application
    Filed: May 26, 2009
    Publication date: January 20, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: HARMON ZUCCOLA, MARC JACOBS, LOVORKA SWENSON, KUMKUM SAXENA
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 7558717
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: July 7, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Crystal structure of FMS-like tyrosine kinase
    Patent number: 7494795
    Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: February 24, 2009
    Inventors: James Paul Griffith, James Roger Black, Carlos H. Faerman, Lovorka Lora Swenson, Michael Andrew Wynn, Fan Lu, Judith A. Lippke, Kumkum Saxena
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Publication number: 20060030018
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Application
    Filed: April 26, 2005
    Publication date: February 9, 2006
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Crystal structure of FMS-like tyrosine kinase
    Publication number: 20050181975
    Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.
    Type: Application
    Filed: September 15, 2004
    Publication date: August 18, 2005
    Inventors: James Griffith, James Black, Carlos Faerman, Lovorka Swenson, Michael Wynn, Fan Lu, Judith Lippke, Kumkum Saxena