Abstract: Pump assemblies and systems are provided. For example, a pump assembly comprises a pump head, a bezel surrounding an outer perimeter of the pump head, a motor, and tubing. The bezel comprises a bezel upper side, a bezel lower side opposite the bezel upper side, a bezel inlet side extending from the bezel upper side to the bezel lower side, and a bezel outlet side opposite the bezel inlet side and extending from the bezel upper side to the bezel lower side. The bezel defines an inlet channel on the bezel inlet side and an outlet channel on the bezel outlet side, each of the inlet channel and the outlet channel guiding the tubing into the pump head. An exemplary pump system comprises a plurality of pump assemblies that each supply a fluid to a cooling circuit and a base for supporting the plurality of pump assemblies.

Abstract: Pump heads for peristaltic pump assemblies are provided. For example, a pump head for a peristaltic pump comprises an occlusion bed, a rotor guide, a rotor assembly positioned between the occlusion bed and the rotor guide, and a pathway for tubing. The pathway comprises an inlet portion, an outlet portion, and a connecting portion that connects the inlet and outlet portions. The inlet portion is defined between the occlusion bed and the rotor guide, the outlet portion is defined between the occlusion bed and the rotor guide, and the connecting portion is defined between the occlusion bed and the rotor assembly. Further, the occlusion bed is movable with respect to the rotor guide and the rotor assembly. In exemplary embodiments, the pump head urges fluid flow through the tubing to supply a cooling fluid to a medical probe assembly for delivering energy to a patient's body.

Abstract: A pump system for pumping a coolant fluid for cooled radiofrequency ablation treatment includes a housing having a front, a back, a right side, a left side, a top surface, and a bottom surface, and a plurality of peristaltic pump assemblies. The top surface of the housing includes a central channel between at least two of the peristaltic pump assemblies configured to drain fluid away from the front of the housing. A cooled radiofrequency ablation system additionally includes a pump system and a generator having mating surfaces such that the pump system can sit stably on top of the generator.

Abstract: Indicators for indicating the integrity of a seal of a sterilization container are provided. For example, a seal indicator may indicate whether the container is sufficiently sealed to prevent an ingress of contaminants into the container. If the container is sufficiently sealed, the seal indicator is in one state and displays a first indicium, and if the sterilization container is not sufficiently sealed, the seal indicator is in another state and displays a second indicium. Thus, the seal indicator undergoes a visible change in state when the sterilization container transitions from unsealed to sealed, such that the user may be assured that the container is properly sealed to maintain sterility of the articles post-sterilization. Further, the seal indicator undergoes a visible change in state if the seal is subsequently broken, to signal to the user that the seal and the sterility of the container interior has been compromised.

Abstract: A head cover that can be worn by health care professionals is provided. The head cover includes a surgical cap portion and a bouffant cap portion. The surgical cap portion includes a top surface and a side panel secured to the top surface via a seam. Further, the bouffant cap portion is secured to a rear portion of the side panel, where the bouffant cap portion is maintained against the rear portion of the side panel in an undeployed state and is deployable from the rear portion of the side panel to contain a wearer's hair. As such, the head cover enables a wearer to secure his or her hair inside the bouffant cap as needed, yet bouffant cap portion does not cover the wearer's entire head, which minimizes the amount of heat that is trapped within the head cover and increases the level of comfort for the wearer.

Abstract: The present disclosure provides sterilization containers with features for sealing a volume against an ingress of contaminants. The present disclosure also provides a sterility breach detection system for detecting whether the sterilization container seal has been breached, which potentially could compromise the sterility of any contents of the container. Further, the present disclosure provides a controller system for detecting, tracking, and alerting a user to the state of a sterilization container, such as whether the container seal has been breached. The sterility breach detection system and/or the controller system may utilize a smart gasket to detect breaches in a seal of a sterilization container, and a controller in operative communication with the smart gasket may activate an indicator to alert a user to a detected breach in the seal.

Abstract: Sterilization packaging systems with features for sealing a volume against an ingress of contaminants are provided. Such features include a sealing assembly including a gasket and a sheet of filter material. The sealing assembly seals a lid to a seal rim of a base. The gasket has an upper surface, outer edge, and inner edge. The upper surface of the gasket comprises a first row of alternating protrusions and indentations and a second row of alternating protrusions and indentations that define a channel therebetween. The sheet of filter material extends from an inner edge of the gasket. The gasket completely surrounds the sheet of filter material, wherein the indentations and channel facilitate delivery of a sterilization agent through the filter material. A sterilization assembly including a lid having a plurality of protrusions in its upper surface in conjunction with a gasket having a smooth upper surface is also provided.

Abstract: Provided is a pharmaceutical composition including an effective amount of mesenchymal stem cell derived exosomes. Also provided is a use of the pharmaceutical composition for preserving cartilage tissue, promoting cartilage regeneration and repairing damaged joints, thereby preventing or treating joint disorders in a subject in need thereof.

Abstract: Sterilization packaging systems with features for sealing a volume against an ingress of contaminants are provided. Such features include a sealing assembly including a gasket and a sheet of filter material. The sealing assembly seals a lid to a seal rim of a base. The gasket has an upper surface, outer edge, and inner edge. The upper surface of the gasket comprises a first row of alternating protrusions and indentations and a second row of alternating protrusions and indentations that define a channel therebetween. The sheet of filter material extends from an inner edge of the gasket. The gasket completely surrounds the sheet of filter material, wherein the indentations and channel facilitate delivery of a sterilization agent through the filter material. A sterilization assembly including a lid having a plurality of protrusions in its upper surface in conjunction with a gasket having a smooth upper surface is also provided.

Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.

Abstract: Pump heads for peristaltic pump assemblies are provided. For example, a pump head for a peristaltic pump comprises an occlusion bed, a rotor guide, a rotor assembly positioned between the occlusion bed and the rotor guide, and a pathway for tubing. The pathway comprises an inlet portion, an outlet portion, and a connecting portion that connects the inlet and outlet portions. The inlet portion is defined between the occlusion bed and the rotor guide, the outlet portion is defined between the occlusion bed and the rotor guide, and the connecting portion is defined between the occlusion bed and the rotor assembly. Further, the occlusion bed is movable with respect to the rotor guide and the rotor assembly. In exemplary embodiments, the pump head urges fluid flow through the tubing to supply a cooling fluid to a medical probe assembly for delivering energy to a patient's body.

Abstract: A pump system for pumping a coolant fluid for cooled radiofrequency ablation treatment includes a housing having a front, a back, a right side, a left side, a top surface, and a bottom surface, and a plurality of peristaltic pump assemblies. The top surface of the housing includes a central channel between at least two of the peristaltic pump assemblies configured to drain fluid away from the front of the housing. A cooled radiofrequency ablation system additionally includes a pump system and a generator having mating surfaces such that the pump system can sit stably on top of the generator.

Abstract: Pump assemblies and systems are provided. For example, a pump assembly comprises a pump head, a bezel surrounding an outer perimeter of the pump head, a motor, and tubing. The bezel comprises a bezel upper side, a bezel lower side opposite the bezel upper side, a bezel inlet side extending from the bezel upper side to the bezel lower side, and a bezel outlet side opposite the bezel inlet side and extending from the bezel upper side to the bezel lower side. The bezel defines an inlet channel on the bezel inlet side and an outlet channel on the bezel outlet side, each of the inlet channel and the outlet channel guiding the tubing into the pump head. An exemplary pump system comprises a plurality of pump assemblies that each supply a fluid to a cooling circuit and a base for supporting the plurality of pump assemblies.

Abstract: Sterilization packaging systems with features for sealing a volume against an ingress of contaminants are provided. Such features include a sealing assembly including a gasket and a sheet of filter material. The sealing assembly seals a lid to a seal rim of a base. The gasket has an upper surface, outer edge, and inner edge. The upper surface of the gasket comprises a first row of alternating protrusions and indentations and a second row of alternating protrusions and indentations that define a channel therebetween. The sheet of filter material extends from an inner edge of the gasket. The gasket completely surrounds the sheet of filter material, wherein the indentations and channel facilitate delivery of a sterilization agent through the filter material. A sterilization assembly including a lid having a plurality of protrusions in its upper surface in conjunction with a gasket having a smooth upper surface is also provided.

Abstract: The present invention is directed to a system for delivering radiofrequency ablation energy to an area or volume of tissue. The system includes a wrap, where a stiffening element surrounds an opening in the wrap, where the stiffening element transfers radial compression to the area or volume of tissue, where the radial compression increases stability of the area or volume of tissue; and at least one radiofrequency ablation probe having an active electrode, where the at least one radiofrequency ablation probe is connected to a radiofrequency generator via a lead. A device that includes a wrap and a method of delivering radiofrequency ablation energy to a volume of tissue via the device are also described.

Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.