Abstract: The present invention provides an invasive cancer stem cell (iCSC) or a substantively homogeneous cell population including said iCSC based on a cell-surface biomarker specifically localizing to the invadopodia of said iCSC. The present invention further provides an invasive leukemia stem cell (iLSC) or a substantively homogeneous cell population including said iLSC based on a cell-surface biomarker specifically localizing to the invadopodia of said iLSC. The present invention also provides a method or a kit of determining a diagnosis of aggressive solid tumor or hematopoietic cancer.

Abstract: The present disclosure provides an isolated invasive cancer stem cell (iCSC) or a substantially homogeneous iCSC population comprising said iCSC, which is positive for the marker AMFR on the cell membrane. The present disclosure also provides a method of detecting the iCSC within an established cancer or a collection of cancer cells. The present disclosure also provides a method of isolating the iCSC or a substantially homogeneous cell population comprising said iCSC from an established cancer or a collection of cancer cells.

Abstract: An electronic microscope includes a carrier, a first driving unit, a flow-buffer unit and an electron source. The carrier carries a sample. The first driving unit drives a first fluid to flow along a first flow path, wherein the first flow path passes through the sample. The flow-buffer unit is disposed on the first flow path to perform buffering on the first fluid, wherein the first fluid flows through the flow-buffer unit and the carrier in sequence. The electron source provides an electron beam to the sample.

Abstract: An electronic microscope includes a carrier, a first driving unit, a flow-buffer unit and an electron source. The carrier carries a sample. The first driving unit drives a first fluid to flow along a first flow path, wherein the first flow path passes through the sample. The flow-buffer unit is disposed on the first flow path to perform buffering on the first fluid, wherein the first fluid flows through the flow-buffer unit and the carrier in sequence. The electron source provides an electron beam to the sample.

Abstract: A liquid transporting device using electrowetting on dielectric technique is provided. A sampling liquid is accurately transported on a substrate in a channel-free manner. The sampling liquid is spun off the substrate by a centrifugal force after the sampling liquid has been detected. The liquid transporting device can be applied to a biochemical detecting apparatus and a biochemical detecting method, thereby fulfilling requirements of accurate sample transportation in the biomedical field. The liquid transporting device is simplified to reduce overall costs, thus being helpful for decreasing high prices of biomedical detecting systems.

Abstract: A micro-fluidic oscillator comprises a main body and a cover body for covering the main body. An oscillation chamber is disposed on the main body to provide an oscillation space for fluid. A sudden-expansion micro-nozzle is connected with one end of the oscillation chamber, and an outlet passage is connected with the other end of the oscillation chamber. Two fluid-separating bodies are located at the connection positions of the outlet passage and the oscillation chamber, respectively. Two feedback channels are located outside two attachment walls. The sudden-expansion micro-nozzle is used to break the viscous shear stress between fluid and the walls and to generate unstable flow and oscillation. Moreover, the two feedback channels have different lengths, inside diameters and alternate outlet positions to further enhance the oscillation of fluid.

Abstract: A micro-fluidic oscillator comprises a main body and a cover body for covering the main body. An oscillation chamber is disposed on the main body to provide an oscillation space for fluid. A sudden-expansion micro-nozzle is connected with one end of the oscillation chamber, and an outlet passage is connected with the other end of the oscillation chamber. Two fluid-separating bodies are located at the connection positions of the outlet passage and the oscillation chamber, respectively. Two feedback channels are located outside two attachment walls. The sudden-expansion micro-nozzle is used to break the viscous shear stress between fluid and the walls and to generate unstable flow and oscillation. Moreover, the two feedback channels have different lengths, inside diameters and alternate outlet positions to further enhance the oscillation of fluid.