Abstract: The present invention relates to a pyrrolobenzodiazepine derivative compound, a conjugate of the same with a ligand, and the use of the same. The pyrrolobenzodiazepine derivative compound is more stable in plasma, is stable even in circulation, and exhibits excellent efficacy. In particular, the conjugate of the pyrrolobenzodiazepine derivative compound with a ligand has a great advantage in that it is possible to target and specifically treat proliferative disease such as cancer, maximize drug efficacy, and minimize the expression of side effects since the conjugate more stably reaches the target cell and effectively exerts drug efficacy while toxicity is greatly reduced as a linker technology that allows drugs to be easily released within cancer cells and maximize drug efficacy is incorporated.

Abstract: The invention discloses a dual-modes switching method for blocking a network connection, comprising: a data packet collecting step of collecting data packets transmitting from all network nodes in a network segment, a data packet analyzing step of analyzing the data packets collected to obtain network node identification data, a list comparing step of comparing the network node identification data with identification data registered in an information device list to determine an illegal network node, an illegal-network-node-type determining step of determining what kind of type the illegal network node is, and a network connection blocking step of switching a first network connection blocking mode and a second network connection blocking mode according to the type of the illegal network node, thereby blocking the network connection of the illegal network.

Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.

Abstract: The present invention discloses a network connection managing system comprising one or more information devices, a network node data verifying device and a network node connection managing device. The information device is a network node installed with a mobile network card such that a MAC address of the mobile network card and network node identifying data of the network node are transmitted to the network node data verification device by a data reporting software, and are then compared by the network node data verifying device. The network node connection managing device is connected to the network node data verifying device and blocks a network connection for the network node according to a comparison result.

Abstract: Disclosed is an IPv6 network node managing method, comprising: a packet collecting step, a packet analyzing step, and an IPv6 address assigning step, for assigning a network node management IPv6 address with a visually recognizable suffix address code to a target network node which requests an IPv6 address assignment of DHCPv6, thereby improving IPv6 address recognition of the target network node and facilitating management of the network nodes.

Abstract: The present invention relates to a novel pyrrolobenzodiazepine dimer compound or a pharmaceutically acceptable salt thereof, a ligand-drug conjugate compound thereof, or a composition containing the same and therapeutic use of the same as an anticancer agent. The pyrrolobenzodiazepine dimer compound according to the present invention exhibits anticancer activity equivalent to or superior to that of existing anticancer agents when being applied to a ligand-drug conjugate as a drug and administered as well as exhibits low activity and greatly diminished toxicity in the free toxin form and thus has a significantly improved therapeutic index. Hence, the pyrrolobenzodiazepine dimer compound is highly industrially applicable in that targeting of proliferative diseases such as cancer is possible, specific treatment of the proliferative diseases is possible, the drug efficacy can be maximized, and the expression of side effects can be minimized.

Abstract: The invention discloses a dual-modes switching method for blocking a network connection, comprising: a data packet collecting step of collecting data packets transmitting from all network nodes in a network segment, a data packet analyzing step of analyzing the data packets collected to obtain network node identification data, a list comparing step of comparing the network node identification data with identification data registered in an information device list to determine an illegal network node, an illegal-network-node-type determining step of determining what kind of type the illegal network node is, and a network connection blocking step of switching a first network connection blocking mode and a second network connection blocking mode according to the type of the illegal network node, thereby blocking the network connection of the illegal network.

Abstract: An information security management system comprises a data collecting unit, an integrating analyzing unit, a regulation inspecting unit and a network blocking unit for integrating information security database data of a plurality of third-party management consoles. When an endpoint device is not in conformity with information security policy, the information security management system of the present invention could block the endpoint device from network communication with the network environment to enhance the security of the endpoint device.

Abstract: Disclosed is an IPv6 network node managing method, comprising: a packet collecting step, a packet analyzing step, and an IPv6 address assigning step, for assigning a network node management IPv6 address with a visually recognizable suffix address code to a target network node which requests an IPv6 address assignment of DHCPv6, thereby improving IPv6 address recognition of the target network node and facilitating management of the network nodes.

Abstract: The present invention discloses a network connection managing system comprising one or more information devices, a network node data verifying device and a network node connection managing device. The information device is a network node installed with a mobile network card such that a MAC address of the mobile network card and network node identifying data of the network node are transmitted to the network node data verification device by a data reporting software, and are then compared by the network node data verifying device. The network node connection managing device is connected to the network node data verifying device and blocks a network connection for the network node according to a comparison result.

Abstract: A network security management system which manages an object node belonging to an intranet, including: an information collecting device, a type determining device and an event management device; the information collecting device being configured to collect domain information, computer name information and account information of each object node which is transmitted when each object node performs a login operation; the type determining device being configured to perform a comparison between the node information received by the information collection device and a node management list to determine a node type belonging to each object node; the event management device being configured to decide whether the object node has an operating privilege, or to give to the object node the operating privilege corresponding to the node type of the object node based on the compared result from the type determining device.

Abstract: A network security management system which manages an object node belonging to an intranet, including: an information collecting device, a type determining device and an event management device; the information collecting device being configured to collect domain information, computer name information and account information of each object node which is transmitted when each object node performs a login operation; the type determining device being configured to perform a comparison between the node information received by the information collection device and a node management list to determine a node type belonging to each object node; the event management device being configured to decide whether the object node has an operating privilege, or to give to the object node the operating privilege corresponding to the node type of the object node based on the compared result from the type determining device.

Abstract: The invention provides a method for distinguishing and blocking off a network node. The method includes a packet receiving step and a packet distinguishing processing step. The packet receiving step is provided for receiving an ARP packet from a network node within a network segment. The packet distinguishing processing step is provided for distinguishing whether the network node is authorized or not by having an internet protocol address and a media access control address of the ARP packet to be compared with a permission list, and then for permitting the network node to connect with the network segment or for blocking off the network node. Thereby the network system can be protected and the safety of the network in use increases.

Abstract: A presser foot that is adapted to extend forwardly upon attachment to a presser bar of a sewing machine that sews a fabric pressed under the presser foot includes a presser foot element that is pivotably attached to the presser bar and is biased pivotally with respect thereto by a spring, the element having a vertical slot with an open forward end and a rear end that is closed at a vertical needle-accommodating through aperture located ahead of a pivotal axis about which the presser foot pivots about the presser bar. The presser foot is formed with two recesses, one on each side of the forwardly open slot, each recess being longitudinally defined by outwardly extending flanges at each end, and a first pair of rolling elements that are rotatably supported coaxially by the presser foot element, one inside each of the two recesses about a common first axis that is disposed beneath the needle accommodating aperture, so that the rolling elements press on a fabric being sewn thereunder by the needle.