Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: The present invention relates to compositions and methods for the detecting, preventing, treating, and empirically investigating seizures and seizure related disorders (e.g., West syndrome, TSC, childhood absence epilepsy, benign focal epilepsies of childhood, juvenile myoclonic epilepsy (JME), temperol lobe epilepsy, frontal lobe epilepsy, Lennox-Gastaut syndrome, occipital lobe epilepsy). In particular, the present invention provides compositions and methods for detecting, treating, preventing and empirical investigating seizures and seizure related disorders through inhibition of mTOR function. In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents (e.g., rapamycin) in the detecting, preventing, treating, and empirical investigating of seizures and seizure related disorders.

Abstract: A high-performance negative ion generating module includes a high-voltage electric field catalyzer unit formed of multiple catalyzer reaction boards and two high-voltage discharging panels for discharging a high voltage to produce a high voltage electric field, and an ion generator kit formed of a first ion generating panel, which has activation tubes respectively coated with VO2 and TiO2, and a metal coating and electrically connected to the negative pole of the power supply, and a second ion generating panel, which has discharging terminals electrically connected to the positive pole of the power supply and respectively aimed at the activation tubes for causing an electron wind to flow through the activation tubes to enhance air cleaning.

Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

Abstract: A power-saving lamp is constructed to include a lamp head, a bulb fastened to the lamp head, a polygonal light emitting circuit assembly suspended from a bracket in the lamp head within the bulb, the polygonal light emitting circuit assembly having LEDs in each of the peripheral sidewalls thereof, and a power control circuit board mounted in the lamp head and electrically connected between the lamp head and the polygonal light emitting circuit assembly to convert input AC power from the lamp head into the desired working voltage for the polygonal light emitting circuit assembly.

Abstract: Methods for treating proliferative disorders, using GDP-bound Ras proteins, wild-type or mutant, such as RasN17N69, and A15N69 are described. Pharmaceutical compositions and kits for treatment of mammals, such as humans, with Ras-mediated proliferative disorders are also described.

Abstract: Disclosed is an improved window sash latch for use in a pivotal window sash adapted for installation in a master frame of a double-hung sash window assembly. The latch has a housing having a top wall having an access opening therethrough, a pair of opposing side walls and a single end wall extending between the side walls. Each of said side walls and the end wall extend from said top wall and have a free end opposite the top wall. There is a latch bolt slidably received in the housing and having a top wall, two opposing side walls and two opposing end walls. Each of the side walls and each of the end walls extend from said top wall and have a free end opposite said top wall. The first end wall is generally perpendicular to each of the side walls. The second end wall forms a beveled end arranged to be engaged in a guide rail for locking the window sash against pivotal movement.

Abstract: A seat assembly includes a seat tube in which a seat post is movably received therein which has a clamping member with a seat disposed thereto. The seat post has two plain portions defined diametrically opposite in an outer periphery thereof and the seat tube has two wedge-shaped recesses defined diametrically opposite in an inner periphery thereof so as to receive two wedge-shaped blocks therein. The seat post extends through a nut member which is threadedly mounted to the seat tube.

Abstract: A selectively adjustable apparatus permits the holding down and stabilizing of cartons in a continuous motion packaging machine as grouped articles are inserted into the cartons. The apparatus includes a pair of spaced parallel hold-down rails (56, 62) adapted to engage the tops of moving cartons with light force to hold the cartons down and inhibit their deformation as grouped articles are inserted with significant momentum into the cartons. A side rail (97) is provided and positioned to engage the back ends of the moving cartons to absorb the momentum of grouped articles as the articles are inserted into the cartons.