Abstract: The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.

Abstract: The present invention relates to a novel phytase enzyme, a novel isolated nucleic acid molecule coding the enzyme, and a novel Yersinia intermedia having phytase activity. Particularly, the present invention relates to the phytase having (a) Theoretical molecular weight 45.5 kDa, (b) high specific activity 3960±248 U/mg, (c) high stability at high temperature and wide pH, (d) optimal pH of 4.0-5.0, (e) optimal temperature of 50-60° C., (f) high resistance to pepsin and trypsin. The phytase is very suitable to be used in feed of monogastrics as feed additive. The present invention also relates to a recombinant vector comprising said nucleic acid molecule, a recombinant host cell (e.g., Pichia pastoris) harboring said recombinant vector, and a method for producing phytase using the recombinant host cell. The present invention further provides a feed additive comprising said phytase and/or host cells expressing a phytase as effective ingredient.

Abstract: A cutting tool with an adjustable cutting angle includes a first shank ended by a cutting blade, a second shank pivotally connected to the first shank so that the first and second shanks can be drawn toward or away mutually, an anvil provided on the second shank in positional correspondence to the cutting blade so as to work with the cutting blade and cut, wherein the anvil having a board-like body extending along the second shank is formed with an axial hole and edged with a curved sliding rim, and a pivotable retaining plate having its one end mounted around a shaft in the axial hole and its opposite end formed with a notch for engaging with the sliding rim, so that the pivotable retaining plate can pivot against the anvil, thereby making an angle between the retaining plate and the cutting blade, namely the cutting angle vary.

Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.

Abstract: A beveled-edge maker (1) for chamfering a workpiece (2), the tool comprising a knife assembly (4) adapted for attaching to a drive (5), and at least one guider (8) adapted such that the beveled-edge maker can be mounted to the edge of the workpiece and moved there along.

Abstract: Provided herein in certain embodiments are antibodies, antibody fragments, pharmaceutical compositions, methods for modulating the functions of estrogen receptor alpha 36, and methods for preventing and/or treating diseases mediated by estrogen receptor alpha 36.

Abstract: The present invention relates to a novel phytase enzyme, a novel isolated nucleic acid molecule coding the enzyme, and a novel Yersinia intermedia having phytase activity. Particularly, the present invention relates to the phytase having (a) Theoretical molecular weight 45.5 kDa, (b) high specific activity 3960±248 U/mg, (c) high stability at high temperature and wide pH, (d) optimal pH of 4.0-5.0, (e) optimal temperature of 50-60° C., (f) high resistance to pepsin and trypsin. The phytase is very suitable to be used in feed of monogastrics as feed additive. The present invention also relates to a recombinant vector comprising said nucleic acid molecule, a recombinant host cell (e.g., Pichia pastoris) harboring said recombinant vector, and a method for producing phytase using the recombinant host cell. The present invention further provides a feed additive comprising said phytase and/or host cells expressing a phytase as effective ingredient.

Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases mediated by estrogen receptor alpha 36, for preventing and/or treating osteoporosis, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.

Abstract: A ribbon gun includes a body having a trigger mechanism received therein and a magazine is received in the body portion. The magazine includes multiple cartridges and ribbons in the cartridges can be ejected by pulling the trigger mechanism. A cover has an outlet and is pivotably connected to the front end of the body. A locking member and a pivot are connected to the cover. The locking member secures the cover to the body, and the pivot is pivotably connected to the body. A pressing portion extends from a rear side thereof which faces interior of the body and a centering piece is located at a center of the pressing portion. The pressing portion presses the board of the magazine to push the cartridges toward the impact rod of the trigger mechanism. The centering piece is engaged with a recess in the board.

Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.

Abstract: A ribbon gun includes a body portion having a trigger mechanism received therein and a magazine can be received in the body portion and ejected by pulling the trigger mechanism. A cover has an opening and an annular flange extends from a side of the cover. The opening is enclosed by the annular flange and a barrel member is connected to the annular flange. A locking member and a lug are connected to the cover. The locking member has an engaging member extending therefrom which is removably engaged with a protrusion on the body portion to secure the cover, and a pivot extends from two sides of the lug so as to be pivotably connected to the body portion.

Abstract: An innovative cutter-grinder comprised of a base, a cutter holder, and a mobile base plate; the base plate being mounted with emery cloth before being placed on a deck of the frame to secure the emery cloth and allow easy replacement of the emery cloth; the cutter holder adapted with a roller at bottom retaining a blade for the user to hold the cutter holder to roll back and forth on the base plate to grind the cutter against the emery cloth; and an angle set plate being inserted onto slots respectively provided on both sides of the deck allowing the adjustment of the grinding angle.

Abstract: An angle adjustable sawing table adapted to allow the installation of a circular saw. Wood material is placed at pre-set geometric angles. One end of a gage is placed on a table, and another end of the gage is flush against a measurement member for adjustment to a preset angle.

Abstract: An angle adjustable sawing table allowing interchange of displacement among measurement members on the table to compromise the installation of the circular saw; the wood material being place at pre-set geometric angle; one end of the gage being placed on the table, and another of the gage flushed against the measurement member for adjustment to meet the present angle for easier cutting and time-saving.

Abstract: A carpenter's combination plane comprised of a basic holder and a blade holder, adapted with various holder accessories depending on the size of the work surface and the distance of reciprocal planing; other auxiliary accessories may be provided to the holder accessories to define the width, depth, inclined surface of the work surface or the polishing work surface.

Abstract: A carpenter's combination plane comprised of a basic holder and a blade holder, adapted with various holder accessories depending on the size of the work surface and the distance of reciprocal planing; other auxiliary accessories may be provided to the holder accessories to define the width, depth, inclined surface of the work surface or the polishing work surface.