Abstract: A guide RNA comprising: a gRNA spacer sequence at the 5? end of the guide RNA, wherein the spacer sequence is complementary to a target gene, a scaffold sequence that binds to Cas9, and an RNA capture and sequencing domain comprising: a barcode sequence, and a primer binding sequence; nucleic acids and vectors encoding the guide RNA; cells expressing the guide RNA; and a library comprising a plurality of guide RNAs. Also disclosed are methods of introducing a genetic perturbation into a cell, methods of assessing an effect of at least one genetic perturbation on RNA expression in a cell, methods of identifying nucleic acid sequences associated with a disease state and a method of identifying candidate therapeutic agents.

Abstract: The invention relates to methods for increasing nitrogen uptake, nitrogen assimilation, nitrogen use efficiency as well as yield in a plant, without affecting plant height, the method comprising increasing the expression or levels of a growth regulatory factor (GRF). Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

Abstract: An auto-feed pipe cleaner comprises a take-up unit comprising a wire drum and a spring wire; and a feed unit comprising a telescopic tube, a feeder for disposing a movable bearing and two fixed bearings, a tube handle disposed inside the telescopic tube and embedded with the feeder, and an elastic plate embedded inside the feeder. A user holds the telescopic tube with one hand, and holds a small handle of the wire drum with another hand to rotate the wire drum forwardly or reversely and drive the spring wire to rotate forwardly or reversely, and pushes the telescopic tube forward so that the movable bearing is pressed downward by the elastic plate and actuated with the fixed bearings to start feeding the spring wire or taking up the spring wire into the wire drum. When the telescopic tube is pulled backward, the movable bearing is not actuated.

Abstract: In an application remodeling method, an application management system obtains an environment variable of an application in a runtime environment and a code package of the application. The system then obtains a remodeling result of the application based on the environment variable and the code package. The remodeling result includes an image set of the application, the image set includes a plurality of images, and a container created based on each image is configured to execute some modules of the application. Thus, automatic application remodeling is implemented based on the environment variable and the code package of the application.

Abstract: Aspects of the present disclosure relate to a providing related content recommendations in response to a user search query by supervising the training of pair embeddings using contrastive learning and pairwise co-click signals. The approach combines a two tower model architecture with a cascaded multilayer perceptron model to enable the adoption of variable combinations of input features and more representative learned pair embeddings. The learned embeddings undergo supervised contrastive loss training to generate a related content recommendation model, which is subsequently evaluated using both online and offline metrics. The related content recommendation model can provide results to search queries that improve recommendation quality and increase user engagement, thereby ultimately enhancing long term user experience.

Abstract: Embodiments of the disclosure provide systems and methods for performing motion transfer using a learning model. An exemplary system may include a communication interface configured to receive a first image including a first movable object and a second image including a second movable object. The system may also include at least one processor coupled to the communication interface. The at least one processor may be configured to extract a first set of motion features of the first movable object from the first image using a first encoder of the learning model and extract a first set of static features of the second movable object from the second image using a second encoder of the learning model. The at least one processor may also be configured to generate a third image by synthesizing the first set of motion features and the first set of static features.

Abstract: A computer-implemented technique performs machine learning that bypasses the traditional design of loss functions. The technique includes receiving plural instances of gradient objective information. Each of the plural instances includes a particular combination of plural gradient elements. The technique produces plural sets of machine-trained parameter values using the plural respective instances of gradient objective information. The technique performs this operation based on the plural instances of gradient objective information as given, without calculating the plural instances of gradient objective information using loss functions. The technique then measures performance of the plural sets of machine-trained parameter values in an application system. Based on the measured performance, the technique provides output information that identifies a particular set of machine-trained parameter values that satisfies a prescribed test.

Abstract: A power-converter module has a switching Printed Circuit Board (PCB) with power transistors generating heat. Ground, an input power supply, and an output power supply to the power transistors connect through metal traces on the switching PCB directly to interposer heat sinks that are soldered to the switching PCB. Copper bars attached to the bottoms of interposer heat sinks fit in holes in a system PCB to make connections. The metal traces and interposer heat sinks carry supply or ground currents and heat away from the power transistors. These power and ground currents continue from the interposer heat sinks through the copper bars to the system PCB. An interposer PCB has soler pads and solder balls to carry control signals from the system PCB to the switching PCB, bypassing the interposer heat sinks. Copper bars can be sintered, soldered, or welded to or integral with the interposer heat sinks.

Abstract: Systems and methods directed to returning personalized image-based search results are described. In examples, a query including an image may be received, and a personalized item embedding may be generated based on the image and user profile information associated with a user. Further, a plurality of candidate images may be obtained based on the personalized item embedding. The candidate images may then be ranked according to a predicted level of user engagement for a user, and then diversified to ensure visual diversity among the ranked images. A portion of the diversified images may then be returned in response to an image-based search.

Abstract: Embodiments of the present disclosure provide a method and apparatus for processing a multi-language text. According to embodiments of the present disclosure, the multi-language text including contents in a plurality of languages may be encoded with a Unicode. The method further comprises splitting the multi-language text into a plurality of parts based on the Unicode of the multi-language text, contents of the plurality of parts having different languages. In addition, the multi-language text may also be processed based on the plurality of parts.

Abstract: A power-converter module has a switching Printed Circuit Board (PCB) with power transistors that generate heat. Ground, an input power supply, and an output power supply to the power transistors connect through metal traces on the switching PCB directly to interposer heat sinks that are soldered between the switching PCB and a system PCB. The metal traces and interposer heat sinks carry both supply or ground currents and heat away from the power transistors. These power and ground currents continue from the interposer heat sinks to the system PCB through direct solder joints between the system PCB and the interposer heat sinks. An interposer PCB has a same thickness as the interposer heat sinks and carries control signals from the system PCB to the switching PCB, bypassing the interposer heat sinks. The interposer heat sinks have an interposer portion soldered between the PCBs and fins beyond the switching PCB footprint.

Abstract: A power-converter module has a switching Printed Circuit Board (PCB) with power transistors that generate heat. Ground, an input power supply, and an output power supply to the power transistors connect through metal traces on the switching PCB directly to interposer heat sinks that are soldered between the switching PCB and a system PCB. The metal traces and interposer heat sinks carry both supply or ground currents and heat away from the power transistors. These power and ground currents continue from the interposer heat sinks to the system PCB through direct solder joints between the system PCB and the interposer heat sinks. An interposer PCB has a same thickness as the interposer heat sinks and carries control signals from the system PCB to the switching PCB, bypassing the interposer heat sinks. The interposer heat sinks have an interposer portion soldered between the PCBs and fins beyond the switching PCB footprint.

Abstract: The invention relates to methods for increasing plant yield, and in particular grain yield by reducing or abolishing the expression and/or activity of OTUB1 in a plant. Also described are genetically altered plants characterised by the above phenotype and methods of producing such plants.

Abstract: The present disclosure provides methods and apparatuses for providing prompts in speech recognition results in real time. A current speech input in an audio stream for a target event may be obtained. A current utterance text corresponding to the current speech input may be identified. A prompt may be generated based at least on the current utterance text, the prompt comprising at least one predicted subsequent utterance text sequence. A speech recognition result for the current speech input may be provided, the speech recognition result comprising the current utterance text and the prompt.

Abstract: A voltage regulation apparatus and an overcurrent protection method are disclosed. The voltage regulation apparatus includes a current detection control circuit, a power stage circuit, a voltage input terminal, and a voltage output terminal. The power stage circuit includes at least one transistor. Because a current parameter indicates a load current of the at least one transistor, and a plurality of preset overcurrent protection thresholds are dynamic overcurrent protection thresholds obtained after being preset based on temperature information and the like, after obtaining the current parameter, the current detection control circuit compares the current parameter with the plurality of preset overcurrent protection thresholds, to output a control signal, to implement a limiting operation on the current parameter.

Abstract: A repairing tool for an electric wire threading head for pressing and squeezing a drawing-in wire of the electric wire includes a first holding part, a second holding part opposite to the first holding part, and two positioning bolts for fastening the first holding part and the second holding part. A first half screw hole and a second half screw hole are protrudingly formed on the first holding part and the second holding part to form a complete screw hole. The drawing-in wire is pressed and squeezed through the positive rotation or reverse rotation of the repairing tool to form an external screw thread part and increase a screw thread area, and the surface of the external screw thread part is applied with instant dry adhesive and rotated into a pulling head, so that the drawing-in wire is closely adhered to the pulling head and tensile strength is improved.

Abstract: An active filter reduces Electro-Magnetic Interference (EMI) created by current flowing through a power line. The active filter connects to the power line at a single node through a connection capacitor. A sense current flows through the connection capacitor when the power line current changes. This sense current is applied to a gain control circuit having cross-coupled PNP transistors that drive currents to both terminals of a variable capacitor. The variable capacitor converts these currents to a voltage that is injected back into the power line through the connection capacitor as an injected compensation voltage that compensates for the sensed current.

Abstract: A reciprocating pump-type pipe dredging device comprises an inflator and a pipe dredging portion detachably assembled with the inflator. The inflator includes a cylinder, an inflator handle and a first assembly portion. The pipe dredging portion includes a suction disc and a flexible pipe. The suction disc includes a second assembly portion joined with the first assembly portion, a disc connected to one end of the second assembly portion, and a third assembly portion extending toward an inner top end of the disc and corresponding to the second assembly portion. The flexible pipe includes a pipe and a plurality of layered flexible ring plates. One end of the pipe is provided with a fourth assembly portion joined with the third assembly portion, and the inflator and the pipe dredging portion are formed a continuous passage thereinside after assembling.

Abstract: A circuit design includes a flexible film, an electrode pattern, and a connecting circuit. The flexible film has a visible area and a bending area and includes an external conductive connection. The electrode pattern is disposed in the visible area of the flexible film. The connecting circuit is electrically connected to the electrode pattern and disposed in the bending area of the flexible film. The bending area has a first portion and a second portion. The first portion is located between the visible area and the second portion. A width of one end of the second portion connected to the first portion is smaller than a width of the first portion. The external conductive connection is electrically connected to the connecting circuit and located at another end of the second portion.

Abstract: A switch-mode power supply includes a first switch circuit, at least one second switch circuit, a switch control circuit, a first inductor switching circuit, a coupled inductor, a voltage input end, and a voltage output end. The coupled inductor in the switch-mode power supply may be connected to the first switch circuit, to implement signal transmission between the coupled inductor and the first switch circuit. Signal transmission between the coupled inductor and the second switch circuit may be implemented under control of the first inductor switching circuit. Alternatively, the signal transmission between the coupled inductor and the second switch circuit may be disconnected under the control of the first inductor switching circuit.