Patents by Inventor Kunal Madhav Jagtap

Kunal Madhav Jagtap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of bosentan
    Patent number: 9139537
    Abstract: A novel ammonium salt of Bosentan of formula (VIII); has been disclosed. The salt may be either crystalline or amorphous or mixture of Crystalline and amorphous form. A novel single pot process for the preparations of ammonium salt of Bosentan has been disclosed. The process comprises reacting the 4,6-dichloro-5-(2-methoxyphenoxy)-2,2?-bipyrimidine with 4-tert-butylbenzenesulfonamide in the presence of solvent and a base; adding ethylene glycol to the reaction mass and isolating the ammonium salt of Bosentan. The ammonium salt of Bosentan is converted into Bosentan and further into Bosentan Monohydrate which are substantially free from dimer impurity and 6-hydroxy impurity.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: September 22, 2015
    Assignee: Megafine Pharma(P) Ltd.
    Inventors: Vijayavitthal Thippannachar Mathad, Navnath Chintaman Niphade, Kunal Madhav Jagtap, Chandrashekar Trimbak Gaikwad
  • Novel Process For Preparation Of Bosentan
    Publication number: 20130296560
    Abstract: A novel ammonium salt of Bosentan of formula (VIII); has been disclosed. The salt may be either crystalline or amorphous or mixture of Crystalline and amorphous form. A novel single pot process for the preparations of ammonium salt of Bosentan has been disclosed. The process comprises reacting the 4,6-dichloro-5-(2-methoxyphenoxy)-2,2?-bipyrimidine with 4-tert-butylbenzenesulfonamide in the presence of solvent and a base; adding ethylene glycol to the reaction mass and isolating the ammonium salt of Bosentan. The ammonium salt of Bosentan is converted into Bosentan and further into Bosentan Monohydrate which are substantially free from dimer impurity and 6-hydroxy impurity.
    Type: Application
    Filed: March 28, 2011
    Publication date: November 7, 2013
    Applicant: Megafine Pharma (P) Ltd.
    Inventors: Vijayavitthal Thippannachar Mathad, Navnath Chintaman Niphade, Kunal Madhav Jagtap, Chandrashekar Trimbak Gaikwad
  • Method for the preparation of solifenacin and intermediate thereof
    Patent number: 8283470
    Abstract: A method for the preparation of solifenacin by reacting quinuclidin-3-ol and bis (aryl) carbonate to form (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa); and treating (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa) with (1S)-1-phenyl- 1,2,3,4-tetrahydroisoquinoline of formula (V) in an inert atmosphere to form a Solifenacin base, which is converted into its pharmaceutically acceptable salts. The invention also provides a compound, (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa), which is used as an intermediate for the preparation of Solifenacin base and a process for the preparation thereof.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: October 9, 2012
    Assignee: Megafine Pharma(P) Ltd.
    Inventors: Vijayvitthal Thippannachar Mathad, Navnath Chintaman Niphade, Anil Chaturlal Mali, Kunal Madhav Jagtap, Bhushan Sudhakar Pandit, P. Raghvendra Kumar, Shashikant Baburao Landge