Abstract: Time-resolved optical tomography systems using a short pulse laser, may be used in detection and treatment of cancer and tumors. Information is conveyed about tissue interior by the temporal variation of the observed scattered, and reflected measured when short-pulse lasers interact with scattering-absorbing media like tissue. Multiple scattering-induced temporal signature that persists for time periods greater than the duration of the source pulse and is a function of the source pulse width, the scattering and absorbing properties of the medium, and the location in the medium where the properties undergo changes. If the detection is carried out on the same short time scale (comparable to the order of the pulse width), the signal continues to be observed even for long durations after the pulse has been off due to the time taken for the photons to migrate to the detector after multiple scattering in the tissue media.

Abstract: Time-resolved optical tomography systems using a short pulse laser, may be used in detection and treatment of cancer and tumors. Information is conveyed about tissue interior by the temporal variation of the observed scattered, and reflected measured when short-pulse lasers interact with scattering-absorbing media like tissue. Multiple scattering-induced temporal signature that persists for time periods greater than the duration of the source pulse and is a function of the source pulse width, the scattering and absorbing properties of the medium, and the location in the medium where the properties undergo changes. If the detection is carried out on the same short time scale (comparable to the order of the pulse width), the signal continues to be observed even for long durations after the pulse has been off due to the time taken for the photons to migrate to the detector after multiple scattering in the tissue media.

Abstract: A method of performing a diagnostic procedure for early cancer detection includes using an ultra-short pulsed laser and measuring time-resolved optical signals to provide information about localization and characterization of tissue inhomogeneities.

Abstract: The subject invention pertains to a method and apparatus for generation and/or delivery of x-ray irradiation. The subject invention can be used to deliver x-ray irradiation to an artery in order to prevent restenosis in the artery. For example, a short pulse laser generated ionizing dose of x-ray irradiation can be effectively delivered to the arterial wall using hollow waveguides. The delivery of such a dose can help to prevent restenosis. The use of short pulse x-rays can allow energy to be precisely delivered, and can reduce diffusion of the energy to nearby normal tissue during the exposure. The arterial walls can be irradiated from a cylindrical or conical symmetric mirrored reflective end tip mounted on the end of a hollow waveguide. The subject invention also pertains to a method and apparatus for delivery of x-ray radiation with respect to medical therapies such as tumor necrosis.