Abstract: Embodiments of the present disclosure include systems and methods of handling ink using a movable spittoon platform. A frame defines at least a reservoir portion and a side wall protrusion adjacent the reservoir portion. A shuttle includes a platform slidably movable between a first position, in which the platform is biased to extend outwardly from an end portion of the shuttle, and a second position, in which the platform becomes retracted relative to the end portion of the shuttle. The shuttle is slidably movable relative to the frame toward the spittoon portion wherein, upon releasable contact of the platform against the protrusion, the platform moves from the first portion into the second portion to scrape ink off the platform into the reservoir portion below the shuttle.

Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.

Abstract: This invention relates to an improved process for preparing substantially pure simvastatin (I), chemically known as (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2-H-pyran-2-yl]ethyl]-3 ,7-dimeth-yl-1,2,3,7,8,8a-Hexahydronaphthalen-1-yl2,2-dimethyl butanoate, which comprises of: a) treating lovastatin (II) with an alkali metal hydroxide in a chosen suitable alcoholic solvent followed by relactonization to obtain the diol lactone intermediate (III) in a single vessel. b) selective silylation of 4-hydroxy group of diol lactone intermediate (III) with a chosen suitable silylating reagent to obtain mono silylated intermediate diol lactone (IV).

Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.

Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.

Abstract: A network telephony system is provided which enables unified messaging services. The system generally includes at least one user agent operatively coupled to a data network and a signalling server operatively coupled to the data network. The user agents are telephony endpoints, such as standalone Internet telephony appliances or personal computers with appropriate telephony software. A messaging server is provided which is operatively coupled to the data network and is responsive to the signaling server. The system also includes a media server which is operatively coupled to the network and includes computer data storage media for storing message files. The media server is responsive to the messaging server and, on occurrence of a messgae condition, is directly accessible to a calling party to store a message file for subsequent retrieval by a called party.

Abstract: A conferencing server is provided for a data network telephony system for facilitating multi-party call conferencing. The conferencing server generally includes a session initiation protocol (SIP) signaling interface and a media conferencing module. The media conferencing module includes a number of selectable media decoders compliant with known media CODEC protocols, such as G.711. A number of media stream queues s are selectively coupled to the media decoders for storing the decoded incoming media streams. A jitter correction processor is provided to compensate for arrival time jitter in the data stored in the media stream queues. A mixer, which receives the jitter corrected data from each of the queues, generates an aggregate conferencing stream of all active participants and generates individual participant conference streams for each active participant in the conference.

Abstract: A network telephony system is provided which enables unified messaging services. The system generally includes at least one user agent (102,104) operatively coupled to a data network (106) and a signalling server operatively coupled to the data network (106). The user agents (102,104) are telephony endpoints, such as standalone Internet telephony appliances or personal computers with appropriate telephony software. A messaging server (110) is provided which is operatively coupled to the data network (106) and is responsive to the signaling server (108). The system also includes a media server (112A,112B) which is operatively coupled to the network and includes computer data storage media for storing message files. The media server is responsive to the messaging server (110) and, on occurrence of a message condition, is directly accessible to a calling party to store a message file for subsequent retrieval by a called party.

Abstract: A device verifies whether signaled pinholes in a Session Initiation Protocol (SIP)-based perimeter protection device are open, calculates a fine granularity pinhole opening delay of the SIP-based perimeter protection device, and calculates a fine granularity pinhole closing delay of the SIP-based perimeter protection device.

Abstract: A method of processing a call request to a callee in a network telephony system is provided which includes mapping a hostname portion of a callee address to a canonical form of the hostname and determining a canonical form of a username portion of a callee address. The canonical form of the user identity of the callee is then used as an index to a user database to retrieve a callee database record. The callee database record is then used to determine call routing based on the retrieved callee database record, such as user location, preferences and policy data stored in the record. The method is generally performed by a signaling server in the network, such as a SIP proxy server. The signaling server can also provide security features such as caller authentication. A scalable signaling and routing architecture is also provided.

Abstract: A mobile node includes a processor, a network interface, and a storage device having computer program code for execution by the processor. The computer program code includes a network layer for transmitting and receiving packets and an intermediate driver that transmits packets to the network layer and receives packets from the network layer using a virtual internet protocol (IP) address to identify the mobile node. The intermediate driver transmits packets to the network interface and receives packets from the network interface using a routable actual IP address to identify the mobile node. The intermediate driver permits the actual IP address to change when the mobile node moves from a first subnet to a second subnet without a corresponding change in the virtual IP address. A corresponding NAT associates the virtual IP address with a second actual IP address when the NAT is notified that the mobile node is in the second subnet.

Abstract: A network telephony system is provided which enables unified messaging services. The system generally includes at least one user agent (102,104) operatively coupled to a data network (106) and a signalling server operatively coupled to the data network (106). The user agents (102,104) are telephony endpoints, such as standalone Internet telephony appliances or personal computers with appropriate telephony software. A messaging server (110) is provided which is operatively coupled to the data network (106) and is responsive to the signaling server (108). The system also includes a media server (112A,112B) which is operatively coupled to the network and includes computer data storage media for storing message files. The media server is responsive to the messaging server (110) and, on occurrence of a messgae condition, is directly accessible to a calling party to store a message file for subsequent retrieval by a called party.

Abstract: A conferencing server is provided for a data network telephony system for facilitating multi-party call conferencing. The conferencing server generally includes a session initiation protocol (SIP) signaling interface and a media conferencing module. The media conferencing module includes a number of selectable media decoders compliant with known media CODEC protocols, such as G.711. A number of media stream queues s are selectively coupled to the media decoders for storing the decoded incoming media streams. A jitter correction processor is provided to compensate for arrival time jitter in the data stored in the media stream queues. A mixer, which receives the jitter corrected data from each of the queues, generates an aggregate conferencing stream of all active participants and generates individual participant conference streams for each active participant in the conference.