Patents by Inventor Kuniaki Kawamura
Kuniaki Kawamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8637539Abstract: The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.Type: GrantFiled: August 18, 2005Date of Patent: January 28, 2014Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Takashi Endo, Kuniaki Kawamura, Toshiaki Tanaka, Tomohiko Suzuki, Tsutomu Suzuki, Yasushi Kuraishi, Kimiyasu Shiraki
-
Patent number: 8470845Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed.Type: GrantFiled: November 4, 2005Date of Patent: June 25, 2013Assignee: Toray Industries, Inc.Inventors: Naoki Izumimoto, Kuniaki Kawamura, Toshikazu Komagata, Tadatoshi Hashimoto, Hiroshi Nagabukuro
-
Patent number: 7652025Abstract: A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid ? receptor agonist compound such as (?)-17-(cyclopropylmethyl)-3,14?-dihydroxy-4,5?-epoxy-6?[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid ? receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.Type: GrantFiled: May 8, 2002Date of Patent: January 26, 2010Assignee: Toray Industries, Inc.Inventors: Tomohiko Suzuki, Hideaki Inada, Yoshitaka Yoshizawa, Kuniaki Kawamura, Toshiaki Tanaka
-
Patent number: 7602085Abstract: A system for utilizing coal energy includes a thermal power generator near a coal field area that converts coal energy of the coal field area located remotely from a demand end to electric energy. It also includes an alternating current load at a demand end side, an alternating current power distribution network, and an electric power transmission mechanism that transmit electric energy from the thermal power generator to the power distribution network. The electric power transmission mechanism is a combination of super conductive power transmitting system that transmit direct current electricity with small transmission loss utilizing super conductive power transmitting cables and a conventional power distribution network operating at ambient temperatures.Type: GrantFiled: August 3, 2005Date of Patent: October 13, 2009Assignee: Mayekawa Mfg. Co., Ltd.Inventors: Kuniaki Kawamura, Masamitsu Ikeuchi, Akito Machida
-
Patent number: 7370481Abstract: Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that the temperature of the nitrogen reaches the triple point of nitrogen by lowering the temperature to thereby produce solid nitrogen by keeping the temperature at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel.Type: GrantFiled: September 16, 2006Date of Patent: May 13, 2008Assignee: Mayekawa Mfg. Co., Ltd.Inventors: Kuniaki Kawamura, Akito Machida, Masamitsu Ikeuchi, Kazuhiro Hattori, Kouichi Matsuo, Hideharu Yanagi
-
Patent number: 7320984Abstract: The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(?O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.Type: GrantFiled: October 8, 2003Date of Patent: January 22, 2008Assignee: Toray Industries, Inc.Inventors: Naoki Izumimoto, Koji Kawai, Kuniaki Kawamura, Morihiro Fujimura, Toshikazu Komagata
-
Publication number: 20070299100Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed.Type: ApplicationFiled: November 4, 2005Publication date: December 27, 2007Inventors: Naoki Izumimoto, Kuniaki Kawamura, Toshikazu Komagata, Tadatoshi Hashimoto, Hiroshi Nagabukuro
-
Publication number: 20070006599Abstract: Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that the temperature of the nitrogen reaches the triple point of nitrogen by lowering the temperature to thereby produce solid nitrogen by keeping the temperature at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel.Type: ApplicationFiled: September 16, 2006Publication date: January 11, 2007Applicant: MAYEKAWA MFG. CO., LTD.Inventors: Kuniaki KAWAMURA, Akito MACHIDA, Masamitsu IKEUCHI, Kazuhiro HATTORI, Kouichi MATSUO, Hideharu YANAGI
-
Patent number: 7155930Abstract: Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that a temperature of the nitrogen is reached to the triple point of nitrogen by lowering temperature thereby and solid nitrogen is produced by keeping at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel.Type: GrantFiled: June 23, 2005Date of Patent: January 2, 2007Assignee: Mayekawa Mfg. Co., Ltd.Inventors: Kuniaki Kawamura, Akito Machida, Masamitsu Ikeuchi, Kazuhiro Hattori, Kouichi Matsuo, Hideharu Yanagi
-
Publication number: 20060094741Abstract: The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.Type: ApplicationFiled: August 18, 2005Publication date: May 4, 2006Applicant: Toray Industries, Inc., a corporation of JapanInventors: Hiroshi Nagase, Takashi Endo, Kuniaki Kawamura, Toshiaki Tanaka, Tomohiko Suzuki, Tsutomu Suzuki, Yasushi Kuraishi, Kimiyasu Shiraki
-
Publication number: 20060056120Abstract: A system for utilizing coal energy includes a thermal power generator near a coal field area that converts coal energy of the coal field area located remotely from a demand end to electric energy. It also includes an alternating current load at a demand end side, an alternating current power distribution network, and an electric power transmission mechanism that transmit electric energy from the thermal power generator to the power distribution network. The electric power transmission mechanism is a combination of super conductive power transmitting system that transmit direct current electricity with small transmission loss utilizing super conductive power transmitting cables and a conventional power distribution network operating at ambient temperatures.Type: ApplicationFiled: August 3, 2005Publication date: March 16, 2006Applicant: MAYEKAWA MFG. CO., LTD.Inventors: Kuniaki Kawamura, Masamitsu Ikeuchi, Akito Machida
-
Publication number: 20060040970Abstract: The invention provides a morphinan derivative of the Formula (I): (wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(?O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like) or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.Type: ApplicationFiled: October 8, 2003Publication date: February 23, 2006Applicant: Toray Industries, Inc.Inventors: Naoki Izumimoto, Koji Kawai, Kuniaki Kawamura, Morihiro Fujimura, Toshikazu Komagata
-
Publication number: 20060000222Abstract: Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that a temperature of the nitrogen is reached to the triple point of nitrogen by lowering temperature thereby and solid nitrogen is produced by keeping at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel.Type: ApplicationFiled: June 23, 2005Publication date: January 5, 2006Applicant: Mayekawa Mfg. Co., Ltd.Inventors: Kuniaki Kawamura, Akito Machida, Masamitsu Ikeuchi, Kazuhiro Hattori, Kouichi Matsuo, Hideharu Yanagi
-
Patent number: 6889520Abstract: The object of the invention is to provide a thermal complementary (combination of heat supply and heat discharge) system which can complement heat without the restriction of area of a region to be supplied with heat. An endless multiplex helical loop is formed to complement the heat produced in a region such as plants and regional facilities on a reciprocal basis, and the water is not circulated forcibly but achieves heat transfer in the helical loop. Liquid or slurry-like water is sealed in the annular endless channel (endless loop) without forcibly circulated. Therefore, loop diameter of the annular endless channel, that means the area of the region, is not limited. The water forms temperature zones in the endless helical loop, the temperature being different per each component loop. Distributed cryogenic sources and thermal sources are thermally connected to said multiplex helical loop so that heat (i.e. water) can be taken in or discharged to or from said cryogenic or thermal sources.Type: GrantFiled: December 12, 2001Date of Patent: May 10, 2005Assignee: Mayekawa Mfg. Co., Ltd.Inventors: Makoto Sano, Kuniaki Kawamura, Junji Matsuda, Katsumi Fujima, Takanori Kudo, Youichi Kawazu, Choiku Yoshikawa, Syuji Fukano
-
Patent number: 6803366Abstract: Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 30, 2002Date of Patent: October 12, 2004Assignee: Toray Industries, Inc.Inventors: Kuniaki Kawamura, Hiroshi Nagase, Noriyuki Hirano, Junzo Kamei
-
Publication number: 20040147536Abstract: A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid &kgr; receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14&bgr;-dihydroxy-4,5&agr;-epoxy-6&bgr;[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid &kgr; receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.Type: ApplicationFiled: December 18, 2003Publication date: July 29, 2004Inventors: Tomohiko Suzuki, Hideaki Inada, Yoshitaka Yoshizawa, Kuniaki Kawamura, Toshiaki Tanaka
-
Publication number: 20040011074Abstract: The object of the invention is to provide a thermal complementary (combination of heat supply and heat discharge) system which can complement heat without the restriction of area of a region to be supplied with heat. An endless multiplex helical loop is formed to complement the heat produced in a region such as plants and regional facilities on a reciprocal basis, and the water is not circulated forcibly but achieves heat transfer in the helical loop.Type: ApplicationFiled: May 13, 2003Publication date: January 22, 2004Inventors: Makoto Sano, Kuniaki Kawamura, Junji Matsuda, Katsumi Fujima, Takanori Kudo, Youichi Kawazu, Choiku Yoshikawa, Syuji Fukano
-
Publication number: 20030186986Abstract: Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 30, 2002Publication date: October 2, 2003Inventors: Kuniaki Kawamura, Hiroshi Nagase, Noriyuki Hirano, Junzo Kamei
-
Patent number: 6583151Abstract: A method for treating drug dependence comprising administering, as the active ingredient, an opioid &kgr; receptor agonist of a compound represented by the following formula, is disclosed wherein A and the R terms are herein defined.Type: GrantFiled: July 12, 1999Date of Patent: June 24, 2003Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Takashi Endoh, Tsutomu Suzuki, Kuniaki Kawamura, Koji Oshima, Hideaki Inada
-
Publication number: 20020156750Abstract: The present invention provides a business system for supplying heat/cold heat, in which a group of heat/cold heat cycle units which are constructed as portable, integral ones having high reliability and maintainability and equipped with efficient evaporative condensers are provided, those units are put to lease to users, the units are put under good management through a network including the Internet, optimal operation thereof are enabled, heat/cold heat energy is generated effectively for the users, and business of supplying heat/cold heat energy is made possible by including the usage charge of the heat/cold heat energy in the rental of the heat/cold heat cycle units, user's factories A, B, C, . . . which receive the supply of the heat/cold heat energy being connected to the Internet 11 by the medium of browsers 15, 15, . . . , the factories A, B, C, . . . renting heat/cold heat cycle units 10a, 10b, 10c, a unit monitoring depot 16 for remote-monitoring the operation conditions, etc.Type: ApplicationFiled: April 24, 2001Publication date: October 24, 2002Inventors: Kuniaki Kawamura, Shinjiro Akaboshi