Abstract: The invention relates to an analysis method which can conduct analysis on low molecular weight compound in a sample containing water-soluble polymer and low molecular weight compound under isocratic conditions without being affected by proteins or the like and in which water-soluble polymer and low molecular weight compound can be separated efficiently and to a column for such an analysis by high performance liquid chromatography, packed with a packing material comprising a crosslinked organic polymer compound obtained by polymerizing glycerin dimethacrylate at 90 mass % or more as starting material, having the exclusion limit molecular weight measured with pullulan of 30000 or less but 3000 or more and having a mass average particle diameter of 0.1 to 100 ?m.

Abstract: Disclosed is an organic polymer monolith comprising a monomer unit derived from a monomer having a hydroxyl group and/or an amide group in an amount of not less than 20% by mass, and/or a monomer unit derived from a crosslinking agent in an amount of not less than 50% by mass, having throughpores with a mode diameter, as measured by mercury porosimetry, of 0.5 to 10 mm and mesopores with a mode diameter, as measured by a BET method, of 2 to 50 nm, and having a specific surface area, as measured by a BET method, of not less than 50 m2/g. Also disclosed are a process for preparing the organic polymer monolith and a chemical substance separating device using the organic polymer monolith.

Abstract: A particulate hydrophobic polymer produced by reacting (A) a particulate crosslinked polymer having a hydroxyl group with (B) a crosslinkable epoxy compound, hydrolyzing the epoxy bonds, and then reacting the obtained compound having a hydroxyl group with (C) an epoxy compound having from 6 to 40 carbon atoms in total, a production process therefor, a column for reversed-phase liquid chromatography, and an analysis method using the column. By using the particulate hydrophobic polymer of the present invention having a remarkably high acid/alkali resistance, a sharp chromatogram for polycyclic aromatic compounds is obtainable with the swelling and shrinkage of the particulate polymer itself reduced and without reducing the column efficiency among various solvents even when the eluent in the column is variously exchanged.

Abstract: An object of the present invention is to prevent an isolation of carboxyl group caused by hydrolysis of ester bond, which occurs when a polymer particle containing an ester bond is used in the presence of a strongly acidic or strongly alkaline solution to thereby improve the acid Ealkali durability of the polymer particle. When a polymer particle containing an ester bond is treated with an acid or alkali hydrous solution and thereby an ester bond which is located and exposed on the surface of the particle and is readily hydrolyzed is previously hydrolyzed to isolate a carboxyl group and then the free carboxyl group is capped by amidation, to thereby dissolve the above problem.

Abstract: Disclosed are (1) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, (2) an alkali-resistant, high-strength porous polymer particle having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, a part of the ester bonds being saponified and converted to a hydroxyl group(s), (3) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, the porous polymer particles being treated with an alkaline solution to generate a hydroxyl and/or a carboxyl group on a surface of the substrate, (4) an anion exchanger comprising any one of the particles (1) to (3) above, (5) a packing material for anion chromatography comprising the anion exchanger (4) above, (6) a column for anion chromatography using the anion exchanger (4) above, and (7) a method for meas

Abstract: A particulate hydrophobic polymer produced by reacting (A) a particulate crosslinked polymer having a hydroxyl group with (B) a crosslinkable epoxy compound, hydrolyzing the epoxy bonds, and then reacting the obtained compound having a hydroxyl group with (C) an epoxy compound having from 6 to 40 carbon atoms in total, a production process therefor, a column for reversed-phase liquid chromatography, and an analysis method using the column. By using the particulate hydrophobic polymer of the present invention having a remarkably high acid/alkali resistance, a sharp chromatogram for polycyclic aromatic compounds is obtainable with the swelling and shrinkage of the particulate polymer itself reduced and without reducing the column efficiency among various solvents even when the eluent in the column is variously exchanged.

Abstract: The present invention relates to a packing agent for reversed phase liquid chromatography, including crosslinked polymer base particles which are obtained by aqueous suspension-polymerization of a crosslinkable vinyl ester or vinyl ether having a hydroxyl group within the molecule and which has an exclusion limit molecular weight of 100,000 or less in terms of standard polystyrene by size exclusion chromatography, wherein an acyl group having from 4 to 24 carbon atoms is ester-bonded to a part of hydroxyl groups in the crosslinked polymer base particles. The present invention also provides a production process of a packing agent, a column for reversed phase liquid chromatography using the packing agent, and an analysis method by reversed phase liquid chromatography using the packing agent.

Abstract: A porous copolymer particle having a particle size of from 0.1 to 2,000 &mgr;m and a permanent pore size of from 2 to 800 nm comprising (i) a monomer containing from 5 to 60 wt % of a monomer (A) selected from N-vinylcarboxylic acid amides represented by formula (I): wherein R1 represents a hydrogen atom or a methyl group, and R2 represents a hydrogen atom, a C1-C8 alkyl group, a phenyl group or a phenyl group substituted with a methyl group or an ethyl group and (ii) from 40 to 95 wt % of a copolymerizable monomer (B) which contains a crosslinking monomer.

Abstract: Disclosed are (1) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, (2) an alkali-resistant, high-strength porous polymer particle having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, a part of the ester bonds being saponified and converted to a hydroxyl group(s), (3) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, the porous polymer particles being treated with an alkaline solution to generate a hydroxyl and/or a carboxyl group on a surface of the substrate, (4) an anion exchanger comprising any one of the particles (1) to (3) above, (5) a packing material for anion chromatography comprising the anion exchanger (4) above, (6) a column for anion chromatography using the anion exchanger (4) above, and (7) a method for meas

Abstract: The present invention relates to a packing agent for reversed phase liquid chromatography, including crosslinked polymer base particles which are obtained by aqueous suspension-polymerization of a crosslinkable vinyl ester or vinyl ether having a hydroxyl group within the molecule and which has an exclusion limit molecular weight of 100,000 or less in terms of standard polystyrene by size exclusion chromatography, wherein an acyl group having from 4 to 24 carbon atoms is ester-bonded to a part of hydroxyl groups in the crosslinked polymer base particles. The present invention also provides a production process of a packing agent, a column for reversed phase liquid chromatography using the packing agent, and an analysis method by reversed phase liquid chromatography using the packing agent.

Abstract: A preparation for administration to animals, comprising a sparingly soluble L-ascorbic acid-2-phosphoric ester salt having a solubility in water of 10 wt % or less, the solubility being a value obtained by placing 100 g of purified water in a 200 ml-volume beaker, stirring the water while keeping the temperature at 20° C., adding 0.1 g of the L-ascorbic acid-2-phosphoric ester salt every 5 minutes by taking care not to cause gelation, and 30 minutes after the addition of L-ascorbic acid-2-phosphoric ester salt when the undissolved L-ascorbic acid-2-phosphoric ester salt is observed visually in the aqueous solution, determining the amount in weight percentage of L-ascorbic acid-2-phosphoric ester salt added based on water, and a method for feeding animals, using the preparation.

Abstract: A process of purifying L-ascorbic acid 2-phosphate is disclosed, comprising passing a solution containing L-ascorbic acid 2-phosphate through a column of a basic anion exchanger resin whose ion-exchange groups consist essentially of a primary amine group, a secondary amine group, a tertiary amine group or a mixture thereof, and eluting the L-ascorbic acid 2-phosphate with an aqueous solution of a mineral acid or an inorganic salt. L-ascorbic acid 2-phosphate can be isolated at a high efficiency through easy steps.