Patents by Inventor Kunihiko Fujii

Kunihiko Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8946264
    Abstract: The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) ?. A compound represented by the general formula (I): [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.
    Type: Grant
    Filed: October 20, 2012
    Date of Patent: February 3, 2015
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Makoto Mori
  • Patent number: 8927536
    Abstract: The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11?-hydroxysteroid dehydrogenase type 1: General formula (I) wherein R1 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from substituent group A or a heterocyclic group that may be substituted with 1 to 4 group(s) independently selected from substituent group A; R2 independently represents a halogen atom or a C1-C6 alkyl group; n represents an integer of 0 to 2; and substituent group A represents the group consisting of halogen atoms, C1-C6 alkyl groups, and so forth.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: January 6, 2015
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Makoto Mori, Kunihiko Fujii, Masaharu Inui, Takayuki Baba, Yukari Onishi, Atsushi Aoyagi
  • Publication number: 20140080808
    Abstract: The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11?-hydroxysteroid dehydrogenase type 1: General formula (I) wherein R1 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from substituent group A or a heterocyclic group that may be substituted with 1 to 4 group(s) independently selected from substituent group A; R2 independently represents a halogen atom or a C1-C6 alkyl group; n represents an integer of 0 to 2; and substituent group A represents the group consisting of halogen atoms, C1-C6 alkyl groups, and so forth.
    Type: Application
    Filed: October 18, 2013
    Publication date: March 20, 2014
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Makoto Mori, Kunihiko Fujii, Masaharu Inui, Takayuki Baba, Yukari Onishi, Atsushi Aoyagi
  • Patent number: 8168420
    Abstract: Disclosed are: a novel microorganism which can decompose a methylthiotriazine compound (particularly, simetryn, dimethametryn, prometryn), a chlorotriazine compound (particularly, simazine, atrazine, propazine) and a methoxytriazine compound (particularly, simeton, atraton, prometon) which have been frequently used as agrichemicals or the like; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound by using the microorganism. Specifically disclosed are: a novel bacterium Nocardioides sp. strain MTD22 which is capable of decomposing a methylthiotriazine compound, a chlorotriazine compound and a methoxytriazine compound; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound, particularly simetryn, dimethametryn, prometryn, simazine, atrazine, propazine, simeton, atraton and/or prometon, by using the microorganism.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: May 1, 2012
    Assignee: Kowa Company, Ltd.
    Inventors: Kazuhiro Takagi, Kunihiko Fujii, Naoki Harada, Akio Iwasaki
  • Publication number: 20120029026
    Abstract: The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) ?. A compound represented by the general formula (I): [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 2, 2012
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Tsuyoshi SHINOZUKA, Tomoharu TSUKADA, Kunihiko FUJII, Makoto MORI
  • Publication number: 20100068788
    Abstract: Disclosed are: a novel microorganism which can decompose a methylthiotriazine compound (particularly, simetryn, dimethametryn, prometryn), a chlorotriazine compound (particularly, simazine, atrazine, propazine) and a methoxytriazine compound (particularly, simeton, atraton, prometon) which have been frequently used as agrichemicals or the like; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound by using the microorganism. Specifically disclosed are: a novel bacterium Nocardioides sp. strain MTD22 which is capable of decomposing a methylthiotriazine compound, a chlorotriazine compound and a methoxytriazine compound; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound, particularly simetryn, dimethametryn, prometryn, simazine, atrazine, propazine, simeton, atraton and/or prometon, by using the microorganism.
    Type: Application
    Filed: November 20, 2007
    Publication date: March 18, 2010
    Applicant: KOWA COMPANY, LTD.
    Inventors: Kazuhiro Takagi, Kunihiko Fujii, Naoki Harada, Akio Iwasaki
  • Publication number: 20080125409
    Abstract: The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
    Type: Application
    Filed: October 19, 2005
    Publication date: May 29, 2008
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Naoaki Kanaya, Kunihiko Fujii
  • Patent number: 7199834
    Abstract: The vertical sync signal generator includes: a vertical sync signal separation circuit for separating a vertical sync signal of an input luminance signal and outputting the separated signal as a first vertical sync signal; an automatic frequency control circuit for generating a second vertical sync signal having a repeat frequency corresponding with an average repeat frequency of the first vertical sync signal and outputting the generated signal; a vertical sync signal phase detection circuit for detecting whether or not the first vertical sync signal has two different periods repeated alternately and outputting the detection result as a decision signal; and a selector for receiving the first and second vertical sync signals, selecting the first vertical sync signal when the decision signal indicates that the first vertical sync signal has two different periods repeated alternately and otherwise selecting the second vertical sync signal and outputting the selected signal.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: April 3, 2007
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Kunihiko Fujii, Toshihiro Miyoshi, Kazuhide Fujimoto, Manabu Yumine, Toshiya Noritake
  • Publication number: 20060189591
    Abstract: The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.
    Type: Application
    Filed: April 20, 2004
    Publication date: August 24, 2006
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Toru Okayama, Kouichi Uoto, Takashi Ishiyama, Naoaki Kanaya, Youichi Kimura, Hiroaki Ishihara, Toshiyuki Watanabe, Kunihiko Fujii
  • Publication number: 20040207756
    Abstract: The vertical sync signal generator includes: a vertical sync signal separation circuit for separating a vertical sync signal of an input luminance signal and outputting the separated signal as a first vertical sync signal; an automatic frequency control circuit for generating a second vertical sync signal having a repeat frequency corresponding with an average repeat frequency of the first vertical sync signal and outputting the generated signal; a vertical sync signal phase detection circuit for detecting whether or not the first vertical sync signal has two different periods repeated alternately and outputting the detection result as a decision signal; and a selector for receiving the first and second vertical sync signals, selecting the first vertical sync signal when the decision signal indicates that the first vertical sync signal has two different periods repeated alternately and otherwise selecting the second vertical sync signal and outputting the selected signal.
    Type: Application
    Filed: December 10, 2003
    Publication date: October 21, 2004
    Inventors: Kunihiko Fujii, Toshihiro Miyoshi, Manabu Yumine, Toshiya Noritake
  • Patent number: 6415670
    Abstract: An injection apparatus of the present invention includes a first switching valve RV1 which is selectively connected to any of a plurality of injectors 21-30 at one end sides thereof; a second switching valve RV2 which is selectively connected to any of the plurality of injectors at the other end sides thereof; a third switching valve RV4 which is connected to the second switching valve and is selectively connected to any of a plurality of columns 31-40 at one end sides thereof; and a fourth switching valve RV5 which is selectively connected to any of the plurality of columns at the other end sides thereof A sequential switching of these four switching valves can permit the sample liquids in the injectors 21-30 to be delivered in sequence into any selected column 31-40, and as such can allow the sample liquids packed in the plurality of injectors to be efficiently dispensed or analyzed by a chromatograph.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: July 9, 2002
    Assignee: Yamazen Corporation
    Inventors: Kihachiro Ohkura, Shigeo Mukai, Kunihiko Fujii
  • Patent number: 5494418
    Abstract: A pump casing made of sheet metal has an outer casing having a suction nozzle, and an inner casing housed in said outer casing and spaced therefrom. A resilient seal is disposed in a gap defined between the outer casing and an inner casing. An impeller is rotatably disposed in the inner casing with a clearance defined between a liner portion of the inner casing and the impeller. The resilient seal is effective to absorb deformations of the outer casing, such deformations of the outer casing are not transmitted to the inner casing.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: February 27, 1996
    Assignee: Ebara Corporation
    Inventors: Masayoshi Moriya, Makoto Kobayashi, Masakazu Yamamoto, Yoshio Miyake, Hiromi Sakacho, Koji Isemoto, Seigo Katsuta, Kunihiko Fujii, Kikuichi Mori
  • Patent number: 5401146
    Abstract: A pump casing made of sheet metal has an outer casing having a suction nozzle, and an inner casing housed in said outer casing and spaced therefrom. A resilient seal is disposed in a gap defined between the outer casing and an inner casing. An impeller is rotatably disposed in the inner casing with a clearance defined between a liner portion of the inner casing and the impeller. The resilient seal is effective to absorb deformations of the outer casing, such deformations of the outer casing are not transmitted to the inner casing.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: March 28, 1995
    Assignee: Ebara Corporation
    Inventors: Masayoshi Moriya, Makoto Kobayashi, Masakazu Yamamoto, Yoshio Miyake, Hiromi Sakacho, Koji Isemoto, Seigo Katsuta, Kunihiko Fujii, Kikuichi Mori
  • Patent number: 5396294
    Abstract: Different from typical signal processing which employs a feedback control, by adopting a demodulating circuit employing AFC, which is not affected by a comb filter, the response characteristic against jitter is improved and a down converted chrominance signal can be demodulated with a good accuracy. Therefore, the noise rejection effect by a comb filter is improved, the detecting accuracy of the residual phase error is also improved, and the S/N ratio of the phase is improved by combining feedforward APC compensation with a velocity error, and this results in a much improved picture quality.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: March 7, 1995
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Kunihiko Fujii, Naoshi Usuki
  • Patent number: 4392535
    Abstract: In an automatic weighing apparatus wherein a weight measurement is performed by passing a commodity on a weighing conveyor which is coupled so as to become a load of a load cell, and a label on which data based on the measured value are printed is automatically stuck to the commodity, while a print fixing label in which a print content is fixed can also be issued; the zero-point setting is automatically performed at times when the commodity does not exist on the weighing conveyor, so as to execute in a stable state a measurement having an accurate reference point.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: July 12, 1983
    Assignee: Tokyo Electric Co., Ltd.
    Inventors: Kunihiko Fujii, Yukihiro Hirosaki, Yoshihisa Nishiyama, Koichiro Sato
  • Patent number: 4386994
    Abstract: A fully automatic labeling system having a sending-in conveyor, a weighing conveyor and a sticking conveyor which have their operations controlled independently of one another. This invention controls the operations of the conyeyors so that the conveyors may be driven in only necessary states and that weighing and label sticking may be reliably and most efficiently performed even during transfer of a commodity between the conveyors. In both a print fixing operation and a two-stage print mode for a label, transportation intervals of the commodities can automatically have necessary time differences.
    Type: Grant
    Filed: February 1, 1980
    Date of Patent: June 7, 1983
    Assignee: Tokyo Electric Co., Ltd.
    Inventors: Kunihiko Fujii, Koichi Haraga, Yukihiro Hirosaki, Koichiro Sato
  • Patent number: 4363693
    Abstract: A full-auto labeling system having sending-in conveyor, a weighing conveyor and a sticking conveyor disposed in alignment, and the respective conveyors provided with sensors for detecting a commodity, so as to control an operation of a load cell with outputs of the sensors providing the basis of an improvement which consists of a load cell periodically operated even when no commodity is being transported, whereby when a measurement value becomes necessary a stable operation can be immediately performed, and that A/D conversion by the load cell is executed twice with a single start signal, a second output being taken as the measurement value, whereby the measurement value of high reliability can be obtained.
    Type: Grant
    Filed: February 1, 1980
    Date of Patent: December 14, 1982
    Assignee: Tokyo Electric Company, Ltd.
    Inventors: Kunihiko Fujii, Yoshihisa Nishiyama