Patents by Inventor Kunihiko Ikeguchi

Kunihiko Ikeguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
    Patent number: 7588757
    Abstract: Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous system of a primate. Once delivered, the genes are expressed, which then results in dopamine synthesis and amelioration in the clinical signs and symptoms of PD. The methods of the present invention can be used to deliver the three central dopamine synthesizing enzymes: tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and guanosine triphosphate cyclohydrolase I thereby enhancing dopamine biosynthesis and providing for enhanced therapeutic efficacy.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: September 15, 2009
    Assignee: Genzyme Corporation
    Inventors: Keiya Ozawa, Ken-ichi Fujimoto, Shin-ichi Muramatsu, Kunihiko Ikeguchi, Imaharu Nakano
  • Compositions and methods for treating neurodegenerative diseases
    Publication number: 20030050273
    Abstract: Compositions and methods for treating subjects with preexisting neuronal damage are disclosed. The compositions and methods use adeno-associated virus (AAV)-based gene delivery systems for delivering glial cell line-derived neutrotrophic factor (GDNF) to subjects with neurodegenerative conditions such as Parkinson's disease.
    Type: Application
    Filed: August 28, 2002
    Publication date: March 13, 2003
    Inventors: Keiya Ozawa, Shin-Ichi Muramatsu, Kunihiko Ikeguchi, Imaharu Nakano
  • Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
    Publication number: 20020172664
    Abstract: Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous system of a primate. Once delivered, the genes are expressed, which then results in dopamine synthesis and amelioration in the clinical signs and symptoms of PD. The methods of the present invention can be used to deliver the three central dopamine synthesizing enzymes: tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and guanosine triphosphate cyclohydrolase I thereby enhancing dopamine biosynthesis and providing for enhanced therapeutic efficacy.
    Type: Application
    Filed: March 13, 2002
    Publication date: November 21, 2002
    Inventors: Keiya Ozawa, Ken-Ichi Fujimoto, Shin-Ichi Muramatsu, Kunihiko Ikeguchi, Imaharu Nakano