Patents by Inventor Kunihiko Matsushita
Kunihiko Matsushita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10376474Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60 wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.Type: GrantFiled: November 8, 2016Date of Patent: August 13, 2019Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Kunihiko Matsushita, Mamoru Naruse, Kenichi Hattori
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Patent number: 10143662Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.Type: GrantFiled: May 31, 2016Date of Patent: December 4, 2018Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
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Publication number: 20170071872Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60 wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.Type: ApplicationFiled: November 8, 2016Publication date: March 16, 2017Applicant: TEIKOKU SEIYAKU CO., LTD.Inventors: Kunihiko MATSUSHITA, Mamoru NARUSE, Kenichi HATTORI
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Patent number: 9517211Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.Type: GrantFiled: January 26, 2009Date of Patent: December 13, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Kunihiko Matsushita, Mamoru Naruse, Kenichi Hattori
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Publication number: 20160271075Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.Type: ApplicationFiled: May 31, 2016Publication date: September 22, 2016Inventors: Mamoru NARUSE, Kenichi HATTORI, Kunihiko Matsushita
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Patent number: 9375422Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.Type: GrantFiled: July 21, 2010Date of Patent: June 28, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
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Patent number: 8486442Abstract: An external patch capable of stable prolonged release and transdermal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt. % of styrene/isoprene/styrene block copolymer, 20 to 70 wt. % of tackifier resin, 10 to 60 wt. % of softener and 1 to 20 wt. % of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.Type: GrantFiled: May 13, 2004Date of Patent: July 16, 2013Assignees: Teikoku Seiyaku Co. Ltd., Fuso Pharmaceutical Industries Ltd.Inventors: Kunihiko Matsushita, Kenichi Hattori, Masahiro Yamaji
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Publication number: 20120071511Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.Type: ApplicationFiled: July 21, 2010Publication date: March 22, 2012Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
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Publication number: 20100322999Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.Type: ApplicationFiled: January 26, 2009Publication date: December 23, 2010Inventors: Kunihiko Matsushita, Mamoru Naruse, Kenichi Hattori
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Publication number: 20070065493Abstract: An external patch capable of stable prolonged release and transdermal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt. % of styrene/isoprene/styrene block copolymer, 20 to 70 wt. % of tackifier resin, 10 to 60 wt. % of softener and 1 to 20 wt. % of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.Type: ApplicationFiled: May 13, 2004Publication date: March 22, 2007Applicants: TEIKOKU SEIYAKU CO. LTD., FUSO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Kunihiko Matsushita, Kenichi Hattori, Masahiro Yamaji
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Patent number: D932634Type: GrantFiled: November 5, 2019Date of Patent: October 5, 2021Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Satoshi Kawakami, Kunihiko Matsushita