Patents by Inventor Kunihiko Murata
Kunihiko Murata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9617292Abstract: The purpose of the invention is to provide a novel organometallic compound that can be utilized as a catalyst having high generality, high activity, and excellent functional group selectivity. The invention pertains to a novel organometallic compound represented by general formula (1) that catalyzes a reductive amination reaction.Type: GrantFiled: April 22, 2014Date of Patent: April 11, 2017Assignee: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Toshihide Takemoto, Kouichi Tanaka, Kunihiko Murata
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Publication number: 20160060282Abstract: The purpose of the invention is to provide a novel organometallic compound that can be utilized as a catalyst having high generality, high activity, and excellent functional group selectivity. The invention pertains to a novel organometallic compound represented by general formula (1) that catalyzes a reductive amination reaction.Type: ApplicationFiled: April 22, 2014Publication date: March 3, 2016Applicant: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Toshihide Takemoto, Kouichi Tanaka, Kunihiko Murata
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Patent number: 9211533Abstract: [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups. [Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.Type: GrantFiled: June 6, 2013Date of Patent: December 15, 2015Assignee: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Junichi Hori, Kunihiko Murata
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Patent number: 9174906Abstract: Methods are provided for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. For example, aromatic ketones and heteroaromatic ketones are reacted with hydrogen and/or a hydrogen donating compound in the presence of the ruthenium complex.Type: GrantFiled: July 25, 2014Date of Patent: November 3, 2015Assignees: KANTO KAGAKU KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Takeaki Katayama, Kunihiko Tsutsumi, Kunihiko Murata, Takeshi Ohkuma, Noriyoshi Arai
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Patent number: 9162934Abstract: The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.Type: GrantFiled: May 10, 2011Date of Patent: October 20, 2015Assignee: Kanto Kagaku Kabushiki KaishaInventors: Taito Hatakeyama, Kunihiko Murata, Kunihiko Tsutsumi, Noriyuki Utsumi
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Publication number: 20150031920Abstract: [Object] The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound.Type: ApplicationFiled: July 25, 2014Publication date: January 29, 2015Inventors: TAKEAKI KATAYAMA, KUNIHIKO TSUTSUMI, KUNIHIKO MURATA, TAKESHI OHKUMA, NORIYOSHI ARAI
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Publication number: 20130338359Abstract: [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups. [Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.Type: ApplicationFiled: June 6, 2013Publication date: December 19, 2013Inventors: Masahito Watanabe, Junichi Hori, Kunihiko Murata
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Patent number: 8558033Abstract: The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor. The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at ? position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at ? position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.Type: GrantFiled: June 28, 2011Date of Patent: October 15, 2013Assignee: Kanto Kagaku Kabushiki KaishaInventors: Takeaki Katayama, Toshihide Takemoto, Kunihiko Murata
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Patent number: 8481735Abstract: [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups. [Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.Type: GrantFiled: March 12, 2010Date of Patent: July 9, 2013Assignee: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Junichi Hori, Kunihiko Murata
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Patent number: 8212037Abstract: A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.Type: GrantFiled: March 30, 2005Date of Patent: July 3, 2012Assignees: Kanto Kagaku Kabushiki Kaisha, Nagoya Industrial Science Research InstituteInventors: Ryoji Noyori, Takeshi Okuma, Kunihiko Tsutsumi, Noriyuki Utsumi, Kunihiko Murata, Takeaki Katayama
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Publication number: 20120065426Abstract: The present invention aims to provide a practical process for preparing amine compounds through a generalized highly-diastereoselective reductive amination reaction.Type: ApplicationFiled: September 14, 2011Publication date: March 15, 2012Applicant: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Kouichi Tanaka, Takashi Miki, Kunihiko Murata
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Publication number: 20110319671Abstract: The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor. The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at ? position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at ? position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.Type: ApplicationFiled: June 28, 2011Publication date: December 29, 2011Applicant: Kanto Kagaku Kabushiki KaishaInventors: Takeaki Katayama, Toshihide Takemoto, Kunihiko Murata
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Publication number: 20110282077Abstract: The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.Type: ApplicationFiled: May 10, 2011Publication date: November 17, 2011Applicant: Kanto Kagaku Kabushiki KaishaInventors: Taito Hatakeyama, Kunihiko Murata, Kunihiko Tsutsumi, Noriyuki Utsumi
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Publication number: 20100234596Abstract: [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups. [Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.Type: ApplicationFiled: March 12, 2010Publication date: September 16, 2010Applicant: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Junichi Hori, Kunihiko Murata
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Patent number: 7687630Abstract: The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen in the presence of a certain metal complex.Type: GrantFiled: September 28, 2007Date of Patent: March 30, 2010Assignee: Kanto Kagaku Kabushiki KaishaInventors: Takeaki Katayama, Kunihiko Murata
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Publication number: 20100069683Abstract: The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst. The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a ? bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.Type: ApplicationFiled: August 28, 2009Publication date: March 18, 2010Applicant: Kanto Kagaku Kabushiki KaishaInventors: Takashi Miki, Junichi Hori, Toshihide Takemoto, Noriyuki Utsumi, Takeaki Katayama, Masahito Watanabe, Kunihiko Murata
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Patent number: 7619125Abstract: A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)XjLk (where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that Xj has a valence of ?2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.Type: GrantFiled: March 30, 2005Date of Patent: November 17, 2009Assignees: Kanto Kagaku Kabushiki Kaisha, Nagoya Industrial Science Research InstituteInventors: Junichi Hori, Kunihiko Murata, Nobuhito Kurono, Takeshi Ohkuma, Ryoji Noyori
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Patent number: 7601667Abstract: A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol.Type: GrantFiled: March 10, 2006Date of Patent: October 13, 2009Assignees: Kanto Kagaku Kabushiki Kaisha, Nagoya Industrial Science Research InstituteInventors: Noriyuki Utsumi, Kunihiko Murata, Kunihiko Tsutsumi, Takeaki Katayama, Masahito Watanabe, Takeshi Ohkuma, Ryoji Noyori
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Publication number: 20090216019Abstract: A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.Type: ApplicationFiled: March 30, 2005Publication date: August 27, 2009Inventors: Ryoji Noyori, Takeshi Okuma, Kunihiko Tsutsumi, Nariyuki Utsumi, Kunihiko Murata, Takeaki Katayama
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Publication number: 20090062573Abstract: The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst. The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a ? bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.Type: ApplicationFiled: July 18, 2008Publication date: March 5, 2009Applicant: Kanto Kagaku Kabushiki KaishaInventors: Takashi Miki, Junichi Hori, Toshihide Takemoto, Noriyuki Utsumi, Takeaki Katayama, Masahito Watanabe, Kunihiko Murata