Abstract: The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-?-amino acid of formula (I): (in the formula (I), R1 is a hydrocarbon group) is reacted with an aldehyde of formula (II): (in the formula (II), R2 is a hydrocarbon) to produce an L-serine derivative of formula (III).

Abstract: A method for producing ?-hydroxy amino acid and its optically-active isomer is provided. The ?-hydroxy amino acid is produced by reacting a predetermined D-?-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.

Abstract: A method for producing ?-hydroxy amino acid and its optically-active isomer is provided. The ?-hydroxy amino acid is produced by reacting a predetermined D-?-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.

Abstract: A shield conductor has a metal pipe and wires accommodated in the metal pipe. The metal pipe is stainless steel, and the stainless steel pipe is provided with a resin layer containing a magnetic material.

Abstract: A distributive conductor electromagnetically shields and protects an insulated wire 10 by inserting it into a pipe 20. Heat generated in the insulated wire 10 is absorbed into a low heat-reflective layer 21 of lower heat reflectivity, transferred to the pipe 20, and then dissipated from an outer circumferential wall of the pipe 20 to atmosphere.

Abstract: A method for producing ?-hydroxy amino acid and its optically-active isomer is provided. The ?-hydroxy amino acid is produced by reacting a predetermined D-?-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.

Abstract: 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.

Abstract: The present invention provides genes that encode the N-acetyl-(R,S)-?-amino acid acylases. The N-acetyl-(R,S)-?-amino acid acylases were isolated and purified from bacterial cells and the nucleotide sequences were determined. A host, such as Escherichia coli, was used to construct a high-expression system for these genes. The N-acetyl-(R)-?-amino acid acylase produced by Burkholderia sp. AJ110349 (FERM BP-10366) includes, for example, the protein having the amino acid sequence shown in SEQ. ID. NO. 8. The gene encoding this enzyme includes, for example, the DNA having the nucleotide sequence as shown in SEQ. ID. NO. 7. The N-acetyl-(S)-?-amino acid acylase produced by Burkholderia sp. AJ110349 (FERM BP-10366) includes, for example, the protein having the amino acid sequence shown in SEQ. ID. NO. 10. The gene encoding this enzyme includes, for example, the DNA having the nucleotide sequence shown inshown in SEQ. ID. NO. 9. The N-acetyl-(R)-?-amino acid acylase produced by Variovorax sp.

Abstract: The present invention provides a display device which can obviate the occurrence of a leak current in a thin film transistor. In a display device including a substrate, and gate signal lines, an insulation film, semiconductor layers and conductor layers which are sequentially stacked on the substrate, the conductor layer forms at least a drain electrode which is connected to a drain signal line and a source electrode which is connected to a pixel electrode, and the semiconductor layer is formed in a pattern in which the semiconductor layer has a protruding portion which protrudes outwardly from the conductor layer at a portion thereof except for a distal end of the drain electrode as viewed in a plan view.

Abstract: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted ?-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.

Abstract: A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:4.

Abstract: The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.

Abstract: The present invention provides a method for manufacturing a display device which can reliably form electrodes in a thin film transistor.

Abstract: A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in efficiently producing the (2R, 4R)-monatin in an amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:2.

Abstract: Since it is configured such that the gap between the pipe 20 and the electric wire 10 in the pipe 20 is filled with a filler 30 having a heat conductivity higher than that of air, the heat generated in the electric wire 10 is transferred to the filler 30, then from the filler 30 to the pipe 20, and is discharged from the outer periphery of the pipe 20 to the outside air. Since the filler 30 has a heat conductivity higher than that of air, the performance in discharging the heat generated in the electric wire 10 is superior compared with a case in which the filler 30 is not charged. Thus, heat dissipation in the shield conductor using a pipe is improved.

Abstract: The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).

Abstract: An active matrix type display device includes inter-pad short-circuiting lines which are connected with signal lines, terminal portions which transmit signals from an IC chip to the signal lines, and a plurality of short-circuiting lines which are arranged outside the terminal portions and inside an end surface of a substrate and are connected with a plurality of inter-pad short-circuiting lines, wherein cut regions of the inter-pad short-circuiting lines are arranged outside the terminal portions and inside the short-circuiting lines. Since repair lines and signal-line lead line do not cross each other, it is possible to perform the highly reliable repair in respective manufacturing steps.

Abstract: The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl ?-amino acid to selectively produce an R-?-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis activity on an N-acetyl ?-amino acid to selectively produce an S-?-amino acid and an acylase having an asymmetric hydrolysis activity of an N-acetyl ?-amino acid to selectively produce an R-?-amino acid, and a process for the selective production of an S-, or R-?-amino acid using the above strains.

Abstract: 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.

Abstract: The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2.