Patents by Inventor Kunihiro Ninomiya
Kunihiro Ninomiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5861411Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: April 10, 1996Date of Patent: January 19, 1999Assignee: Mitsubishi Chemical CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Saito, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 5536728Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: December 8, 1994Date of Patent: July 16, 1996Assignee: Mitsubishi Chemical CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Saito, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 5397785Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: September 2, 1993Date of Patent: March 14, 1995Assignee: Mitsubishi Kasei CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Sato, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 4985430Abstract: There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or pharmaceutically acceptable acid addition salt thereof and a memory enhancing agent containing the same as an active ingredient.Type: GrantFiled: December 2, 1988Date of Patent: January 15, 1991Assignee: Mitsubishi Kasei CorporationInventors: Shuji Morita, Ken-Ichi Saito, Kunihiro Ninomiya, Akihiro Tobe, Issei Nitta, Mamoru Sugano
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Patent number: 4977151Abstract: Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piperazino group, imidazolyl group 4-alkyl substituted imidazolyl group or substituted amino group,R.sup.2 represents a hydrogen atom or an alkoxy group having 1 to 3 carbon atoms, andR.sup.3 represents a piperidino group, piperazino group or 4-alkyl substituted piperazino group, orR.sup.1 and R.sup.2 together with a phenyl group to which they are attached may form a phenothiazin-2-yl group, N-acetyl-phenothiazin-2-yl group, thianthren-2-yl group, dibenzothiophen-3-yl group, dibenzofuran-3-yl group or a group of the formula: ##STR2## wherein R.sup.Type: GrantFiled: March 29, 1990Date of Patent: December 11, 1990Assignee: Mitsubishi Kasei CorporationInventors: Shinichiro Fujimori, Satoshi Yamazaki, Mamoru Sugano, Makoto Kawamura, Kunihiro Ninomiya, Akihiro Tobe, Issei Nitta
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Patent number: 4933344Abstract: Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piparazino group, imidazolyl group, 4-alkyl substituted imidazolyl group or substituted amino group,R.sup.2 represents a hydrogen atom or an alkoxy group having 1 to 3 carbon atoms, andR.sup.3 represents a piperidino group, piperazino group or 4-alkyl substituted piperazino group, orR.sup.1 and R.sup.2 together with a phenyl group to which they are attached may form a phenothiazin-2-yl group, N-acetyl-phenothiazin-2-yl group, thianthren-2-yl group, dibenzothiophen-3-yl group, dibenzofuran-3-yl group or a group of the formula: ##STR2## wherein R.sup.Type: GrantFiled: August 31, 1988Date of Patent: June 12, 1990Assignee: Mitsubishi Kasei CorporationInventors: Shinichiro Fujimori, Satoshi Yamazaki, Mamoru Sugano, Makoto Kawamura, Kunihiro Ninomiya, Akihiro Tobe, Issei Nitta
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Patent number: 4883802Abstract: A novel 4-piperidinecarboxamide derivatives represented by the general formula (I): ##STR1## wherein each R.sup.1 and R.sup.2 represents a hydrogen atom, or R.sup.1 together with R.sup.2 represents a cyclopentanespiro or cyclohexanespiro group; R.sup.3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group or an indolylalkyl group; and n is an integer of 1 or 2;is disclosed herein. The novel compound is useful as the agent for improving the impaired brain fuction.Type: GrantFiled: September 9, 1988Date of Patent: November 28, 1989Assignee: Mitsubishi Kasei CorporationInventors: Kunihiro Ninomiya, Ken-Ichi Saito, Shuji Morita, Akihiro Tobe, Issei Nitta
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Patent number: 4880819Abstract: Novel 4-aminopyridine derivatives represented by the general formula (I): ##STR1## wherein A and B independently represent ##STR2## and n is an integer of 1 or 2; as well as their pharmaceutically acceptable acid addition salts are disclosed herein. The novel compounds are useful as the agent for improving impaired brain function.Type: GrantFiled: September 9, 1988Date of Patent: November 14, 1989Assignee: Mitsubishi Kasei CorporationInventors: Kunihiro Ninomiya, Ken-Ichi Saito, Shuji Morita, Akihiro Tobe, Issei Nitta
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Patent number: 4695568Abstract: This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): ##STR1## or salts thereof; wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R.sup.1 and R.sup.2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R.sup.3 and R.sup.4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R.sup.5 represents a member selected from(1) hydrogen or alkyl having 1 to 6 carbon atoms,(2) ##STR2## in which m is an integer of from 1 to 3 and X represents halogen, or (3) ##STR3## in which R.sup.6 represents alkyl group having 1 to 6 carbon atoms; Ar represents substituted or unsubstituted phenyl, or 2- or 3-thienyl group; and n is 2 or 3. The derivatives of the invention can be used in the treatment of the various depression disease or the higher dysfunction of the brain.Type: GrantFiled: December 24, 1984Date of Patent: September 22, 1987Assignee: Mitsubishi Chemical Industries LimitedInventors: Kunihiro Ninomiya, Issei Nitta, Akihiro Tobe, Mitsuo Egawa, Ryoji Kikumoto
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Patent number: 4599419Abstract: (3-Aminopropoxy)bibenzyl derivatives are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.Type: GrantFiled: July 9, 1984Date of Patent: July 8, 1986Assignee: Mitsubishi Chemical Industries, Inc.Inventors: Ryoji Kikumoto, Harukazu Fukami, Hiroto Hara, Kunihiro Ninomiya, Mamoru Sugano
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Patent number: 4485258Abstract: (3-Aminopropoxy)bibenzyl derivatives are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.Type: GrantFiled: July 29, 1982Date of Patent: November 27, 1984Assignee: Mitsubishi Chemical Industries LimitedInventors: Ryoji Kikumoto, Harukazu Fukami, Hiroto Hara, Kunihiro Ninomiya, Mamoru Sugano
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Patent number: 4323568Abstract: (Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.Type: GrantFiled: December 6, 1979Date of Patent: April 6, 1982Assignee: Mitsubishi Chemical Industries LimitedInventors: Kyoji Kikumoto, Kunihiro Ninomiya, Harukazu Fukami, Hiroto Hara
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Patent number: 4310534Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.Type: GrantFiled: July 30, 1980Date of Patent: January 12, 1982Assignee: Mitsubishi Chemical Industries LimitedInventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Mitsuo Egawa, Kunihiro Ninomiya
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Patent number: 4284637Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.Type: GrantFiled: October 1, 1979Date of Patent: August 18, 1981Assignee: Mitsubishi Chemical Ind., LimitedInventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Kunihiro Ninomiya, Mitsuo Egawa
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Patent number: 4220603Abstract: (Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.Type: GrantFiled: September 19, 1978Date of Patent: September 2, 1980Assignee: Mitsubishi Chemical Industries, LimitedInventors: Ryoji Kikumoto, Kunihiro Ninomiya, Harukazu Fukami, Hiroto Hara
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Patent number: 4217366Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.Type: GrantFiled: February 14, 1979Date of Patent: August 12, 1980Assignee: Mitsubishi Chemical Industries, Ltd.Inventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Kunihiro Ninomiya, Mitsuo Egawa
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Patent number: 4144254Abstract: 19-Norethisterone or 19-norandrost-4-ene-3,17-dione is purified by passing its solution in an aromatic hydrocarbon, an alkyl halide or an ester of acetic acid through a column packed with basic alumina and then crystallizing it.Type: GrantFiled: November 29, 1977Date of Patent: March 13, 1979Assignee: Mitsubishi Chemical Industries LimitedInventors: Haruo Imai, Tadashi Oohama, Ryozo Yamaguchi, Kunihiro Ninomiya