Abstract: A foreign substance removing device includes a tubular member and a retriever configured to be expandable to and contractible from a predetermined shape. The retriever includes main wires disposed to be centered around a tube axis of the tubular member, and sub wires each connecting adjacent ones of the main wires to each other. Each of the main wires is configured to curve when the retriever is expanded such that a space having a predetermined size is provided by the main wires. Each of the sub wires is configured to be foldable at at least one point between the adjacent ones of the main wires. When the retriever is expanded, the folding points of the sub wires are positioned inside the space such that the sub wires do not protrude out of the main wires.

Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

Abstract: In a walking assist chair, a lifting seat is movable between a first position in which the lifting seat is arranged to form a part of a seat of a wheelchair and a second position that is away from the ground compared to the first position. A receding seat is movable between a third position in which the receding seat is arranged adjacent to the lifting seat arranged in the first position so as to form a part of the seat of the wheelchair and a fourth position in which the receding seat is separated from the lifting seat in the second position. The walking assist chair functions as a wheelchair with a seat on which a user can sit. The walking assist chair functions in a second form as a walking assist apparatus that can support the user in a standing posture.

Abstract: A foreign substance removing device includes a tubular member and a retriever configured to be expandable to and contractible from a predetermined shape. The retriever includes main wires disposed to be centered around a tube axis of the tubular member, and sub wires each connecting adjacent ones of the main wires to each other. Each of the main wires is configured to curve when the retriever is expanded such that a space having a predetermined size is provided by the main wires. Each of the sub wires is configured to be foldable at at least one point between the adjacent ones of the main wires. When the retriever is expanded, the folding points of the sub wires are positioned inside the space such that the sub wires do not protrude out of the main wires.

Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

Abstract: An anastomosis device 3 includes a corrugated circumference section (20;120;120?), a top-side slender member (10A-1;110A-1), and a bottom-side slender member (10B-1;110B-12). The top-side slender member (10A-1;110A-1) is connected to one top section (20A-1;30A-1;120A-1) of the corrugated circumference section (20; 120;120?). The bottom-side slender member (10B-1;110B-12) is connected to one (20B-1;30B-1;120B-12) at the corrugated circumference section (20;120;120?).

Abstract: A method of increasing the biomass of a plant that includes planting a plant having plant cells carrying an exogenous gene that encodes a thermophilic restriction enzyme that promotes double-stranded DNA breakage, and growing the plant at least until after true leaf development, wherein the mean biomass of plants having the plant cells carrying the exogenous gene that are grown at least until after true leaf development is increased in comparison with the mean biomass of plants of the same species that do not carry the exogenous gene that are grown for the same amount of time.

Abstract: The present invention provides a method for obtaining diverse novel genes by inducing somatic cell homologous recombination at genetic loci in somatic cells. By controlling transcription activity of a gene that exists at a genetic locus in a eukaryotic organism cell wherein DNA homologous recombination is occurring at an arbitrary genetic locus, somatic cell homologous recombination is induced between said gene and a gene having a DNA sequence similar to said gene that exists in a region upstream of a transcription promoter, whereby it is possible to obtain diverse novel genes having a plurality of genetic information.

Abstract: It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact with magnetic beads, on the surface of each of which a photoreactive compound has bound; extending the magnetic beads together with the compound on a support; and applying light to the magnetic beads to form a covalent bond between the photoreactive compound and the compound.

Abstract: According to the present invention, a technique of increasing the frequency of genetic recombination in genomic DNA of a plant is established. Such technique comprises: introducing a restriction enzyme gene that can be expressed in a target plant cell into the plant cell and causing the restriction enzyme gene to be transiently expressed so as to induce genetic recombination of genomic DNA; or introducing a promoter and a restriction enzyme gene using the Agrobacterium method so as to induce genetic recombination of genomic DNA.

Abstract: It is an object of the present invention to increase the biomass quantity of plants by causing an exogenous gene to be carried in plant cells. An exogenous gene that promotes double-stranded DNA breakage is introduced into the cells of a plant, and the plant is grown.

Abstract: In order to identify a factor demonstrating a repellent effect on axon extension of a neuron, lysophosphatidylglucoside (LPG) has been found to have an activity as a chemorepellent effect on axon guidance of a DRG sensory neuron specific to a neuron expressing TrkA, an NGF receptor. In addition, it has been found out that suppressing the function of LPG makes it possible to suppress a repellent effect of LPG on axon extension of a neuron expressing TrkA. A molecule capable of suppressing the function of LPG can be a composition promoting repairing of a neural circuit in neuronal damages and the like.

Abstract: In order to identify a factor demonstrating a repellent effect on axon extension of a neuron, lysophosphatidylglucoside (LPG) has been found to have an activity as a chemorepellent effect on axon guidance of a DRG sensory neuron specific to a neuron expressing TrkA, an NGF receptor. In addition, it has been found out that suppressing the function of LPG makes it possible to suppress a repellent effect of LPG on axon extension of a neuron expressing TrkA. A molecule capable of suppressing the function of LPG can be a composition promoting repairing of a neural circuit in neuronal damages and the like.

Abstract: The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By putting immunocytes in which DNA homologous recombination is occurring at an antibody locus (for example, DT40 cells and the like) into contact and the like with histone acetylase inhibitor and the like (for example, trichostatin A and the like), thereby relaxing the chromatin structure at said antibody locus, somatic homologous recombination at an antibody locus is enhanced, and the production of diverse antibody molecules is made possible. The production of antibodies that bind specifically to antigens from cell populations in which the antibody molecules have been diversified by the enhancement of somatic homologous recombination is made possible by using an appropriate selection method (for example, beads coated with antigen and the like).

Abstract: A power line communication system which enables high quality communication utilizing a pair of power lines connected to a vehicle mounted battery, has a pair of communication lines connected to a pair of power lines, respectively, to communicate a high frequency signal of 1 MHz or more. This system has a balance filter which is interposed between each of the communication lines and a vehicle mounted communication apparatus, the filter, a circuit configuration of which is formed in balance type. The communication system also has a pair of electrically balanced lines which are connected between the balance filter and each of the communication apparatuses and are power-fed from the battery, for performing communication between the communication apparatuses.

Abstract: According to the present invention, a technique of increasing the frequency of genetic recombination in genomic DNA of a plant is established. Such technique comprises: introducing a restriction enzyme gene that can be expressed in a target plant cell into the plant cell and causing the restriction enzyme gene to be transiently expressed so as to induce genetic recombination of genomic DNA; or introducing a promoter and a restriction enzyme gene using the Agrobacterium method so as to induce genetic recombination of genomic DNA.

Abstract: The present invention relates to a method for increasing genetic recombination frequency in a genomic DNA and a method for inducing genome rearrangement. Specifically, according to the present invention there are provided: the method for increasing genetic recombination frequency in a cell in which genetic recombination takes place at any sites in the genome, comprising causing a restriction enzyme to be expressed in the cell, inducing transient activation of the restriction enzyme, and then introducing 2 or more double strand cleavages into any genomic DNA of the cell, so as to increase the genetic recombination frequency; the method for inducing genome rearrangement through the use of the above method; and cells each prepared through the use of the above 2 methods.

Abstract: The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By putting immunocytes in which DNA homologous recombination is occurring at an antibody locus (for example, DT40 cells and the like) into contact and the like with histone acetylase inhibitor and the like (for example, trichostatin A and the like), thereby relaxing the chromatin structure at said antibody locus, somatic homologous recombination at an antibody locus is enhanced, and the production of diverse antibody molecules is made possible.

Abstract: It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact with magnetic beads, on the surface of each of which a photoreactive compound has bound; extending the magnetic beads together with the compound on a support; and applying light to the magnetic beads to form a covalent bond between the photoreactive compound and the compound.

Abstract: The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By putting immunocytes in which DNA homologous recombination is occurring at an antibody locus (for example, DT40 cells and the like) into contact and the like with histone acetylase inhibitor and the like (for example, trichostatin A and the like), thereby relaxing the chromatin structure at said antibody locus, somatic homologous recombination at an antibody locus is enhanced, and the production of diverse antibody molecules is made possible. The production of antibodies that bind specifically to antigens from cell populations in which the antibody molecules have been diversified by the enhancement of somatic homologous recombination is made possible by using an appropriate selection method (for example, beads coated with antigen and the like).