Patents by Inventor Kunikazu Hiraga

Kunikazu Hiraga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5391558
    Abstract: A composition for accelerating healing of a wound is disclosed, comprising as an active ingredient a compound represented by formula (I): ##STR1## wherein R represents a hydrogen atom, a phenyl group or a phenyl group substituted with a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a hydroxyl group or a C.sub.1 -C.sub.6 alkoxy group; and X represents a 1-imidazolyl group or a 1,2,4-triazol-1-yl group.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: February 21, 1995
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Akira Seo, Kunikazu Hiraga, Hiroyasu Koga, Yoshimi Niwano
  • Patent number: 5098928
    Abstract: The ketenedithioacetal derivatives of formula (I) have a potent hypolipidemic and anti-arteriosclerotic effect and are useful for prophylaxis and treatment of arteriosclerosis or hyperlipidemia.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: March 24, 1992
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Masashi Nagamine, Kunikazu Hiraga, Atsushi Sakai, Matazaemon Uchida
  • Patent number: 5045562
    Abstract: 1,3,5-trithiane derivatives represented by the formula (I) ##STR1## wherein the substituents are defined herein, are disclosed. The trithiane derivatives and their compositions are useful as anti-arteriosclerotic or anti-hyperlipemic agents.
    Type: Grant
    Filed: October 17, 1988
    Date of Patent: September 3, 1991
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Masashi Nagamine, Kunikazu Hiraga, Atsushi Sakai, Matazaemon Uchida
  • Patent number: 5041440
    Abstract: Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C.sub.2 -C.sub.7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy; Y represents C.sub.2 -C.sub.7 alkylcarbonyl group, C.sub.2 -C.sub.7 alkoxycarbonyl group or cyano group; and R represents di (C.sub.1 -C.sub.4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: August 20, 1991
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Shuhei Kubota, Kunikazu Hiraga, Keisuke Nakayama, Matazaemon Uchida
  • Patent number: 4863925
    Abstract: A cyclohexanedione derivative represented by the general formula (I); ##STR1## wherein R.sup.1, R.sup.4 and R.sup.7 represent independently hydrogen atom or C.sub.1 -C.sub.8 alkyl group, R.sup.2 represents hydrogen atom; C.sub.1 -C.sub.8 alkyl group; C.sub.2 -C.sub.6 alkenyl group; C.sub.3 -C.sub.8 cycloalkyl group; C.sub.2 -C.sub.7 alkoxycarbonyl group; C.sub.1 -C.sub.6 alkylthio C.sub.1 -C.sub.6 alkyl group; a phenyl group; a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 haloalkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.6 alkylthio group, C.sub.3 -C.sub.8 cycloalkoxy group, a benzyloxy group and a benzyloxy group substituted with C.sub.1 -C.sub.6 alkoxy group; naphthyl group or a heterocyclic group, R.sup.3 represents hydrogen atom, C.sub.1 -C.sub.8 alkyl group or C.sub.2 -C.sub.7 alkoxycarbonyl group, and R.sup.5 and R.sup.6, which may be the same or different, represent hydrogen atom, C.sub.1 -C.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: September 5, 1989
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Shuhei Kubota, Kunikazu Hiraga, Keisuke Nakayama, Matazaemon Uchida
  • Patent number: 4835153
    Abstract: This invention relates to a malonic acid derivative represented by the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represents hydrogen atom; C.sub.1 -C.sub.12 alkyl group; C.sub.1 -C.sub.8 alkyl group substituted with C.sub.1 -C.sub.5 alkoxy group, a tetrahydrofuryl group, a phenyl group or a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atoms, C.sub.1 -C.sub.5 alkyl groups and C.sub.1 -C.sub.5 alkoxy groups; or C.sub.2 -C.sub.6 alkenyl group; R.sup.3 and R.sup.4, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.8 alkoxyalkyl group, benzoyl group, C.sub.2 -C.sub.8 alkylcarbonyl group, C.sub.2 -C.sub.8 alkoxycarbonyl group, C.sub.1 -C.sub.4 alkylsulfonyl group or aralkyl group including benzyl group, and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, represent hydrogen atom or C.sub.1 -C.sub.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: May 30, 1989
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Shuhei Kabota, Kunikazu Hiraga, Keisuke Nakayama, Matazaemon Uchida, Kuniaki Taninaka
  • Patent number: 4816475
    Abstract: An anti-arteriosclerotic or anti-hyperlipemic 1,3,5-trithiane derivative according to the formula (I): ##STR1## a pharmaceutical composition containing the same, and a process for producing the same.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: March 28, 1989
    Assignee: Nihon Nohyaku Co. Ltd.
    Inventors: Masashi Nagamine, Kunikazu Hiraga, Atsushi Sakai, Matazaemon Uchida
  • Patent number: 4334914
    Abstract: Novel benzoate derivatives having a powerful herbicidal effect on various weeds grown in paddy fields, upland fields, and other places have been found out, which are represented by the formula ##STR1## wherein X is --SR, --O--CH.sub.2 CH.sub.2 O).sub.n R, --OCH.sub.2 CH.sub.2 SR, ##STR2## herein R being lower alkyl and n being an integer of 1 to 3.
    Type: Grant
    Filed: February 12, 1981
    Date of Patent: June 15, 1982
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Kunikazu Hiraga, Katsumasa Okawa, Kenichi Ikeda, Masanori Hikawa
  • Patent number: 4334915
    Abstract: A phenoxyphthalate of the formula ##STR1## wherein X represents chlorine atom or trifluoromethyl group and R and R' represent methyl or ethyl group, is novel and has a strong herbicidal activity.
    Type: Grant
    Filed: February 22, 1980
    Date of Patent: June 15, 1982
    Assignee: Nihon Nohyaku Co. Ltd.
    Inventors: Kunikazu Hiraga, Masakazu Shibayama, Katsumasa Ohkawa, Tatsuo Harada
  • Patent number: 4226616
    Abstract: A diphenyl ether represented by the general formula (I), ##STR1## wherein R is a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxyethyl group, the alkoxy substituent of which having 1 to 4 carbon atoms, or a lower alkoxyethoxyethyl group, the alkoxy substituent of which having 1 to 4 carbon atoms is capable of controlling annual and perennial weeds.
    Type: Grant
    Filed: January 25, 1978
    Date of Patent: October 7, 1980
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Kunikazu Hiraga, Shoichi Shibayama, Isao Yanai, Tatsuo Harada
  • Patent number: 4157256
    Abstract: N-(p-trifluoromethoxyphenyl)-3,4,5,6-tetrahydrophthalimide and N-(p-trifluoromethylthiophenyl)-3,4,5,6-tetrahydrophthalimide are capable of controlling annual and perennial weeds with high selectivity.
    Type: Grant
    Filed: January 25, 1978
    Date of Patent: June 5, 1979
    Assignee: Nihon Nohyaku Co. Ltd.
    Inventors: Kunikazu Hiraga, Shoichi Shibayama, Isao Yanai, Tatsuo Harada