Patents by Inventor Kunikazu Totsukawa

Kunikazu Totsukawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances
    Patent number: 4169140
    Abstract: A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomyces toyocaensis SF-1771, in a liquid culture medium under aerobic conditions. This antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing antibiotic which shows antibacterial activity against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a toxicity lower than SF-1771 substance.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: September 25, 1979
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazunori Ohba, Takashi Shomura, Hiroshi Watanabe, Kunikazu Totsukawa, Michio Kojima, Shoji Omoto, Takashi Tsuruoka, Shigeharu Inoue, Taro Niida