Abstract: A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.

Abstract: A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.

Abstract: Provided is a method for producing a pseudoislet, which method comprises: seeding 1,500 to 5,000 pluripotent stem cells in a cell culture well to prepare an aggregate of said pluripotent stem cells, said aggregate having a predetermined size; and culturing said aggregate in said cell culture well in a nonadherent state, to allow differentiation into cells including pancreatic islet progenitor cells and/or pancreatic islet cells.

Abstract: A cell culture device comprising: a channel having an inlet end for the introduction of a liquid and a bottom surface, wherein said channel is configured for the flow through of said liquid; and a plurality of recesses for containing cells, which are formed on said bottom surface of said channel; wherein said plurality of recesses are closely arranged on said bottom surface of said channel.

Abstract: A method of forming a transplant site, the method comprising a process of contacting SEK-1005 (Ser,3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) with a body tissue.

Abstract: The present invention provides a production method of a novel reprogrammed stem cell, including (1) introducing a reprogramming gene into a somatic cell and (2) selecting a cell wherein the exogenous reprogramming gene is completely free of expression suppression, and a novel reprogrammed stem cell produced by this method. The present invention further provides a production method of a pluripotent stem cell or a neural stem cell from the novel reprogrammed stem cell obtained by this method.

Abstract: An apparatus for casting an ingot includes a molten metal reservoir (51) positioned at an upper portion, a casting chamber (5) positioned at a lower portion and a partition wall (3) between the reservoir and the chamber, a spruce (7) formed in the partition wall, an opening/closing plug (8) for opening and closing the sprue and control means for controlling an opening and closing operation of the plug. The casing chamber is defined in a mold (1) that includes a lower mold member (4), a side mold member (2) and the partition wall (3) that constitutes an upper mold member. At least one of the lower mold member, side mold member and upper mold member includes a plurality of divided sections (21,22) in accordance with a shape of a cast ingot C.

Abstract: A material for plastic working is produced by the steps of using a mold having a mold cavity (16) partially defined by an end surface of a stopper (13) for closing a molten metal inlet (101), teeming molten metal (10) into the mold cavity through the inlet and cooling the molten metal to thereby attain unidirectional solidification of the molten metal. Regulation of the cooling rate enables the mean grain size to be graded in the direction from the cooled face (B surface) to the opposing face (T surface) and the added components to increase in the same direction. It is possible to obtain a material for plastic working that has a selected portion exhibiting an excellent function.

Abstract: The present invention provides a casting apparatus 10A including a mold 12 having a molten metal inlet 21 at a first end portion of a partition wall 12a, and an open/close plug 13 for opening and closing the inlet 21 of the mold 12, the plug 13 being brought into contact with or detached from an inlet-defining wall, in which molten metal 1′ is teemed into the mold 12 when the plug 13 is detached from the inlet-defining wall, and teeming of the molten metal 1′ into the mold 12 is stopped when the plug 13 is brought into contact with the inlet-defining wall, wherein a member 20 having the inlet-defining wall is separable from the mold 12, and the member 20 having the inlet-defining wall is removably provided on the mold 12.

Abstract: A material for plastic working is produced by the steps of using a mold having a mold cavity (16) partially defined by an end surface of a stopper (13) for closing a molten metal inlet (101), teeming molten metal (10) into the mold cavity through the inlet and cooling the molten metal to thereby attain unidirectional solidification of the molten metal. Regulation of the cooling rate enables the mean grain size to be graded in the direction from the cooled face (B surface) to the opposing face (T surface) and the added components to increase in the same direction. It is possible to obtain a material for plastic working that has a selected portion exhibiting an excellent function.

Abstract: A metal ingot (1) solidified through unidirectional forced-cooling from a cooling member (100) to an end surface of a stopper (13), by the cooling member, of molten metal (1′) teeming via a molten metal inlet (101) of a closable mold (12) into a mold cavity (16) is plastic-worked at percent working equl to or higher than a predetermined level to obtain a plastic-worked member. The end surface of the stopper and the cooling member partially define the mold cavity. The plastic-worked member is improved in mechanical characteristics that have heretofore been inferior on the side of the end surface of the stopper and is increased in entire strength.

Abstract: [Purpose] To provide, in relation to casting of materials to be subjected to plastic working such as cold forging, hot forging, enclosed forging, rolling, extrusion, and roll-forming of metals, including nonferrous metals, such as aluminum and magnesium (inclusive of respective alloys), and ferrous metals (i.e., iron and steel) or to direct casting of products (i.e.