Patents by Inventor Kunio Hosaka
Kunio Hosaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5675023Abstract: The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Yoshimitsu Ogawa, Mika Tomita, Hiroko Hayashi, Toshitsugu Sato, Kunio Hosaka
-
Patent number: 5627204Abstract: The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.Type: GrantFiled: June 6, 1995Date of Patent: May 6, 1997Assignee: Tsumura & CompanyInventors: Yasushi Igarashi, Takuji Yamaguchi, Yoshimitsu Ogawa, Mika Tomita, Hiroko Hayashi, Toshitsugu Sato, Kunio Hosaka
-
Patent number: 5521216Abstract: The present invention relates to a chromone derivative of formula (1): ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and independently represent a hydrogen atom or a lower alkyl group) as well as a synthetic intermediate thereof and an aldose reductase inhibitor comprising said derivative as an active ingredient. The chromone derivatives of the present invention can be easily synthesized, and are useful as aldose reductase inhibitor with an excellent inhibitory action on aldose reductase.Type: GrantFiled: May 12, 1994Date of Patent: May 28, 1996Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Kunio Hosaka
-
Patent number: 5455267Abstract: The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.Type: GrantFiled: October 12, 1994Date of Patent: October 3, 1995Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Yoshimitsu Ogawa, Mika Tomita, Hiroko Hayashi, Toshitsugu Sato, Kunio Hosaka
-
Patent number: 5264594Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.Type: GrantFiled: August 24, 1992Date of Patent: November 23, 1993Assignee: Tsumura & Co.Inventors: Masayuki Kimura, Kunio Hosaka, Shigehumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 5234951Abstract: The present invention relates to an anti-ulcer agent comprising a compound represented by the following general formula I as the effective ingredient, and a novel chalcone derivative included in the compound represented by this general formula I: ##STR1## wherein X and Y independently stand for a hydrogen atom or together form a single bond, R.sub.1 stands for a hydroxyl group, an acetoxy group, a carboxymethoxy group or a methoxycarbonylmethoxy group, R.sub.2 stands for a hydrogen atom, an isoprenyl group, isopentyl group or a propyl group, R.sub.3 stands for a hydroxyl group or a methoxy group, R.sub.4 stands for a hydrogen atom, a hydroxyl group or a methoxy group, R.sub.5 stands for a hydrogen atom, a hydroxyl group, a methoxy group or an isopentyl group, R.sub.6 stands for a hydroxyl group, a methoxy group or a carboxymethoxy group, and R.sub.7 stands for a hydrogen atom or a methoxy group.Type: GrantFiled: November 25, 1991Date of Patent: August 10, 1993Assignee: Tsumura Juntendo, Inc.Inventors: Yukio Komazawa, Shigefumi Takeda, Kunio Hosaka, Hiroshi Mitsuhashi, Toshihiko Watanabe
-
Patent number: 5227398Abstract: Hepatopathy improvers contain as an effective ingredient one or more of benzodioxole derivatives represented by the following formula: ##STR1## wherein A means a particular N- or S-containing group. Most of these benzodioxole derivatives are novel.Type: GrantFiled: November 26, 1991Date of Patent: July 13, 1993Assignee: Tsumura & Co.Inventors: Masayuki Kimura, Shouichi Nishida, Shigefumi Takeda, Kunio Hosaka
-
Patent number: 5106859Abstract: A novel thiadiazole derivative represented by the following formula I: ##STR1## wherein when n is 0, m is 0, and when n is 1, m is 0 or 1, and the preparation of this derivative and the use of this derivative as an anti-ulcer agent.Type: GrantFiled: July 30, 1990Date of Patent: April 21, 1992Assignee: Tsumura & Co.Inventors: Yoshihiro Hasegawa, Toshihiko Yanagisawa, Kunio Hosaka, Hiroshi Mitsuhashi
-
Patent number: 5106871Abstract: The present invention relates to an anti-ulcer agent comprising a compound represented by the following general formula I as the effective ingredient, and a novel chalcone derivative included in the compound represented by this general formula I: ##STR1## wherein X and Y independently stand for a hydrogen atom or together form a single bond, R.sub.1 stands for a hydroxyl group, an acetoxy group, a carboxymethoxy group or a methoxycarbonylmethoxy group, R.sub.2 stands for a hydrogen atom, an isoprenyl group, isopentyl group or a propyl group, R.sub.3 stands for hydroxyl group or a methoxy group, R.sub.4 stands for a hydrogen atom, a hydroxyl group or a methoxy group, R.sub.5 stands for a hydrogen atom, a hydroxyl group, a methoxy group or an isopentyl group, R.sub.6 stands for a hydroxyl group, a methoxy group or a carboxymethoxy group, and R.sub.7 stands for a hydrogen atom or a methoxy group.Type: GrantFiled: July 19, 1991Date of Patent: April 21, 1992Assignee: Tsumura & Co.Inventors: Yukio Komazawa, Shigefumi Takeda, Kunio Hosaka, Hiroshi Mitsuhashi, Toshihiko Watanabe
-
Patent number: 5032685Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.Type: GrantFiled: November 21, 1989Date of Patent: July 16, 1991Assignee: Tsumura Juntendo, Inc.Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4996331Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.Type: GrantFiled: April 24, 1989Date of Patent: February 26, 1991Assignee: Tsumura & Co.Inventors: Masayuki Kimura, Kunio Hosaka, Shigehumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4987240Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.Type: GrantFiled: November 21, 1989Date of Patent: January 22, 1991Assignee: Tsumura & Co.Inventors: Yoshiyuki Matsuoko, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4962211Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.Type: GrantFiled: November 21, 1989Date of Patent: October 9, 1990Assignee: Tsumura & Co.Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4925872Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.Type: GrantFiled: April 24, 1989Date of Patent: May 15, 1990Assignee: Tsumura & Co.Inventors: Masayuki Kimura, Kunio Hosaka, Shigehumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4904694Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.Type: GrantFiled: February 10, 1988Date of Patent: February 27, 1990Assignee: Tsumura & Co.Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
-
Patent number: 4849448Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.Type: GrantFiled: January 19, 1988Date of Patent: July 18, 1989Assignee: Tsumura Juntendo, Inc.Inventors: Masayuki Kimura, Kunio Hosaka, Shigehumi Takeda, Hiroshi Mitsuhashi