Patents by Inventor Kunio KOMAI
Kunio KOMAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11458102Abstract: A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.Type: GrantFiled: November 8, 2018Date of Patent: October 4, 2022Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi Sakamoto, Kunio Komai, Kenji Sakakibara, Hirokazu Banba, Kiyoshi Fukuda
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Patent number: 11433031Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.Type: GrantFiled: April 5, 2021Date of Patent: September 6, 2022Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi Sakamoto, Kunio Komai, Kenji Sakakibara, Hirokazu Banba, Kiyoshi Fukuda
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Publication number: 20210267900Abstract: The present invention relates to a pre-processing method for the purpose of formulating a drug substance having non-uniform particle sizes by a manufacturing method having excellent manufacture performance. According to the pre-processing method of the present invention, additives including at least a dispersant are blended in a drug substance having a specific particle size distribution and then the resultant mixture is deagglomerated/sized to disperse and make adhere the additives onto the surfaces of the particles of the drug substance, thereby yielding a powder having a specified particle size distribution. In this manner, a pharmaceutical preparation can be manufactured with excellent manufacture performance, manufacture efficiency, and manufacture cost by a direct compression method, a wet continuous granulation system or the like. Therefore, the pre-processing method is very useful.Type: ApplicationFiled: June 25, 2019Publication date: September 2, 2021Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi SAKAMOTO, Kunio KOMAI, Kiyoshi FUKUDA, Kensuke NAMBA, Kaori SHIMOAKA
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Publication number: 20210220283Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.Type: ApplicationFiled: April 5, 2021Publication date: July 22, 2021Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi SAKAMOTO, Kunio KOMAI, Kenji SAKAKIBARA, Hirokazu BANBA, Kiyoshi FUKUDA
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Publication number: 20210186884Abstract: A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.Type: ApplicationFiled: November 8, 2018Publication date: June 24, 2021Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi SAKAMOTO, Kunio KOMAI, Kenji SAKAKIBARA, Hirokazu BANBA, Kiyoshi FUKUDA
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Patent number: 11033501Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.Type: GrantFiled: May 9, 2017Date of Patent: June 15, 2021Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi Sakamoto, Kunio Komai, Kenji Sakakibara, Hirokazu Banba, Kiyoshi Fukuda
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Publication number: 20190142754Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.Type: ApplicationFiled: May 9, 2017Publication date: May 16, 2019Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi SAKAMOTO, Kunio KOMAI, Kenji SAKAKIBARA, Hirokazu BANBA, Kiyoshi FUKUDA