Patents by Inventor Kunio Tamura
Kunio Tamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6852867Abstract: An industrially useful process for producing benzofuran derivatives of formula (1): by formylating a compound of formula (2): (where A1 is a protective group), followed by reaction with a compound of formula (4): (where X1 is a halogen atom), then performing a cyclizing reaction and subsequently performing a reaction for hydroxyl group deprotection.Type: GrantFiled: July 19, 2001Date of Patent: February 8, 2005Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Hirohito Shimizu, Yoshiaki Kato, Masahiro Shimizu
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Patent number: 6686389Abstract: 2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.Type: GrantFiled: April 15, 2002Date of Patent: February 3, 2004Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Akira Ishikawa, Yoshiaki Kato, Kunio Tamura, Yoshiaki Takashima, Osamu Cynshi
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Publication number: 20030204100Abstract: An industrially useful process for producing benzofuran derivatives of formula (1) 1Type: ApplicationFiled: January 21, 2003Publication date: October 30, 2003Inventors: Kunio Tamura, Hirohito Shimizu, Yoshiaki Kato, Masahiro Shimizu
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Publication number: 20020156296Abstract: 2,3-Dihydrobenzofuran derivatives of general formula 1Type: ApplicationFiled: April 15, 2002Publication date: October 24, 2002Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Akira Ishikawa, Yoshiaki Kato, Kunio Tamura, Yoshiaki Takashima, Osamu Cynshi
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Patent number: 6403639Abstract: 2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 represent a hydrogen atom or an optionally substituted alkyl group, or R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or alkyl-substituted nitrogen atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.Type: GrantFiled: November 23, 1999Date of Patent: June 11, 2002Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Akira Ishikawa, Yoshiaki Kato, Kunio Tamura, Yoshiaki Takashima, Osamu Cynshi
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Patent number: 6133279Abstract: Herein disclosed are therapeutic agents for renal diseases and organ preservatives containing a compound represented by the general formula (1): ##STR1## wherein X represents an oxygen atom or a group represented by the general formula (2): ##STR2## where n represents an integer from 0 to 2, R.sub.1 represents a hydrogen atom or an acyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group or a lower alkenyl group, R.sub.3 represents a lower alkyl group, R.sub.4, R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or an optionally substituted alkyl group, and R.sub.6 further represents a formyl, carboxyl, lower alkoxycarbonyl or optionally substituted carbamoyl group, or R.sub.3 and R.sub.4 may be taken together to form a five-membered ring, or R.sub.5 and R.sub.6 may be taken together to form a cycloalkyl group, provided that when the five-membered ring formed by R.sub.3 and R.sub.4 and the benzene ring form benzofuran or benzo[b]thiophene, R.sub.6 is absent.Type: GrantFiled: December 17, 1998Date of Patent: October 17, 2000Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Osamu Cynshi, Yoshiaki Takashima, Kunio Tamura, Akira Ishikawa, Yoshiaki Kato
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Patent number: 5789436Abstract: A compound represented by formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a lower alkyl group or an acyl group; R.sub.2 and R.sub.3, which may be the same or different, each represents a hydrogen atom, an optionally substituted alkyl group, or an optionally substituted alkenyl group; R.sub.4 represents a hydrogen atom, an optionally substituted alkyl group, or an optionally substituted alkenyl group, or R.sub.4 forms a double bond between the carbon atom to which R.sub.3 is bonded and the adjacent carbon atom to form a benzothiophene skeleton, or R.sub.3 and R.sub.4 are taken together to form a 5- to 8-membered spiro ring which may contain a hetero atom, e.g., oxygen, sulfur or nitrogen; and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof. The compound of formula (I) exhibits an inhibitory action on the oxidative modification of LDL and is useful as therapeutics of arteriosclerosis.Type: GrantFiled: October 9, 1996Date of Patent: August 4, 1998Assignee: Chugai Seiyak Kabushiki KaishaInventors: Yoshiaki Kato, Akira Ishikawa, Kunio Tamura
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Patent number: 5663373Abstract: Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: August 21, 1996Date of Patent: September 2, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 5606089Abstract: Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: May 18, 1995Date of Patent: February 25, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 5574178Abstract: Compounds represented by the general formula as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: April 17, 1995Date of Patent: November 12, 1996Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 4732057Abstract: An improved bottle opening machine for smoothly removing crown caps from bottle necks of empty bottles contained in bottle cases which are being conveyed on a conveyance system in a single file, in which the cap removing is carried out by the steps of engaging of cap removing sections on rotary discs with the crown caps on the bottle necks in an area where the circular movement path of the cap removing sections and the linear movement path of the bottle necks mutually converge in the tangential direction, removing of the crown caps from the bottle necks under the influence of a moment which is produced as the former is separated from the latter as the rotary discs are rotated, and releasing of the removed crown caps from the cap removing sections with the aid of cap releasing mechanisms. To ensure that the cap removing sections are positioned correctly with corresponding bottle necks, at least a synchronizing means is rotatably mounted on the frame structure.Type: GrantFiled: February 13, 1986Date of Patent: March 22, 1988Assignee: Kirin Beer Kabushiki KaishaInventors: Kunio Tamura, Takayuki Horiai
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Patent number: 4597314Abstract: An improved bottle opening machine for smoothly removing crown caps from bottle necks of empty bottles contained in bottle cases which are being conveyed on a conveyance system in a single file, in which the cap removing is carried out by the steps of engaging of cap removing sections on rotary discs with the crown caps on the bottle necks in an area where the circular movement path of the cap removing sections and the linear movement path of the bottle necks mutually converge in the tangential direction, removing of the crown caps from the bottle necks under the influence of a moment which is produced as the former is separated from the latter as the rotary discs are rotated, and releasing of the removed crown caps from the cap removing sections with the aid of cap releasing mechanisms. To ensure that the cap removing sections are positioned correctly with corresponding bottle necks, at least a synchronizing means is rotatably mounted on the frame structure.Type: GrantFiled: October 24, 1983Date of Patent: July 1, 1986Assignee: Kirin Beer Kabushiki KaishaInventors: Kunio Tamura, Takayuki Horiai
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Patent number: 4562565Abstract: A tracking servo system of a recording-disc reading and reproducing apparatus in which the information carried on a recording disc adapted to be driven for rotation is scanned by a signal pickup point displaced radially of the disc, comprising tracking error signal generator operative to detect an amount of deviation, if any, of the signal pickup medium from a target track on an information-carrying surface of the recording disc and produce a tracking error signal representative of the detected amount of deviation, and band eliminator such as a notch filter operative to eliminate a predetermined frequency in the tracking error signal.Type: GrantFiled: September 13, 1982Date of Patent: December 31, 1985Assignee: Pioneer Electronic CorporationInventor: Kunio Tamura