Patents by Inventor Kunitoshi Yamanaka

Kunitoshi Yamanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using a gene conferring resistance to 4,5-dihydroxy-2-cyclopenten-1-one (DHCP) and identifying inhibitors of a polypeptide encoded by the gene
    Patent number: 7476526
    Abstract: The invention relates to a gene isolated from E. coli, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: January 13, 2009
    Assignee: Takara Bio Inc.
    Inventors: Sangita Phadtare, Kunitoshi Yamanaka, Ikunoshin Kato, Masayori Inouye
  • Cold-shock regulatory elements, constructs thereof, and method of use
    Patent number: 7429654
    Abstract: Regulatory elements of the 5?UTR of cold-shock inducible genes that prolong the expression of cold-shock inducible genes under conditions that elicit the cold-shock response in a bacterium, repress the expression of the cold-shock inducible genes under physiological conditions, or enhance the translation of cold-shock inducible genes under conditions that elicit a cold-shock response in bacteria; vectors incorporating these elements; and methods for expressing proteins.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: September 30, 2008
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Li Fang, Weining Jiang, Masanori Mitta, Masayori Inouye, Jean-Pierre Etchegaray, Kunitoshi Yamanaka
  • Method of gene encoding a 4,5-dihydroxy-2-cyclopenten-1-one (DHCP) efflux protein promoting resistance to DHCP
    Publication number: 20070166786
    Abstract: The invention relates to a gene, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
    Type: Application
    Filed: September 12, 2005
    Publication date: July 19, 2007
    Applicant: Takara Bio, Inc. a corporation of Japan
    Inventors: Sangita Phadtare, Kunitoshi Yamanaka, Ikunoshin Kato, Masayori Inouye
  • Heat shock protein inducer
    Patent number: 6846845
    Abstract: A heat shock protein inducer is provided for purposes of preventing or treating ischemic disease or ischemia/reperfusion injury. This heat shock protein inducer has geranylgeranylacetone as an active ingredient and induces heat shock proteins in the heart.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: January 25, 2005
    Assignees: Eisai Co., Ltd.
    Inventors: Naohiko Takahashi, Tatsuhiko Ooie, Toshiie Sakata, Kunitoshi Yamanaka, Tomoko Nawata, Masaya Arikawa, Masahide Hara, Tetsunori Saikawa, Tatsuo Shimada, Hironobu Yoshimatsu
  • Cold-shock regulatory elements, constructs thereof, and methods of use
    Patent number: 6610533
    Abstract: A fourth cold shock protein of the Escherichia coli CspA family is disclosed, as are the regulatory elements of the 5′ UTR of the corresponding gene. The cspI gene is located at 35.2 min on the E. coli chromosome map, and CspI shows 70, 70, and 79% identity of CspA, CspB, and CspG, respectively. The 5′-untranslated region of the cspI mRNA consists of 145 bases and causes a negative effect on cspI expression at 37° C. The cspI mRNA was very unstable at 37° C. but was stabilized upon cold shock. The 5′ UTR of cspI can enhance the translation of cold shock inducible genes under conditions that elicit a cold shock response in bacteria.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: August 26, 2003
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Masayori Inouye, Nan Wang, Kunitoshi Yamanaka
  • Heat shock protein inducer
    Publication number: 20030134907
    Abstract: A heat shock protein inducer is provided for purposes of preventing or treating ischemic disease or ischemia/reperfusion injury. This heat shock protein inducer has geranylgeranylacetone as an active ingredient and induces heat shock proteins in the heart.
    Type: Application
    Filed: August 29, 2002
    Publication date: July 17, 2003
    Inventors: Naohiko Takahashi, Tatsuhiko Ooie, Toshiie Sakata, Kunitoshi Yamanaka, Tomoko Nawata, Masaya Arikawa, Masahide Hara, Tetsunori Saikawa, Tatsuo Shimada, Hironobu Yoshimatsu
  • Gene conferring resistance to the antibacterial 4,5-dihydroxy-2-cyclopenten-1-one (DHCP), the protein encoded by same, and applications thereof
    Publication number: 20020143163
    Abstract: The invention relates to a gene, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
    Type: Application
    Filed: March 14, 2001
    Publication date: October 3, 2002
    Applicant: The University of Medicine and Dentistry of New Jersey
    Inventors: Sangita Phadtare, Kunitoshi Yamanaka, Ikunoshin Kato, Masayori Inouye