Patents by Inventor Kuniya Sakurai

Kuniya Sakurai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of the GPIb-vWF interaction, their preparation and use
    Patent number: 7745443
    Abstract: The present invention relates to compounds of the formula I, in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below. The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of atherothrombotic diseases.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: June 29, 2010
    Assignees: Sanofi-Aventis Deutschland GmbH, Ajinomoto Co., Inc.
    Inventors: Otmar Klingler, Melitta Just, Kuniya Sakurai, Naoyuki Fukuchi
  • Inhibitors of the GPIb-vWF interaction, their preparation and use
    Publication number: 20070173489
    Abstract: The present invention relates to compounds of the formula I, in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below. The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of atherothrombotic diseases.
    Type: Application
    Filed: April 2, 2007
    Publication date: July 26, 2007
    Inventors: Otmar Klingler, Melitta Just, Kuniya Sakurai, Naoyuki Fukuchi
  • Inhibitors of the GPIb—vWF interaction, their preparation and use
    Patent number: 7235558
    Abstract: The present invention relates to compounds of the formula I, in which R1, R2, A, B, D, F, n, m and o have the meanings indicated herein. The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb).
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 26, 2007
    Assignees: Sanofi-Aventis Deutschland GmbH, Ajinomoto Co., Inc
    Inventors: Otmar Klingler, Melitta Just, Kuniya Sakurai, Naoyuki Fukuchi
  • Benzodiazepine derivatives
    Patent number: 6825191
    Abstract: The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: November 30, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadakiyo Nakagawa, Munetaka Tokumasu, Kazumi Tashiro, Mitsuo Takahashi, Takashi Kayahara, Shunji Takehana, Yuki Kajigaya, Kaoru Yoshida, Kuniya Sakurai
  • Inhibitors of the GPIb-vWF interaction, their preparation and use
    Publication number: 20040067980
    Abstract: The present invention relates to compounds of the formula I, 1
    Type: Application
    Filed: June 4, 2003
    Publication date: April 8, 2004
    Inventors: Otmar Klingler, Melitta Just, Kuniya Sakurai, Naoyuki Fukuchi
  • Amidinophenylpyruvic acid derivatives
    Patent number: 6710056
    Abstract: An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: March 23, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masayuki Sugiki, Kazuyuki Sagi, Kohichi Fujita, Takashi Kayahara, Shunji Takehana, Kuniya Sakurai, Kazumi Tashiro
  • Benzodiazepine derivatives
    Publication number: 20030186969
    Abstract: The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 2, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Tadakiyo Nakagawa, Munetaka Tokumasu, Kazumi Tashiro, Mitsuo Takahashi, Takashi Kayahara, Shunji Takehana, Yuki Kajigaya, Kaoru Yoshida, Kuniya Sakurai
  • Amidinophenylpyruvic acid derivatives
    Publication number: 20030109547
    Abstract: An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.
    Type: Application
    Filed: June 5, 2002
    Publication date: June 12, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Masayuki Sugiki, Kazuyuki Sagi, Kohichi Fujita, Takashi Kayahara, Shunji Takehana, Kuniya Sakurai, Kazumi Tashiro
  • Optically active pyrrolidine derivative
    Patent number: 5342963
    Abstract: Optically active pyrrolidine derivative represented by the following formula (XI): ##STR1## wherein R.sup.1 represents a benzyl group R.sup.2 represents an alkyl group having 1 to 6 carbon atoms, R.sup.3 represents an alkyl group having 1 to 6 carbon atoms, a benzyl group or an allyl group, R.sup.4 is selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 6 carbon atoms which may be substituted with a protected hydroxyl group, a vinyl group, a phenyl group which may be substituted, a benzyl group which may be substituted, and a heterocyclic ring having 1 to 4 nitrogen or/and oxygen atoms, and R.sup.5 represents a hydrogen atom or a methyl group.This compound can be an intermediate for synthesis of carbapenem antibiotic compounds.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: August 30, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kuniya Sakurai, Kunisuke Izawa, Hiroyuki Izawa, Takashi Ineyama, Tomihisa Ohta, Shigeo Nozoe