Patents by Inventor Kunsang Yoon

Kunsang Yoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240108750
    Abstract: POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.
    Type: Application
    Filed: November 7, 2023
    Publication date: April 4, 2024
    Applicant: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Michael Bentley, Tacey Viegas, Randall Moreadith, Robert J Sharpe, Kunsang Yoon, Zhihao Fang, Rebecca Weimer
  • Patent number: 11944618
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: April 2, 2024
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Patent number: 11925689
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: January 4, 2022
    Date of Patent: March 12, 2024
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Publication number: 20230009076
    Abstract: The present disclosure provides for polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer. Methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions comprising a POZ conjugate are also provided.
    Type: Application
    Filed: June 28, 2020
    Publication date: January 12, 2023
    Applicant: SERINA THERAPEUTICS, INC.
    Inventors: J Milton HARRIS, Michael D BENTLEY, Tacey X VIEGAS, Randall W MOREADITH, Zhihao FANG, Kunsang YOON, Rebecca WEIMER
  • Publication number: 20220354841
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: April 11, 2022
    Publication date: November 10, 2022
    Applicant: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Publication number: 20220249695
    Abstract: POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.
    Type: Application
    Filed: February 4, 2022
    Publication date: August 11, 2022
    Applicant: Serina Therapeutics, Inc.
    Inventors: J Milton HARRIS, Michael Bentley, Tacey Viegas, Randall Moreadith, Robert J. Sharpe, Kunsang Yoon, Zhihao Fang, Rebecca Weimer
  • Publication number: 20220193243
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: January 4, 2022
    Publication date: June 23, 2022
    Applicant: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Patent number: 11298350
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: April 12, 2022
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Patent number: 11224595
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: January 18, 2022
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Michael Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
  • Patent number: 11213588
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: January 4, 2022
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Patent number: 10864276
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: December 15, 2020
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas, Francesco Maria Veronese, Anna Mero
  • Publication number: 20200093816
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: September 30, 2019
    Publication date: March 26, 2020
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Patent number: 10426768
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 1, 2019
    Assignee: Sarina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Publication number: 20190290638
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Application
    Filed: June 10, 2019
    Publication date: September 26, 2019
    Inventors: Randall MOREADITH, Michael BENTLEY, Kunsang YOON, Zhihao FANG, Rebecca WEIMER, Bekir DIZMAN, Tacey VIEGAS
  • Patent number: 10314837
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
  • Publication number: 20190134208
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: December 28, 2018
    Publication date: May 9, 2019
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Publication number: 20190070301
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 7, 2019
    Inventors: J. Milton HARRIS, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas, Francesco Maria Veronese, Anna Mero
  • Patent number: 10166294
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: January 1, 2019
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Kunsang Yoon, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Patent number: 10086084
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: October 2, 2018
    Assignee: Serina Therapeutics, Inc.
    Inventors: J Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese, Tacey Viegas
  • Publication number: 20170202972
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 20, 2017
    Inventors: Randall MOREADITH, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley