Patents by Inventor Kunyuan Song
Kunyuan Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11773073Abstract: This application discloses a method for synthesizing myricetin, which includes the following steps: adding an alkaline solution to an aqueous solution of dihydromyricetin, and heating under a reflux state after the addition; adding an aqueous solution of selenium dioxide, stirring at a reflux temperature after the addition, and cooling to room temperature after the reaction is complete; adding acid to adjust pH, stirring, rotary evaporation, stirring, and filtering; adding an aqueous solution of ethanol to a filter cake to make a slurry, filtering, washing the filter cake with the aqueous solution of ethanol, collecting the filter cake and drying to obtain red selenium; combining organic phases, spin-drying until there is no ethanol smell, precipitating a large amount of solids, filtering, and washing the filter cake with the aqueous solution of ethanol to obtain a yellow solid which is myricetin. The advantages of the disclosure are: 1. simple and easy to operate the reaction; 2.Type: GrantFiled: May 8, 2020Date of Patent: October 3, 2023Assignee: SHANGHAI YINSHENG CONSULTING CORPORATION (LIMITED LIABILITY PARTNERSHIP)Inventor: Kunyuan Song
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Patent number: 11618741Abstract: The present disclosure provides a method for preparing diselenide compound. A polar solvent is added to a dihydroflavonol compound, heated to 80° C.˜100° C., kept for 40˜50 minutes, then the base in the amount of 0.4˜1.0 times the amount of the dihydroflavonol compound is added and reacted at 80° C.˜100° C. for 5˜60 minutes, then selenium dioxide in the amount of 0.6˜1.2 times the amount of dihydroflavonol compounds at 80° C.˜100° C. The diselenide compound of the dihydroflavonol compound is obtained by reacting at a temperature of 80° C.˜100° C. for 30˜150 minutes. The method of the present disclosure has mild reaction, low pollution, does not require an anhydrous and oxygen-free environment, and is suitable for large-scale industrial production.Type: GrantFiled: June 18, 2020Date of Patent: April 4, 2023Assignee: SHANGHAI SPARK PHARMACEUTICAL CO., LTD.Inventors: Kunyuan Song, Weiwei Chen
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Publication number: 20220194915Abstract: This application discloses a method for extracting and separating dihydromyricetin from rattan tea, which belongs to the technical field of natural medicine extraction and separation. The specific steps are as follows: 1) weighing rattan tea leaves, then adding solvent thereto, stirring and refluxing to extract, filtering, keeping on refluxing extraction of residue, and combining extract; 2) adding activated carbon to the extract, performing decolorization, filtering, retaining the filtrate, and then concentrating the filtrate; and 3) crystallizing the concentrated filtrate, filtering, and washing the crystals with cold water and vacuum drying. The invention disclosure has simple process, high yield and stability, and is easy to realize industrialized production.Type: ApplicationFiled: May 8, 2020Publication date: June 23, 2022Inventors: Kunyuan SONG, Gong CHEN, Weiwei CHEN, Fang YAN
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Publication number: 20220081405Abstract: The present disclosure provides a method for preparing diselenide compound. A polar solvent is added to a dihydroflavonol compound, heated to 80° C.˜100° C., kept for 40˜50 minutes, then the base in the amount of 0.4˜1.0 times the amount of the dihydroflavonol compound is added and reacted at 80° C.˜100° C. for 5˜60 minutes, then selenium dioxide in the amount of 0.6˜1.2 times the amount of dihydroflavonol compounds at 80° C.˜100° C. The diselenide compound of the dihydroflavonol compound is obtained by reacting at a temperature of 80° C.˜100° C. for 30˜150 minutes. The method of the present disclosure has mild reaction, low pollution, does not require an anhydrous and oxygen-free environment, and is suitable for large-scale industrial production.Type: ApplicationFiled: June 18, 2020Publication date: March 17, 2022Inventors: Kunyuan SONG, Weiwei CHEN
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Publication number: 20220079913Abstract: This application discloses a new use of dihydromyricetin, that is, its application in preparing foods, health products or medicines with anti-alcoholic effect. Its advantages are: dihydromyricetin has a good function of dispeling the effects of alcohol. Dihydromyricetin can increase the expression of GABAARs a4 subgroup in the hippocampus and neurons, and play a role in resisting alcoholism and alcohol dependence. Dihydromyricetin can also effectively prevent the depletion of reduced glutathione and increase of malondialdehyde in the liver caused by alcohol, as well as reducing triglyceride content, reducing the degree of fatty degeneration of liver cells, and has a better effect of preventing and treating alcoholic liver injury.Type: ApplicationFiled: June 18, 2020Publication date: March 17, 2022Inventors: KUNYUAN SONG, WEIWEI CHEN
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Publication number: 20220071947Abstract: The present disclosure provides a pharmaceutical application of dimyricetin-based diselenide. Dimyricetin-based diselenide has the effect of treating tumors and resistance of new coronavirus, and has obvious inhibitory effects on 7 different human-derived tumor cells. The IC50 value of Mpro, the target of the new coronavirus (2019-nCoV), is 0.807±0.0830 ?M, which has a significant effect.Type: ApplicationFiled: June 18, 2020Publication date: March 10, 2022Inventors: KUNYUAN SONG, WEIWEI CHEN
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Publication number: 20220073486Abstract: This application discloses a method for synthesizing myricetin, which includes the following steps: adding an alkaline solution to an aqueous solution of dihydromyricetin, and heating under a reflux state after the addition; adding an aqueous solution of selenium dioxide, stirring at a reflux temperature after the addition, and cooling to room temperature after the reaction is complete; adding acid to adjust pH, stirring, rotary evaporation, stirring, and filtering; adding an aqueous solution of ethanol to a filter cake to make a slurry, filtering, washing the filter cake with the aqueous solution of ethanol, collecting the filter cake and drying to obtain red selenium; combining organic phases, spin-drying until there is no ethanol smell, precipitating a large amount of solids, filtering, and washing the filter cake with the aqueous solution of ethanol to obtain a yellow solid which is myricetin. The advantages of the disclosure are: 1. simple and easy to operate the reaction; 2.Type: ApplicationFiled: May 8, 2020Publication date: March 10, 2022Inventor: Kunyuan SONG
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Publication number: 20220040142Abstract: The present disclosure provides a pharmaceutical application for the inhibition of novel coronaviruses by myricetin, which was shown to bind the 2019-nCoV-Mpro protease with a significant effect against the novel coronavirus (2019-nCoV) with an IC50 value of 0.582±0.0912 ?M for the target Mpro, and was able to inhibit the 2019-nCoV virus.Type: ApplicationFiled: June 18, 2020Publication date: February 10, 2022Inventors: Kunyuan SONG, Weiwei CHEN
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Patent number: 10501431Abstract: A selenium-enriched tea polyphenol selenide, has such a structure as wherein R1 is alkali metal ion and selenium coordination complex, and R2?H, or A method for preparing the selenium-enriched tea polyphenol selenide, comprises: A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy acid salt; and B) reacting the tea polyphenol hydroxy acid salt with SeO2, to obtain the selenium-enriched tea polyphenol selenide.Type: GrantFiled: March 26, 2014Date of Patent: December 10, 2019Assignee: Shanghai Ai Qi Ecological Technology Co., Ltd.Inventors: Gong Chen, Kunyuan Song
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Publication number: 20190144412Abstract: A selenium-enriched tea polyphenol selenide, has such a structure as: wherein R1 is alkali metal ion and selenium coordination complex, and R2?H, or A method for preparing the selenium-enriched tea polyphenol selenide, comprises: A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy acid salt; and B) reacting the tea polyphenol hydroxy acid salt with SeO2, to obtain the selenium-enriched tea polyphenol selenide.Type: ApplicationFiled: March 26, 2014Publication date: May 16, 2019Inventors: Gong Chen, Kunyuan Song
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Patent number: 9637448Abstract: A trans-resveratrol selenide for treating cancer has such a structure as: wherein hydroxyls at position 3, 4 and 5 are replaceable, at least one hydroxyl at position 3, 4, 5 is replaced with R, R is alkali metal ion and selenium coordination complex, and The trans-resveratrol selenide preparation is able to treat various cancers, such as lung cancer, lymphoma, stomach cancer, liver cancer, small intestine cancer, colorectal cancer and gynecologic cancer, and has a good curative effect.Type: GrantFiled: March 28, 2014Date of Patent: May 2, 2017Assignee: Shanghai Ai Qi Ecological Technology Co., Ltd.Inventors: Gong Chen, Kunyuan Song
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Patent number: 9464046Abstract: A method for preparing selenium compounds, comprising following steps of: A. hydrolyzing lignin to obtain multiple-structural polyphenolic compounds; B. reacting the multiple-structural polyphenolic compounds with at least one kind of inorganic metal base to obtain multivalent phenolic hydroxyl carboxylate; and C. reacting the multivalent phenolic hydroxyl carboxylate with SeO2 to obtain multivalent phenolic hydroxyl carboxylic acid selenium complex salts, wherein the multivalent phenolic hydroxyl carboxylic acid selenium complex salts are organic selenium composition. The multivalent phenolic hydroxyl carboxylic acid selenium complex salts have characteristics of over 20% selenium content and no toxicity, and have revolutionary effects in killing bacteria, virus and cancer cell, enhancing human immunity, removing oxygen free radicals and etc.Type: GrantFiled: July 3, 2013Date of Patent: October 11, 2016Assignee: Shanghai Ai Qi Ecological Technology Co. Ltd.Inventors: Gong Chen, Kunyuan Song
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Patent number: 9353105Abstract: A compound medicine for treating acute and chronic hepatitis B, includes a polyphenolic selenium compound having a functional group of alkali metal ion and selenium coordination complex, which has functions of directly killing HBV and destroying replication template of HBV. Auxiliary formulas thereof include high-purity oxymatrine and glycyrrhizin sulfate. The oxymatrine has an effect of anti-HBV, and is capable of treating acute and chronic hepatitis B, regulating immune system and increasing leukocyte. Serving as a main hepatocyte membrane protective agent, the glycyrrhizin sulfate has not only an effect of anti-inflammation, but also it is capable of regulating immune system and protecting hepatocyte. The compound medicine has no toxicity or side effect.Type: GrantFiled: February 13, 2014Date of Patent: May 31, 2016Assignee: Shanghai Ai Qi Ecological Technology Co., Ltd.Inventors: Gong Chen, Kunyuan Song
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Publication number: 20160068481Abstract: A trans-resveratrol selenide for treating cancer has such a structure as: wherein hydroxyls at position 3, 4 and 5 are replaceable, at least one hydroxyl at position 3, 4, 5 is replaced with R, R is alkali metal ion and selenium coordination complex, and The trans-resveratrol selenide preparation is able to treat various cancers, such as lung cancer, lymphoma, stomach cancer, liver cancer, small intestine cancer, colorectal cancer and gynecologic cancer, and has a good curative effect.Type: ApplicationFiled: March 28, 2014Publication date: March 10, 2016Inventors: Gong Chen, Kunyuan Song
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Publication number: 20150353536Abstract: A compound medicine for treating acute and chronic hepatitis B, includes a polyphenolic selenium compound having a functional group of alkali metal ion and selenium coordination complex, which has functions of directly killing HBV and destroying replication template of HBV. Auxiliary formulas thereof include high-purity oxymatrine and glycyrrhizin sulfate. The oxymatrine has an effect of anti-HBV, and is capable of treating acute and chronic hepatitis B, regulating immune system and increasing leukocyte. Serving as a main hepatocyte membrane protective agent, the glycyrrhizin sulfate has not only an effect of anti-inflammation, but also it is capable of regulating immune system and protecting hepatocyte. The compound medicine has no toxicity or side effect.Type: ApplicationFiled: February 13, 2014Publication date: December 10, 2015Inventors: Gong Chen, Kunyuan Song
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Publication number: 20140323745Abstract: A polyphenolic selenium compound having a functional group of alkali metal ion and selenium complex which has an aromatic ring is provided, wherein the aromatic ring comprises at least two functional groups, each of which is one member selected from the group consisting of oxygen functional group, sulphur functional group, phosphorus functional group and nitrogen functional group; and selenium complex functional group is formed by selenium, alkali metal ion and the functional group. The polyphenolic selenium compound having a functional group of alkali metal ion and selenium complex of the present invention has characteristics of over 20% selenium content and no toxicity. Because it has revolutionary effects in killing bacteria, virus and cancer cell, enhancing human immunity, removing oxygen free radicals and etc., it holds a vital medicinal value.Type: ApplicationFiled: January 18, 2014Publication date: October 30, 2014Applicant: Shanghai Ai Qi Ecological Technology Co., Ltd.Inventors: Gong Chen, Kunyuan Song