Patents by Inventor Kuo-I Lin

Kuo-I Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136668
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Application
    Filed: November 8, 2024
    Publication date: May 1, 2025
    Inventors: Kuo-I LIN, Che MA, Chi-Huey WONG, Szu-Wen WANG, Yi-Hsuan CHANG, Xiaorui CHEN, Han-Yi HUANG
  • Publication number: 20250082744
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Application
    Filed: October 25, 2024
    Publication date: March 13, 2025
    Inventors: Chi-Huey WONG, Hsin-Yu LIAO, Shih-Chi WANG, Yi-An KO, Kuo-I LIN, Che MA, Ting-Jen CHENG
  • Patent number: 12178870
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Grant
    Filed: May 13, 2024
    Date of Patent: December 31, 2024
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Hsin-Yu Liao, Shih-Chi Wang, Yi-An Ko, Kuo-I Lin, Che Ma, Ting-Jen Cheng
  • Patent number: 12157763
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Grant
    Filed: January 3, 2024
    Date of Patent: December 3, 2024
    Assignee: Academia Sinica
    Inventors: Kuo-I Lin, Che Ma, Chi-Huey Wong, Szu-Wen Wang, Yi-Hsuan Chang, Xiaorui Chen, Han-Yi Huang
  • Publication number: 20240316179
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Application
    Filed: May 13, 2024
    Publication date: September 26, 2024
    Inventors: Chi-Huey WONG, Hsin-Yu LIAO, Shih-Chi WANG, Yi-An KO, Kuo-I LIN, Che MA, Ting-Jen CHENG
  • Publication number: 20240228591
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-COV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Application
    Filed: January 3, 2024
    Publication date: July 11, 2024
    Inventors: Kuo-I LIN, Che MA, Chi-Huey WONG, Szu-Wen WANG, Yi-Hsuan CHANG, Xiaorui CHEN, Han-Yi HUANG
  • Patent number: 11992525
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: May 28, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Hsin-Yu Liao, Shih-Chi Wang, Yi-An Ko, Kuo-I Lin, Che Ma, Ting-Jen Cheng
  • Publication number: 20240100147
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Application
    Filed: November 3, 2023
    Publication date: March 28, 2024
    Inventors: Chi-Huey WONG, Hsin-Yu LIAO, Shih-Chi WANG, Yi-An KO, Kuo-I LIN, Che MA, Ting-Jen CHENG
  • Patent number: 11918641
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: March 5, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Hsin-Yu Liao, Shih-Chi Wang, Yi-An Ko, Kuo-I Lin, Che Ma, Ting-Jen Cheng
  • Patent number: 11866485
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: January 9, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Kuo-I Lin, Che Ma, Chi-Huey Wong, Szu-Wen Wang, Yi-Hsuan Chang, Xiaorui Chen, Han-Yi Huang
  • Publication number: 20230302114
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Application
    Filed: May 7, 2021
    Publication date: September 28, 2023
    Inventors: Chi-Huey WONG, Hsin-Yu LIAO, Shih-Chi WANG, Yi-An KO, Kuo-I LIN, Che MA, Ting-Jen CHENG
  • Publication number: 20230279080
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that is specific for a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Application
    Filed: December 27, 2022
    Publication date: September 7, 2023
    Inventors: Kuo-I LIN, Chi-Huey WONG, Szu-Wen WANG, Yi-Hsuan CHANG
  • Publication number: 20230105209
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Application
    Filed: October 3, 2022
    Publication date: April 6, 2023
    Inventors: Kuo-I LIN, Che MA, Chi-Huey WONG, Szu-Wen WANG, Yi-Hsuan CHANG, Xiaorui CHEN, Han-Yi HUANG
  • Publication number: 20220338678
    Abstract: A processor-changeable multipurpose food preparation machine, comprises a actuator and a processor, a fixing base is arranged outside the insertion hole of the actuator, the outer end has a coupling mouth, the upper end has a first feed inlet, the two side ends have a first fixing part; the tail end of the processor includes a feeding base, the upper end has a second feed inlet, the two side ends have a second fixing part; the feeding base is inserted in the coupling mouth of fixing base and fixed into the fixing base, the second feed inlet corresponds to the lower part of the first feed inlet, when the second fixing part is coordinated with the first fixing part, the feeding base and fixing base are combined by a fastener, the processor can be assembled or changed easily and quickly, the operation is convenient and easily learned.
    Type: Application
    Filed: May 6, 2021
    Publication date: October 27, 2022
    Inventors: KUO-I LIN, FU-CHEN LIN
  • Publication number: 20210301318
    Abstract: The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of A S using such animal model.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 30, 2021
    Applicants: ACADEMIA SINICA, BUDDHIST TZU CHI MEDICAL FOUNDATION, CHINA MEDICAL UNIVERSITY
    Inventors: Kuo-I LIN, Shih-Chieh HUNG, Chin-Hsiu LIU
  • Patent number: 8906380
    Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: December 9, 2014
    Assignee: Academia Sinica
    Inventors: Alice Yu, John Yu, Kuo-I Lin, Wen-Bin Yang, Chi-Huey Wong
  • Publication number: 20070231339
    Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.
    Type: Application
    Filed: October 13, 2006
    Publication date: October 4, 2007
    Applicant: ACADEMIA SINICA
    Inventors: Alice Yu, John Yu, Kuo-I Lin, Wen-Bin Yang, Chi-Huey Wong
  • Publication number: 20050284301
    Abstract: A water cleaning dust-filtering device comprises a casing being a long hollow container; a bottom thereof being formed with a round hole; an L shape tube installed in the casing; a stopper being isolated into an upper chamber and a lower chamber; the stopper being a folded plate; a lower cover movably installed to a lower end of the casing; an interior of the lower cover having a dust-collector groove; an upper cover movably installed to a top end of the casing; a top thereof having an outlet; a first filter net installed with the dust-collector groove of the lower cover for filtering larger scale particles; and a second filter net for filtering water particles and the filter net being installed in the opening of the upper cover and a joint installed in the outlet of the upper cover; and a joint connected to a guide tube of a vacuum cleaner.
    Type: Application
    Filed: June 23, 2004
    Publication date: December 29, 2005
    Inventors: Rong-Yuan Tseng, Kuo-I Lin
  • Patent number: 6967311
    Abstract: A smolder pot capable of cooking food as heat source is removed. The smolder pot comprises a cooking pot. At least one heat accumulating disk is fixed to a center of a bottom of the cooking pot; the heat accumulating disk being retained with a gap from the bottom. When the bottom of the cooking pot is heat, the heat accumulating disk will be heated. Due to the gap between the heat accumulating disk and the bottom, no heat is transferred to the cooking pot directly. Thus the temperature of the heat accumulating disk is not effect by the heat dissipating of liquid in the cooking pot. Thereby the heat accumulating effect of the heat accumulating disk is helpful to the heating and temperature retaining of the cooking pot.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: November 22, 2005
    Inventors: Rong-Yuan Tseng, Kuo-I Lin
  • Patent number: D506902
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: July 5, 2005
    Inventors: Rong-Yuan Tseng, Kuo-I Lin