Patents by Inventor Kuo S. Yang

Kuo S. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline antibiotic salt
    Patent number: 4594417
    Abstract: Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for its preparation are provided.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 10, 1986
    Assignee: Eli Lilly Company
    Inventor: Kuo S. Yang
  • Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
    Patent number: 4400503
    Abstract: Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for its preparation are provided.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: August 23, 1983
    Assignee: Eli Lilly and Company
    Inventor: Kuo S. Yang
  • Antibiotic crystalline epimer
    Patent number: 4252953
    Abstract: Crystalline D-diammonium salt represented by the formula ##STR1## a useful pharmaceutical form of the corresponding antibiotic diacid is provided and processes for the preparation thereof.
    Type: Grant
    Filed: May 1, 1979
    Date of Patent: February 24, 1981
    Assignee: Eli Lilly and Company
    Inventor: Kuo S. Yang
  • Process for crystalline sodium cefamandole
    Patent number: 4168376
    Abstract: A suspension of substantially pure sodium 7-(D-.alpha.-formyloxy-.alpha.-phenylacetamido)-3-(1-methyl-1H-tetrazol-5- ylthiomethyl)-3-cephem-4-carboxylate in methyl alcohol containing about 2% water on treatment with a methyl alcohol solution of sodium hydroxide is converted to a crystalline suspension of sodium 7-(D-.alpha.-hydroxy-.alpha.-phenylacetamido)-3-(1-methyl-1H-tetrazol-5-yl thiomethyl)-3-cephem-4-carboxylate in yields of about 65 to 70%.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: September 18, 1979
    Assignee: Eli Lilly and Company
    Inventor: Kuo S. Yang
  • Sodium cefamandole crystalline forms
    Patent number: 4054738
    Abstract: Sodium 7-(D-2-hydroxy-2-phenylacetamido)-3-(1-methyl-1H-tetrazole-5-ylthiomethyl) -3-cephem-4-carboxylate is obtained as a pharmaceutically acceptable crystalline anhydrate via crystalline methanolate or crystalline monohydrate forms.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: October 18, 1977
    Assignee: Eli Lilly and Company
    Inventor: Kuo S. Yang
  • Crystalline form of sodium O-formylcefamandole
    Patent number: 4006138
    Abstract: The cephalosporin antibiotic, sodium 7-(D-.alpha.-formyloxy-.alpha.-phenylacetamido)-3-(1-methyl-1H-tetrazol-5- ylthiomethyl)-3-cephem-4-carboxylate, is provided in a stable, non-solvated anhydrate crystalline form designated as the gamma crystalline form.
    Type: Grant
    Filed: April 11, 1975
    Date of Patent: February 1, 1977
    Assignee: Eli Lilly and Company
    Inventor: Kuo S. Yang