Abstract: Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises administering to the subject an effective amount of an inhibitor on inhibiting neddylation. According to some embodiments of the present disclosure, the inhibitor on inhibiting neddylation is a NAE inhibitor, which includes but is not limited to, MLN4924.

Abstract: Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises administering to the subject an effective amount of an inhibitor on inhibiting neddylation. According to some embodiments of the present disclosure, the inhibitor on inhibiting neddylation is a NAE inhibitor, which includes but is not limited to, MLN4924.

Abstract: A working electrode includes a conducting layer, a carbon nanotube layer electrophoretically deposited on the conducting layer; and a gold nanoparticle layer sputter-deposited on the carbon nanotube layer. A sensor chip having the working electrode and a method of fabricating the working electrode are also disclosed.

Abstract: The disclosure provides a composition for the treatment of osteomyelitis and a method for preparing the same. The composition includes: 100 parts by weight of water; 0.06-0.1 parts by weight of an antibiotic; and 5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following: wherein, R1 is hydrogen, or —C(?O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually are integers greater than 0.