Abstract: Embodiments of the disclosure provide an angiography image determination method and an angiography image determination device. The method includes: obtaining a plurality of first images of a body part injected with a contrast medium; obtaining a plurality of corresponding second images by performing a first image preprocessing operation on each first image; obtaining a pixel statistical characteristic of each second image; finding a candidate image based on the pixel statistical characteristic of each second image; and finding a reference image corresponding to the candidate image among the plurality of first images.