Patents by Inventor Kurt A. Morgenstern

Kurt A. Morgenstern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of hepatitis C virus helicase or fragments thereof comprising a helicase binding pocket
    Patent number: 7438920
    Abstract: The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: October 21, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Joseph L. Kim, Kurt Morgenstern, Paul Caron, Chao Lin
  • Generic probes for the detection of phosphorylated sequences
    Publication number: 20060089414
    Abstract: Generic probes that bind to phosphorylated amino acid residues are provided as well as methods employing the probes for screening for kinase inhibitory activity, kinase activity, and phosphatase activity. Methods for distinguishing serine/threonine kinase phosphorylation from tyrosine kinase phosphorylation are also provided.
    Type: Application
    Filed: July 22, 2005
    Publication date: April 27, 2006
    Inventors: Kurt Morgenstern, James Boyce, Stewart Chipman
  • Crystal of a kinase-ligand complex and methods of use
    Publication number: 20040204863
    Abstract: The invention relates to the three-dimensional structure of a crystal of a kinase enzyme complexed with a ligand. The three-dimensional structure of a protein kinase-ligand complex is disclosed. The invention also relates to methods of preparing such crystals. Kinase-ligand crystal structures wherein the ligand is an inhibitor molecule are useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods of using the crystal structure of kinase enzyme-ligand complexes for identifying, designing, selecting, or testing inhibitors of kinase enzymes, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by kinases; having one or more kinase enzymes involved in their pathology.
    Type: Application
    Filed: March 10, 2004
    Publication date: October 14, 2004
    Applicant: Amgen Inc.
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Paul E. Rose, Xiaotian Zhu
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Publication number: 20020042046
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Application
    Filed: September 14, 2001
    Publication date: April 11, 2002
    Applicant: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6303287
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: October 16, 2001
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
    Patent number: 6183121
    Abstract: The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: February 6, 2001
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Paul R. Caron, Chao Lin
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6153579
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: November 28, 2000
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson