Abstract: A system and method for using a portable device to communicate with a vehicle to authorize one or more vehicle operations. The portable device may authorize the vehicle to unlock/lock doors, start the vehicle engine, or mobilize the vehicle, or a combination thereof. The vehicle may include a vehicle transmitter system with one or more transmitters disposed at various locations on the vehicle, and the portable device may be configured to monitor a communication strength between the portable device and the one or more transmitters of the transmitter system. Based on the monitored signal strength, the portable device may determine location information about itself.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Devices, systems, and methods for coupling tubing to a fluid reservoir to provide liquid to an endoscope system. A manifold for coupling to a fluid reservoir and a tubing assembly may include first portion interfacing with an interior of the fluid reservoir and a second portion configured to interface with tubing to be fluidly coupled to the interior of the reservoir. The first portion may include one or more openings to allow gas to pass into the fluid reservoir and liquid to pass out of the fluid reservoir. The second portion may include one or more ports for connecting to tubing that brings gas to the fluid reservoir and receives liquid from the fluid reservoir. The manifold may include a valve that selectively allows gas to pass into the fluid reservoir.

Abstract: An apparatus for helping to protect an occupant of a vehicle in the event of a far-side collision in which the vehicle is impacted on a side opposite the seat in which the occupant is seated includes a curtain airbag configured to inflate and deploy from a roof of the vehicle in response to a far-side collision. The curtain airbag has an inflated and deployed condition in which the curtain airbag is positioned inboard of the vehicle occupant.

Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: Methods and systems for coupling gas and water supply tubes to a container. An illustrative container and tube set may comprise a container configured to contain a fluid, the container having a bottom portion and a top portion, a water supply tube including a first end, a second end, and a first lumen, a gas supply tube including a first end, a second end, and a second lumen, and a weight coupled to the first end of the water supply tube and a first end of the gas supply tube. The first lumen may be in selective fluid communication with the bottom portion of the container and the second end of the water supply tube positioned external to the container. The second lumen may be in operative fluid communication with the container and the second end of the gas supply tube is positioned external to the container.

Abstract: Embodiments in the disclosure are directed to the use of distributed computing to align reads against multiple portions of a reference dataset. Aligned portions of the reference dataset that correspond with an above-threshold alignment score can be assessed for the presence of sparse indicators that can be categorized and used to influence a determination of a state transition likelihood. Various tasks associated with the processing of reads (e.g., alignment, sparse indicator detection, and/or determination of a state transition likelihood) may be able to take advantage of parallel processing and can be distributed among the machines while considering the resource utilization of those machines. Different load-balancing mechanisms can be employed in order to achieve even resource utilization across the machines, and in some cases may involve assessing various processing characteristics that reflect a predicted resource expenditure and/or time profile for each task to be processed by a machine.

Abstract: Methods and systems disclosed herein relate generally to data processing by applying machine learning techniques to iteration data to identify anomaly subsets of iteration data. More specifically, iteration data for individual iterations of a workflow involving a set of tasks may contain a client data set, client-associated sparse indicators and their classifications, and a set of processing times for the set of tasks performed in that iteration of the workflow. These individual iterations of the workflow may also be associated with particular data sources. Using the iteration data, anomaly subsets within the iteration data can be identified, such as data items resulting from systematic error associated with particular data sources, sets of sparse indicators to be validated or double-checked, or tasks that are associated with long processing times. The anomaly subsets can be provided in a generated communication or report in order to optimize future iterations of the workflow.

Abstract: Methods and systems disclosed herein relate generally to data processing by applying machine learning techniques to iteration data to identify anomaly subsets of iteration data. More specifically, iteration data for individual iterations of a workflow involving a set of tasks may contain a client data set, client-associated sparse indicators and their classifications, and a set of processing times for the set of tasks performed in that iteration of the workflow. These individual iterations of the workflow may also be associated with particular data sources. Using the iteration data, anomaly subsets within the iteration data can be identified, such as data items resulting from systematic error associated with particular data sources, sets of sparse indicators to be validated or double-checked, or tasks that are associated with long processing times. The anomaly subsets can be provided in a generated communication or report in order to optimize future iterations of the workflow.

Abstract: Methods and systems disclosed herein relate generally to data processing by applying machine learning techniques to iteration data to identify anomaly subsets of iteration data. More specifically, iteration data for individual iterations of a workflow involving a set of tasks may contain a client data set, client-associated sparse indicators and their classifications, and a set of processing times for the set of tasks performed in that iteration of the workflow. These individual iterations of the workflow may also be associated with particular data sources. Using the iteration data, anomaly subsets within the iteration data can be identified, such as data items resulting from systematic error associated with particular data sources, sets of sparse indicators to be validated or double-checked, or tasks that are associated with long processing times. The anomaly subsets can be provided in a generated communication or report in order to optimize future iterations of the workflow.

Abstract: A surface mountable inductive component includes a miniature chip form having a main horizontal portion and supports extending therefrom, metalized pads connected to the supports for electrically connecting the chip form to a printed circuit board, and a wire wound about at least a portion of the main horizontal portion of the chip form and having first and second ends connected to respective metalized pads. The inductive component has a length to width ratio within the range of about 2.1 to about 2.

Abstract: A method of making and the resultant micro well plate that includes a plurality of greensheets, either laminated or sintered together, whereby these greensheets have a plurality of vertical micro well reaction chamber openings therein, and optionally a plurality horizontal channels connecting selected well reaction chamber openings. The vertical micro well reaction chambers have at, at least one end thereof a plurality of optical micro plugs which are aligned to the vertical micro well reaction chamber openings. The plurality of optical micro plugs allow for the micro well plate to be integrated with macro analytical instrumentation for the analysis, examination, and/or testing of chemicals, reagents or samples provided within the vertical micro well reaction chamber openings.

Abstract: A system for calculating a market value of an exotic option comprises an input means (102) for receiving market and option contract input data (112); a means (104) for calculating a theoretical value of an exotic option from the input data; a means (104) for calculating a market supplement adjustment to the theoretical value as a function of the expected stopping time of the exotic option; a means (104) for applying the market supplement adjustment to the theoretical value to produce the market value; and an output means (106) for outputting the calculated market value. The system may also calculate bid and offer prices from the market value. A method of obtaining the market value of an exotic option and a method of obtaining bid and offer prices of an exotic option are also disclosed.

Abstract: Methods and apparatus for maintaining a solid state disk drive facilitate expansion of storage capacity and maintenance of internal memory storage media, for example, are disclosed. Memory modules are adapted for removable installation in a solid state drive allowing for expansion of drive storage capacity and servicing of failed or worn out memory storage media. Data can be managed to mitigate loss during expansion, maintenance and servicing of the solid state drive.

Abstract: The present invention provides a method and apparatus in which a biometric information relating to a player is used to facilitate game play in multiplayer game environments. In particular, the present invention provides a game platform, a biofeedback sensor, and a biofeedback signal interface connection between the game platform and the biofeedback sensor. The biofeedback signal interface converts the biofeedback sensor information into a signal input usable by the game platform, which executes multimedia events as determined, in part, by the biometric information.

Abstract: A system is provided to align a surgical guide instrument over a burr hole in a patient's body. Adjustments of a surgical instrument can be made in x, y, z, and angular directions using the system. An instrument guide unit can include an instrument guide for guiding a surgical instrument into the body of a patient and a base unit operative to be secured to the body near an area in which surgery is to occur. The base unit is coupled to the instrument guide. An adjustment mechanism, coupled to the base unit and the instrument guide, is operative to adjust the instrument guide in lateral directions with respect the surface of the area.

Abstract: The present invention provides a novel ring type sensor for measuring biometric information. The ring sensor includes a rest for an appendage and a wing pivotally connected to the rest. A biasing member supplies a compressive force to the wing (relative to the rest) such that an appendage from which biometric information is to be measured is snuggly held by the rest and the wing.

Abstract: A component having a core, a first multi-wire bundle having primary and secondary windings wound about the core and a second multi-wire bundle having primary and secondary windings wound about the same core. In one form, the first and second bundles are wound in parallel with one another in a bifilar manner about the core. The method of winding the component allows the component to handle high current, high frequency data applications. An isolation transformer and filter circuit are also shown using the transformer and/or method of winding same.

Abstract: A system for use during a medical or surgical procedure on a body. The system generates a display representing the position of two or more body elements during the procedure based on a reference image data set generated by a scanner. The system produces a reference image of a body elements, discriminates the body elements in the images and creates an image data set representing the images of the body elements. The system produces a density image of the body element. The system modifies the image data set according to the density image of the body element during the procedure, generates a displaced image data set representing the position and geometry of the body element during the procedure, and compares the density image of the body element during the procedure to the reference image of the body element. The system also includes a display utilizing the displaced image data set generated by the processor to illustrate the position and geometry of the body element during the procedure.

Abstract: An apparatus consistent with the present invention comprises a sensor for receiving a signal representing eye tremor and a processor for monitoring eye tremor while receiving the signal. A method consistent with the present invention includes receiving a signal representing eye tremor, comparing the received signal representing eye tremor to at least one reference value, and classifying a patient's brain stem function using the comparison of the received signal representing eye tremor to at least one reference value.