Abstract: A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid.

Abstract: A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid.

Abstract: A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).

Abstract: A method for controlling yeast-to-filamentous growth transition in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid or an analog thereof. A method for treating fungal infections comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to control the fungal infection, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineactic acid or an analog thereof.

Abstract: The invention provides methods for identifying modulators of yeast phenotypic transitions and methods for treating fungal infections with modulators of phenotypic transitions of yeast cells. These methods include methods for identifying inhibitors of the budded-to-hyphal transition of Candida albicans and methods for treating fungal infections with inhibitors of the budded-to-hyphal transition of Candida albicans.

Abstract: A method for controlling yeast-to-filamentous growth transition in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid or an analog thereof. A method for treating fungal infections comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to control the fungal infection, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineactic acid or an analog thereof.

Abstract: The present invention relates to methods for reducing the growth of a fungus with an anti-fungal small molecule. Methods for reducing fungal cell growth in a subject with an anti-fungal small molecule and related compositions are provided. Topical lotion formulations of an anti-fungal small molecule and a topical carrier are also provided.

Abstract: The invention provides methods for identifying modulators of yeast phenotypic transitions and methods for treating fungal infections with modulators of phenotypic transitions of yeast cells. These methods include methods for identifying inhibitors of the budded-to-hyphal transition of Candida albicans and methods for treating fungal infections with inhibitors of the budded-to-hyphal transition of Candida albicans.

Abstract: A method for controlling yeast-to-filamentous growth transition in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid or an analog thereof. A method for treating fungal infections comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to control the fungal infection, wherein the anti-fungal small molecule is 5-(p-Bromobenzylidine)-?-isopropyl-4-oxo-2-thioxo-3-thiozolidineactic acid or an analog thereof.