Abstract: A method of fabricating a lens includes dispensing a first liquid optically-transmissive material into a first mold cavity and then curing the first liquid optically-transmissive material to form a first region the lens having a first refractive index and an optical interface surface. A second liquid optically-transmissive material then dispensed into a second mold cavity over the optical interface surface while the first region of the lens is disposed within the second mold cavity. The second liquid optically-transmissive material in the second mold cavity is cured to form a second region of the lens having a second refractive index. An optical interface between the first region and the second region conforms to the optical interface surface.

Abstract: The present invention relates to masked IL-15 cytokines, comprising an IL-15 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-15 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-15 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

Abstract: The present invention relates to masked IL-12 cytokines, comprising an IL-12 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-12 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-12 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

Abstract: The present invention relates to masked IL-2 cytokines, comprising an IL-2 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-2 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-2 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

Abstract: The present disclosure provides tumor-specific cleavable linkers and their use in drugs and prodrugs for delivering therapeutics to a tumor cell environment. The present disclosure also provides cleavage products of said drugs and prodrugs, and methods related to the use of the same.

Abstract: Fabricating a prescription optical element include providing a glass substrate layer and coupling an optical plastic layer to the glass substrate layer. A prescription surfaces is formed on an eyeward side of the optical plastic layer that is opposite an object side of the optical plastic layer. The object side is a planar surface that overlays the glass substrate layer and the glass substrate layer has a glass thickness to provide rigidity to the prescription optical element.

Abstract: An optical element includes a glass substrate layer and an optical plastic layer. The optical plastic layer has a planar surface. A prescription surface may be formed in the optical plastic layer opposite the planar surface.

Abstract: A lens assembly includes a tube in which optical elements such as lenses or micro-lenses are individually fabricated by dispensing a volume of curable optical polymer into the tube, forming the desired shape for the optical element using one or more plungers having heads corresponding to a desired lensing curvature, applying radiant energy to the tube with the plungers in place to cure the optical polymer, and repeating as needed until the desired number of optical elements are fabricated within the lens assembly which may then be integrated as a single piece into a mobile or wearable device.

Abstract: A curable liquid is provided to a mold having a rigid surface disposed opposite a deformable surface. The curable liquid contacts the rigid surface and the deformable surface. The deformable surface is shaped according to a surface profile by driving actuators configured to move the deformable surface. The curable liquid is cured while the deformable surface is shaped according to the surface profile.

Abstract: A lens assembly includes a tube in which optical elements such as lenses or micro-lenses are individually fabricated by dispensing a volume of curable optical polymer into the tube, forming the desired shape for the optical element using one or more plungers having heads corresponding to a desired lensing curvature, applying radiant energy to the tube with the plungers in place to cure the optical polymer, and repeating as needed until the desired number of optical elements are fabricated within the lens assembly which may then be integrated as a single piece into a mobile or wearable device.

Abstract: An optical element includes a Fresnel surface including valleys between Fresnel segments. Compensation trenches disposed in the valleys are configured to accept excess of an optical layer received in the valleys during a deposition of the optical layer. The compensation trenches are filled with the optical layer.

Abstract: A near-eye optical element includes light sources arranged with an illumination layer. The light sources are angled to direct light from the light sources to illuminate an ocular region.

Abstract: A housing for an optical assembly includes a base and at least one finger. The base includes a hole configured to pass light to or from an electronic component. The finger is bent at an angle with respect to the base for securing the optical assembly within the housing. The base and the finger comprise a single monolithic structure of a sheet material.

Abstract: Printed circuit boards include conductive metallic paths, such as vias, traces, and pads on the printed circuit board. One or more metal additive structures are additively manufactured onto the printed circuit boards in a manner that forms a continuous weld with at least one of the conductive metallic paths. As a result, the metal additive structures are continuous with the printed circuit board and do not require separate attachment mechanisms (e.g., soldering or mechanical fastening). The metal additive structures may include shield cans, frames, antennas, or heat sinks for the printed circuit board, for example.

Abstract: A lens with an internal aperture includes a first region of optically-transmissive material, a second region of optically-transmissive material, and an internal aperture element. The first region of optically transmissive material defines a first surface of the lens and the second region defines a second surface of the lens that is opposite the first surface. The internal aperture element is integrally disposed between the first region and the second region and defines the aperture of the lens.

Abstract: A Fresnel optical element includes a Fresnel surface formed in a material. The Fresnel surface includes a plurality of Fresnel feature that include an active surface and a draft surface. A light absorptive layer is selectively disposed over the draft surface of the Fresnel features. The light absorptive surface is configured to absorb a majority of visible light encountering the light absorptive layer.

Abstract: A method of fabricating coffee pods at a point of sale location using a coffee pod dispensing device with shell less, expandable coffee pods. The fabrication is initiated by tactile input from a control panel that determines the parameters of the coffee pods to be fabricated and generates the operational signals for the dispensing device. Fabrication there after progresses sequentially through a series of operations that involves the loading of the coffee pods onto a pod advancing means which then takes the coffee pods through the steps of expansion, filling, sealing and delivery. To accomplish this the pods are compressible pods arranged in a linear array that allows for pleated or stacked storage in a pod loading means within the device's enclosure, as well as continuous feed capabilities.

Abstract: A point of sale coffee pod dispensing device for use with shell less, expandable coffee pods. The compressible pods are arranged in a linear array that allows for pleated or stacked storage in a pod loading means within the device's enclosure, as well as continuous feed capabilities. The pod advancing means moves the pods from a pod loading station to the pod delivery station, there between sequentially passing through stations for pod expanding, coffee filling, and sealing. An operating system allows input of signals for the operation of the device based on tactile input from a control panel on the device's housing that determines the parameters of the coffee pods to be fabricated.

Abstract: A lost wax cast vapor chamber device is provided. Once a mesh is produced, a meltable core is formed from a meltable core material with the mesh positioned at least partially inside the core. Over the meltable core a metallic layer is formed, at least partially surrounding the meltable core. A chamber formed by the metallic layer is exposed by melting the meltable core to cause it to be removed from an internal void of the chamber, the internal void encapsulating the mesh. The melted material from the meltable core flows out an opening on at least one surface of the chamber. Subsequently, the internal void is filled at least partially with a working fluid and the opening is closed. The mesh supports the surfaces of the chamber against deformation under the vacuum of the internal void. Movement of working fluid by capillary action is facilitated by the mesh.

Abstract: Printed circuit boards include conductive metallic paths, such as vias, traces, and pads on the printed circuit board. One or more metal additive structures are additively manufactured onto the printed circuit boards in a manner that forms a continuous weld with at least one of the conductive metallic paths. As a result, the metal additive structures are continuous with the printed circuit board and do not require separate attachment mechanisms (e.g., soldering or mechanical fastening). The metal additive structures may include shield cans, frames, antennas, or heat sinks for the printed circuit board, for example.