Patents by Inventor Kurt E. Greenizen
Kurt E. Greenizen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11623215Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.Type: GrantFiled: May 10, 2018Date of Patent: April 11, 2023Assignee: EMD Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Patent number: 11433355Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.Type: GrantFiled: April 20, 2017Date of Patent: September 6, 2022Assignee: EMD Millipore CorporationInventors: Kurt E. Greenizen, Christopher A. Scott, Paul Sydlowski, John Doyle, Ryan A. Amara
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Publication number: 20200330981Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.Type: ApplicationFiled: May 10, 2018Publication date: October 22, 2020Inventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Publication number: 20190111395Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.Type: ApplicationFiled: April 20, 2017Publication date: April 18, 2019Inventors: Kurt E. Greenizen, Christopher A. Scott, Paul Sydlowski, John Doyle, Ryan A. Amara
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Patent number: 9891218Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: January 26, 2016Date of Patent: February 13, 2018Assignee: EMD Millipore CorporationInventors: Chris Scott, Phillip Clark, Kurt E. Greenizen, Ryan A. Amara, Robert Colonna
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Patent number: 9751084Abstract: The invention relates to a single use cell culture assembly for use in carrying out bioreactions and growing microorganisms, and tissue and cell cultures. The cell culture assembly is designed to receive an insert having a microscope slide upper surface, and includes a well frame having a plurality of partitioned well compartments, adapted to be positioned on the upper surface of the insert, and includes a liquid-impermeable releasable seal positioned on or within the lower edge of the well frame for maintaining a liquid-impermeable barrier between well compartments.Type: GrantFiled: October 22, 2009Date of Patent: September 5, 2017Assignee: EMD Millipore CorporationInventors: Kurt E. Greenizen, Phillip Clark, John J. Doyle
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Publication number: 20160178625Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: ApplicationFiled: January 26, 2016Publication date: June 23, 2016Inventors: Chris Scott, Phillip Clark, Kurt E. Greenizen, Ryan A. Amara, Robert Colonna
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Patent number: 9272279Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: May 10, 2012Date of Patent: March 1, 2016Assignee: EMD Millipore CorporationInventors: Chris Scott, Phillip Clark, Kurt E. Greenizen, Ryan A. Amara, Robert Colonna
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Publication number: 20140011294Abstract: A rapid, efficient and convenient method to detect one or more biological entities on a blotting membrane is provided. The detection can relate to the position, nature or amount of the biological substance on one or more membranes. The invention method involves a pressure assisted regiment (such as vacuum or positive gas pressure) for the supply and removal of reagents and permits washing of the contaminants from substances embedded in the membrane to be detected using very low volumes of liquid. This method enables completion of the blocking, washing and antibody binding steps in about 30 minutes without comprising blot quality. In another aspect, the invention is directed to an apparatus useful in conducting the method of the invention.Type: ApplicationFiled: September 10, 2013Publication date: January 9, 2014Applicant: EMO Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt E. Greenizen
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Publication number: 20120315189Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: ApplicationFiled: May 10, 2012Publication date: December 13, 2012Applicant: EMD MILLIPORE CORPORATIONInventors: Chris Scott, Phillip Clark, Kurt E. Greenizen, Ryan A. Amara, Robert Colonna
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Patent number: 8007743Abstract: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers.Type: GrantFiled: September 14, 2009Date of Patent: August 30, 2011Assignee: Millipore CorporationInventors: Phil Clark, Kurt E. Greenizen, John Doyle
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Patent number: 7824623Abstract: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein removable inserts with different functionalities can be positioned between a base component and a collar component. The particular inserts chosen depend on the desired sample preparation or assay to be carried out. The inserts are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the multiplate facilitates using vacuum sample processing with automated liquid handlers.Type: GrantFiled: June 24, 2003Date of Patent: November 2, 2010Assignee: Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Publication number: 20100151511Abstract: The invention relates to a resealable or a single use cell culture assembly for use in growing, storing and transporting, cell and tissue cultures. The assembly includes a support frame for receiving a base member insert having an upper surface, such as a microscope slide, and a well frame, preferably partitioned into a plurality of well compartments having sidewalls with upper and lower surfaces, upper and lower edges, and upper and lower well openings. The well frame is adapted to be operatively positioned on the upper surface of the base member, and includes a sealing means positioned on or within the lower edge of the well frame. The sealing means is adapted to operatively create a liquid-impermeable releasable seal or barrier when the lower surface of the well frame is positioned on the upper surface of the base member, such that the sealing means is releasably positioned on the upper surface of the base member for maintaining a liquid-impermeable barrier between well compartments.Type: ApplicationFiled: October 22, 2009Publication date: June 17, 2010Applicant: Millipore CorporationInventors: Kurt E. Greenizen, Phillip Clark, John J. Doyle
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Publication number: 20100009460Abstract: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers.Type: ApplicationFiled: September 14, 2009Publication date: January 14, 2010Applicant: Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Patent number: 7588728Abstract: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers.Type: GrantFiled: February 17, 2004Date of Patent: September 15, 2009Assignee: Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Publication number: 20040266023Abstract: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers.Type: ApplicationFiled: February 17, 2004Publication date: December 30, 2004Inventors: Phillip Clark, Kurt E. Greenizen, John Doyle
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Patent number: D662603Type: GrantFiled: April 2, 2010Date of Patent: June 26, 2012Assignee: EMD Millipore CorporationInventor: Kurt E. Greenizen
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Patent number: D673292Type: GrantFiled: June 18, 2010Date of Patent: December 25, 2012Assignee: EMD Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen
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Patent number: D679829Type: GrantFiled: June 18, 2010Date of Patent: April 9, 2013Assignee: EMD Millipore CorporationInventors: Phillip Clark, Kurt E. Greenizen
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Patent number: D792971Type: GrantFiled: May 5, 2016Date of Patent: July 25, 2017Assignee: EMD Millipore CorporationInventors: Kurt E. Greenizen, Christopher A. Scott, Paul Sydlowski