Patents by Inventor Kurt E. Merkel

Kurt E. Merkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotic A-4696 factor G
    Patent number: 4637981
    Abstract: Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: January 20, 1987
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Kurt E. Merkel, Robert E. Weeks, Gene M. Wild
  • Actaplanin antibiotics
    Patent number: 4558036
    Abstract: Antibiotic A4696 factor H is isolated from the purified antibiotic complex produced by Actinoplanes missouriensis ATCC 31683 and exhibits excellent activity vs. gram-positive bacteria.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: December 10, 1985
    Assignee: Eli Lilly and Company
    Inventor: Kurt E. Merkel
  • Antibiotic M43A, pharmaceutical composition and method of use
    Patent number: 4548925
    Abstract: Antibiotic M43A, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis strains NRRL 2450 and NRRL 2452. M43A has excellent antibacterial activity comparable to that of vancomycin.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 22, 1985
    Assignee: Eli Lilly and Company
    Inventors: Harvey M. Higgins, Jr., Kurt E. Merkel, Mack H. McCormick
  • Antibiotic M43D, pharmaceutical compositions and method of use
    Patent number: 4547488
    Abstract: Antibiotic M43D, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis NRRL 2450. M43D has excellent antibacterial activity comparable to that of vancomycin.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 15, 1985
    Assignee: Eli Lilly and Company
    Inventor: Kurt E. Merkel
  • Actaplanin antibiotics
    Patent number: 4479897
    Abstract: Actaplanin antibiotics (A4696) designated as C.sub.2a, D.sub.1, D.sub.2, K, L, M, N, and O are obtained by the partial acidic hydrolysis of known actaplanins at about pH 1.85 for 2.5 hours at about 90.degree. C. The new actaplanins, like the known actaplanins, are glycopeptides which possess antibacterial activity and, either alone or as a mixture with other actaplanins, improve the feed efficiency in ruminants, swine and poultry.
    Type: Grant
    Filed: April 27, 1983
    Date of Patent: October 30, 1984
    Assignee: Eli Lilly and Company
    Inventors: Ann H. Hunt, Kurt E. Merkel
  • Antibiotic A-4696 factor G
    Patent number: 4461723
    Abstract: Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: July 24, 1984
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Kurt E. Merkel, Robert E. Weeks, Gene M. Wild
  • Biologically pure culture of Actinoplanes missouriensis
    Patent number: 4375513
    Abstract: Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3, and E.sub.1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p.sup.H 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: March 1, 1983
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Kurt E. Merkel, Robert E. Weeks, Herald J. Cole
  • Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3 and E.sub.1
    Patent number: 4322406
    Abstract: Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3, and E.sub.1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p.sup.H 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.
    Type: Grant
    Filed: December 18, 1980
    Date of Patent: March 30, 1982
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Kurt E. Merkel, Robert E. Weeks, Herald J. Cole