Patents by Inventor Kurt Eichenberger
Kurt Eichenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4808603Abstract: Compounds of the formula ##STR1## in which R represents a carbocyclic or heterocyclic aryl radical, R.sub.1 represents lower alkyl, one of the groups R.sub.2 and R.sub.3 represents lower alkyl and the other represents lower alkyl, cyano aor amino, X represents oxygen or the group --NH--, Alk.sub.1 represents lower alkylene or optionally substituted phenyl-lower alkylene, which separates the group X from the nitrogen atom by at least two carbon atoms, R.sub.4 represents hydrogen, lower alkyl or optionally substituted phenyl-lower alkyl, Z represents the group --(C.dbd.O)-- or a single bond, Alk.sub.2 represents lower alkylene which separates the groups Z and Y preferably by from 2 to 4 carbon atoms, Y represents the group --(C.dbd.O)-- and Ar.sub.1 represents a monocyclic, carbocyclic or heterocyclic aryl radical, and salts of such compounds having salt-forming properties, have cardiovascular properties, especially coronary dilatory and anti-hypertensive properties.Type: GrantFiled: August 7, 1986Date of Patent: February 28, 1989Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Hans Kuhnis
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Patent number: 4616002Abstract: Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR.sub.7 or --NR.sub.8 R.sub.9, R.sub.1 represents hydrogen, unsubstituted or substituted lower alkyl, a carbocyclic or heterocyclic aryl radical or free, etherified or esterified hydroxy, R.sub.2 and R.sub.3, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl, formyl or functionally modified formyl, carboxy or functionally modified carboxy, a carbocyclic or heterocyclic aryl radical or unsubstituted or mono- or di-substituted amino, R.sub.4 represents hydrogen or lower alkyl, R.sub.5 and R.sub.6, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl or a carbocyclic or heterocyclic aryl radical, R.sub.7, R.sub.8 and R.sub.Type: GrantFiled: January 6, 1986Date of Patent: October 7, 1986Assignee: Ciba-Geigy CorporationInventors: Bruno Kamber, Thomas Leutert, Hans Kuhnis, Kurt Eichenberger
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Patent number: 4304912Abstract: Piperidines of the formula ##STR1## in which R.sub.1 is a substituted or unsubstituted heteroaryl radical, alk.sub.1 and alk.sub.2 independently of one another are lower alkylene radicals, each of which separates by 2 carbon atoms the nitrogen atom bonded thereto from the methane group bonded thereto, R.sub.2 is a free or acylated hydroxyl group, Ph is a substituted or unsubstituted o-phenylene radical, n is 0 or 1, R.sub.3 is a hydrogen atom, a lower alkyl radical or a hydroxyl group and R.sub.5 is a lower alkyl radical or a hydrogen atom, or R.sub.3 and R.sub.5 together are a second bond and R.sub.4 and R.sub.6 are each a hydrogen atom, or R.sub.4 together with R.sub.3 is an oxo group, R.sub.5 is a lower alkyl radical or a hydrogen atom and R.sub.6 is a hydrogen atom, or R.sub.6 together with R.sub.5 is an oxo group, R.sub.3 is a hydrogen atom, a lower alkyl radical or a hydroxyl group and R.sub.4 is a hydrogen atom, or salts thereof are antihypertensive and antiarrhythmic agents.Type: GrantFiled: December 10, 1979Date of Patent: December 8, 1981Assignee: Ciba-Geigy CorporationInventors: Herbert Schroter, Kurt Eichenberger, Hans Kuhnis, Christian Egli, Oswald Schier, Franz Ostermayer
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Patent number: 4264599Abstract: The invention relates to novel piperidino-propanols, especially 1-(3-heterocyclyloxy-2-hydroxy-propanol)-4-(N-diazcyclyl)-piperidines of the formula ##STR1## in which R.sub.1 is a substituted or unsubstituted heteroaryl radical, R.sub.2 is hydrogen or a substituted or unsubstituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic hydrocarbon radical or an acyl radical and alk is lower alkylene which separates the two nitrogen atoms from one another by 2 or 3 carbon atoms, or is a substituted or unsubstituted 1,2-phenylene radical, and salts thereof, as well as processes for their preparation, and also to pharmaceutical preparations containing these compounds and the use thereof, preferably in the form of pharmaceutical preparations as antihypertensive agents, antitachycardiac agents and .alpha.-sympathicolytic agents.Type: GrantFiled: July 3, 1978Date of Patent: April 28, 1981Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Hans Kuhnis, Franz Ostermayer, Herbert Schroter
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Patent number: 4217350Abstract: A process known per se for the manufacture of oxygenated N-aryl-diazacyclic compounds of the formula ##STR1## wherein each of R.sub.1 and R.sub.2 represents a substituted or unsubstituted aryl group and alk represents a lower alkylene group which separates both nitrogen atoms from each other by 2 or 3 carbon atoms, or salts thereof.The novel compounds can be used as antihypertensives, antitachycardiac agents and .alpha.-receptor blockers.Type: GrantFiled: December 22, 1978Date of Patent: August 12, 1980Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Hans Kuhnis, Franz Ostermayer, Herbert Schroter
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Patent number: 4185110Abstract: Novel benzoheterocyclylglyoxylic acid derivatives of the formula ##STR1## in which Z is free, etherified or acylated hydroxyl, X is thio or oxy, R is free or etherified hydroxyl, R.sub.1 is lower alkyl, cycloalkyl, hydroxyl, lower alkoxy, substituted or unsubstituted phenoxy, substituted or unsubstituted amino, acyl, carboxyl, halogen, nitro or, if Z is acylated hydroxyl and/or X is oxy, hydrogen, R.sub.2 is hydrogen, lower alkyl, hydroxyl or halogen and R.sub.3 and R.sub.4 are each hydrogen or lower alkyl, or in which two adjacent radicals R.sub.1, R.sub.2, R.sub.3 and R.sub.4 together form lower alkylene having 3 to 5 chain carbon atoms or 1,4-butadienylene and the other two radicals are each hydrogen, and their pharmaceutically acceptable salts are useful as anti-allergic agents.Type: GrantFiled: February 9, 1978Date of Patent: January 22, 1980Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Hans Bosshard, Niklaus Buhler, Richard Goschke, Knut A. Jaeggi
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Patent number: 4144344Abstract: A process known per se for the manufacture of oxygenated N-aryl-diazacyclic compounds of the formula ##STR1## wherein EACH OF R.sub.1 and R.sub.2 represents a substituted or unsubstituted aryl group and alk represents a lower alkylene group which separates both nitrogen atoms from each other by 2 or 3 carbon atoms, or salts thereof.The novel compounds can be used as antihypertensives, antitachycardiac agents and .alpha.-receptor blockers.Type: GrantFiled: January 21, 1977Date of Patent: March 13, 1979Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Hans Kuhnis, Franz Ostermayer, Herbert Schroter
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Patent number: 4075335Abstract: Piperidines of the formula ##STR1## in which R.sub.1 stands for optionally substituted aryl, R.sub.2 for hydrogen, lower alkyl, lower alkenyl, acyl or .alpha.-aryl-lower alkyl, R.sub.3 for a free or substituted hydroxyl group, alk for lower alkylene which separates the two nitrogen atoms by 2 or 3 carbon atoms, R.sub.4 represents hydrogen or lower alkyl and n represents an integer from 1 to 4, and their salts as well as processes for their manufacture and pharmaceutical compositions comprising such compounds, and a process for lowering the blood pressure wherein such compositions are administered to a warm-blooded host.Type: GrantFiled: January 28, 1976Date of Patent: February 21, 1978Assignee: Ciba-Geigy CorporationInventors: Max Wilhelm, Kurt Eichenberger, Herbert Schroter, Franz Ostermayer
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Patent number: 4075208Abstract: Piperidines of the formula ##STR1## in which R.sub.1 stands for optionally substituted aryl, R.sub.2 for hydrogen, lower alkyl, lower alkenyl, acyl or .alpha.-aryl-lower alkyl, R.sub.3 for a free or substituted hydroxyl group, alk for lower alkylene which separates the two nitrogen atoms by 2 or 3 carbon atoms, R.sub.4 represents hydrogen or lower alkyl and n represents an integer from 1 to 4, and their salts as well as processes for their manufacture and pharmaceutical compositions comprising such compounds, and a process for lowering the blood pressure wherein such compositions are administered to a warm-blooded host.Type: GrantFiled: January 28, 1976Date of Patent: February 21, 1978Assignee: Ciba-Geigy CorporationInventors: Max Wilhelm, Kurt Eichenberger, Herbert Schroter, Franz Ostermayer
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Patent number: 4029795Abstract: 1-(3-Aryloxy-2-hydroxypropyl)-4-(1-oxoisoquinolino)-piperidines, e.g. those of the formula ##STR1## R' = H, alkanoylaminoethenyl, carbamoyl, alkanoyl, CN, alkoxycarbonylamino-lower alkyl, halo, OH, alkanoylamino, alkyl, alkoxy, alkenyl, alkenyloxyR" = H, alkyl, alkoxy, alkenyl, alkenyloxy,R'" = alkanoylamino, NH.sub.2, NO.sub.2, alkyl, alkoxy, halo CF.sub.3, OH2-alkanoic acid esters and acid addition salts thereof are antihypertensive and antiarrhythmic agents.Type: GrantFiled: July 14, 1975Date of Patent: June 14, 1977Assignee: Ciba-Geigy CorporationInventors: Kurt Eichenberger, Christian Egli, Hans Kuhnis, Oswald Schier
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Patent number: 3998955Abstract: Pyridines of the formula I ##STR1## wherein R.sub.1 is free hydroxyl, lower alkoxy, cycloalkoxy, amino-lower alkoxy or lower alkoxy-lower alkoxy, free amino, hydroxyamino, lower alkyleneamino, oxa-, aza- or thia-lower alkyleneamino or mono- or di-lower alkylamino, R.sub.2 is oxygen or sulphur, R.sub.3 and R.sub.4 are each alkoxy, free amino, mono- or di-lower alkylamino, lower alkyleneamino, oxa-, aza- or thia-lower alkyleneamino, halogen or free hydroxyl, and either R.sub.3 or R.sub.4 can be hydrogen, and alk is an alkyl group with 3-10 carbon atoms, and their N-oxides, and salts are useful as dopamine-.beta.-hydroxylase inhibitors.Type: GrantFiled: April 16, 1975Date of Patent: December 21, 1976Assignee: Ciba-Geigy CorporationInventors: Hans Kuhnis, Christian Egli, Kurt Eichenberger, Phyllis Roberta Hedwall
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Patent number: 3956335Abstract: Piperidines of the formula ##SPC1##In which R.sub.1 stands for optionally substituted aryl, R.sub.2 for hydrogen, lower alkyl, lower alkenyl, acyl or .alpha.-aryl-lower alkyl, R.sub.3 for a free or substituted hydroxyl group, alk for lower alkylene which separates the two nitrogen atoms by 2 or 3 carbon atoms, R.sub.4 represents hydrogen or lower alkyl and n represents an integer from 1 to 4, and their salts as well as processes for their manufacture and pharmaceutical compositions comprising such compounds, and a process for lowering the blood pressure wherein such compositions are administered to a warm-blooded host.Type: GrantFiled: June 27, 1974Date of Patent: May 11, 1976Assignee: Ciba-Geigy CorporationInventors: Max Wilhelm, Kurt Eichenberger, Herbert Schroter, Franz Ostermayer