Patents by Inventor Kurt Hilpert

Kurt Hilpert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole carboxamide derivatives as P2X7 receptor antagonist
    Patent number: 9718774
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: August 1, 2017
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • Indole carboxamide derivatives as P2Xreceptor antagonists
    Patent number: 9556117
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: January 31, 2017
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9409917
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 9, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9388197
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 12, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2Xreceptor antagonists
    Patent number: 9388198
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 12, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9221832
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 29, 2015
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm, Mark Murphy
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150361097
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 17, 2015
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150361096
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 17, 2015
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150344425
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: December 17, 2013
    Publication date: December 3, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
    Publication number: 20150322008
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: December 11, 2013
    Publication date: November 12, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: KURT HILPERT, FRANCIS HUBLER, THIERRY KIMMERLIN, DORTE RENNEBERG, SIMON STAMM
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150025075
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 22, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20140163035
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: July 20, 2012
    Publication date: June 12, 2014
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm, Mark Murphy
  • BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20140073651
    Abstract: The invention relates to benzamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: February 21, 2012
    Publication date: March 13, 2014
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Kurt Hilpert, Francis Hubler, Mark Murphy, Dorte Renneberg
  • Thiazole derivatives and their use as P2Y12 receptor antagonists
    Patent number: 8664203
    Abstract: The present invention relates to thiazole derivatives of formula I and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: March 4, 2014
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Eva Caroff, Kurt Hilpert, Francis Hubler, David Lehmann, Emmanuel Meyer, Dorte Renneberg
  • THIAZOLE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS
    Publication number: 20130281406
    Abstract: The present invention relates to thiazole derivatives of Formula (I) and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 24, 2013
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Eva CAROFF, Kurt HILPERT, Francis HUBLER, David LEHMANN, Emmanuel MEYER, Dorte RENNEBERG
  • Phosphonic acid derivates and their use as P2Yreceptor antagonists
    Patent number: 8518912
    Abstract: The invention relates to 2-phenyl-pyrimidine derivatives containing a phosphonic acid motif and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. (I).
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: August 27, 2013
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Eva Caroff, Kurt Hilpert, Francis Hubler, Emmanuel Meyer, Dorte Renneberg
  • Salts of isobutyric acid (1 R*, 2R*, 4R*)-2-(2-{[3-(4,7-dimethoxy-1 H-benzoimidazol-2-yl)-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester
    Patent number: 8492555
    Abstract: The invention relates to crystalline salts of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7 -dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester, processes for the preparation thereof, pharmaceutical compositions containing said crystalline salts, and their use as medicaments, especially as calcium channel blockers.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: July 23, 2013
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Stefan Abele, Stéphanie Combes, Jacques-Alexis Funel, Kurt Hilpert, Francis Hubler, Katharina Reichenbaecher, Dorte Renneberg, Markus Von Raumer
  • Tetrahydronaphthalene compounds
    Patent number: 8436205
    Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: May 7, 2013
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg
  • Bridged tetrahydronaphthalene derivatives
    Patent number: 8314253
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, A, B, W and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: November 20, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg
  • 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines
    Patent number: 8288385
    Abstract: The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: October 16, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Eva Caroff, Kurt Hilpert, Francis Hubler, Emmanuel Meyer, Dorte Renneberg