Abstract: Techniques, systems, and assemblies are presented relating to micro spacers positioned between optical substrates. In some embodiments, a stacked optical assembly comprises a first optical substrate having a first index of refraction greater than 1.4, a second optical substrate having a second index of refraction greater than 1.4 and disposed in a stacked position relative to the first optical substrate, and a plurality of micro spacers positioned between the first optical substrate and the second optical substrate. The plurality of micro spacers may maintain a gap having a gap height between the first optical substrate and the second optical substrate. The plurality of micro spacers may be fixedly attached to (a) the first optical substrate, (b) the second optical substrate, or (c) both the first optical substrate and the second optical substrate.

Abstract: According to examples, a lens configuration for a head-mounted display (HMD) device may include a base platform made from glass or plastic, an antenna layer deposited onto the base platform, an optical polymer film deposited onto the antenna layer, and a lens layer deposited onto the optical polymer film through a 3D printing technique. The antenna layer may include a transparent antenna embedded into or deposited onto a transparent layer. The lens layer may be 3D printed as multiple partial layers to have a shape that matches a prescription for the lens layer.

Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.

Abstract: The disclosed apparatus may include a first rigid lens; a second rigid lens, a seal that couples the first rigid lens and the second rigid lens together, where the first rigid lens, the second rigid lens, and the seal define a cavity; and a fluid within the cavity, where the seal is adapted to admit expansions of the fluid within the cavity. Various other apparatuses and methods also disclosed.

Abstract: Methods, systems, and apparatuses for creating or using a multi-layer lens. The processor may create a first layer lens, cool the first layer lens, and combine the first layer lens with a second layer lens to create a multi-layer lens.

Abstract: A device is provided. The device includes a reflective polarizer configured to selectively reflect or transmit a polarized light based on a polarization of the polarized light. The device also includes a display element disposed at a first side of the reflective polarizer, and configured to output a first image light representing a virtual image. The device also includes a polarization switch disposed between the display element and the reflective polarizer, and configured to switch or maintain a polarization of the first image light. The device further includes an active dimming device disposed at a second side of the reflective polarizer, and configured to provide an adjustable transmittance of an input light.

Abstract: The present invention relates to targeted, masked cytokines, comprising a cytokine or functional fragment thereof, a masking moiety, a targeting moiety and a proteolytically cleavable linker. The targeting moiety comprises an antigen-binding moiety that specifically binds to an antigen expressed on the surface of a target cell The masking moiety masks the cytokine or functional fragment thereof thereby reducing or preventing binding of the cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

Abstract: According to examples, a lens configuration for a head-mounted display (HMD) device may include a base platform made from glass or plastic, an antenna layer deposited onto the base platform, an optical polymer film deposited onto the antenna layer, and a lens layer deposited onto the optical polymer film through a 3D printing technique. The antenna layer may include a transparent antenna embedded into or deposited onto a transparent layer. The lens layer may be 3D printed as multiple partial layers to have a shape that matches a prescription for the lens layer.

Abstract: A corrected optical lens includes an inner layer that includes a low stress optical lens and an outer layer that includes one or more corrective layers. The outer layer may be formed on at least a portion of an outer surface of the inner layer by scanning the outer surface of the inner layer, generating a surface characterization file based on the outer surface scan, and 3D printing the one or more corrective layers on the outer surface of the inner layer based on the surface characterization file as input to a 3D printer. The surface characterization file may be corrected based on a particular predetermined contour of the inner layer prior to being input to the 3D printer. The correction may include, for example, reduction of root mean square (RMS) values of deviations of detected peaks and valleys on the surface of the inner layer.

Abstract: A device is provided. The device includes a reflective polarizer configured to selectively reflect or transmit a polarized light based on a polarization of the polarized light. The device also includes a display element disposed at a first side of the reflective polarizer, and configured to output a first image light representing a virtual image. The device also includes a polarization switch disposed between the display element and the reflective polarizer, and configured to switch or maintain a polarization of the first image light. The device further includes an active dimming device disposed at a second side of the reflective polarizer, and configured to provide an adjustable transmittance of an input light.

Abstract: An optical assembly includes an optically transparent substrate and a first lens removably coupled with the optically transparent substrate by one or more adhesive layers. The one or more adhesive layers are positioned between the optically transparent substrate and the first lens. Also disclosed are an eye-tracker and a display device, each of which includes the optical assembly.

Abstract: A headset for augmented reality applications is provided. The headset includes at least one eyepiece configured to provide a see-through image to a user via a transparent optical component, and to provide an artificial image through a display, and a dimming shutter configured to adjust a transparency level of the transparent optical component. The dimming shutter further includes an active liquid crystal layer configured to adjust a transparency level according to an electrical power provided between two electrodes, and a photoactive layer configured to adjust the transparency level upon absorption of an ultraviolet radiation for a selected period of time. A default orientation of a host material in the active liquid crystal layer may be in a dark state or in a clear state, when no electrical power is provided. A method and a memory storing instructions to execute the method for use of the above device are also provided.

Abstract: A lens includes a glass layer and a plastic layer. The glass layer has a first glass side disposed opposite of a second glass side. The plastic layer has a first plastic side disposed opposite of a second plastic side. The first plastic side of the plastic layer is bonded to the second glass side of the glass layer. The outside plastic boundary of the plastic layer extends past an outside glass boundary of the glass layer.

Abstract: A pair of moulds for moulding an optical component is disclosed. The pair of moulds includes a first mould having a first surface, and a second mould having a second surface. The first surface includes a moulding portion for moulding a first optical surface of the optical component, and an alignment portion for alignment with the second mould. The alignment portion extends around the moulding portion. The second surface includes a moulding portion for moulding a second, opposite optical surface of the optical component, and an alignment portion for alignment with the first mould via a contact with the alignment portion of the first surface. When the moulds are brought together, they self-align. A corresponding moulding apparatus and a method may use the mould pair to manufacture various optical components.

Abstract: Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4).

Abstract: A method of making a customized lens includes providing a first substrate having a first surface, the first surface being a non-flat surface; placing an optical film in contact with the first surface; bringing a layer of a first material into contact with the optical film; and curing the layer of the first material to form a lens. The optical film has a lower surface roughness than the first surface.

Abstract: A method for manufacturing thin, multi-bend optics includes placing an optical substrate and a protective sheet into a compression mold and closing the compression mold to deform the optical substrate and to deform the protective sheet. The optical substrate can include an optical surface and the protective sheet can be disposed between the compression mold and the optical surface of the optical substrate. The compression mold can include a mold contact surface that is characterized by a surface roughness. The compression mold can be held in a closed position for a compression time period, during which, the protective sheet contacts the mold contact surface and provides a buffer layer between the mold contact surface and the optical surface thereby mitigating against transfer of the surface roughness of the mold contact surface onto the optical surface.

Abstract: A method includes placing an optical substrate onto a vacuum mold having a bent contact surface characterized by a surface roughness. The method further includes bending, by an applied bending force, the optical substrate and the protective sheet to cause the protective sheet to come into contact with the bent contact surface of the vacuum mold, generating a vacuum-induced holding force to hold the protective sheet against the bent contact surface of the vacuum mold. After a holding time period, the vacuum-induced holding force is released. During molding, a protective sheet provides a buffer layer between the bent contact surface of the vacuum mold and an optical surface of the optical substrate thereby mitigating against transfer of the surface roughness of the bent contact surface onto the optical surface.

Abstract: An optical assembly includes an optically transparent substrate and a first lens removably coupled with the optically transparent substrate by one or more adhesive layers. The one or more adhesive layers are positioned between the optically transparent substrate and the first lens. Also disclosed are an eye-tracker and a display device, each of which includes the optical assembly.

Abstract: A heat management device able to be manufactured using 3-D printing and corresponding to a body of a head mounted display system having an outer wall that partially encloses a chamber. The outer wall of the heat management device comprises a plurality of channels that traverse a thickness of the outer wall, each channel shaped to allow air to flow between the interior and exterior of the chamber, while preventing light from outside the chamber from entering the chamber. In some embodiments, each channel may be shaped to comprise a first portion and a second portion connected at an acute angle, the connection between the first and second portions serving to block a direct path for light to traverse between the ends of the channel.