Patents by Inventor Kurt L. Wachholder

Kurt L. Wachholder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester using L-&agr;-aspartyl-L-phenylalanine 1-methyl ester precursors
    Patent number: 6642406
    Abstract: N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 4, 2003
    Assignee: The NutraSweet Company
    Inventors: Indra Prakash, Zhi Guo, Steve Schroeder, Kurt L. Wachholder
  • Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using L-alpha-aspartyl-L- phenylalanine 1-methyl ester precursors
    Publication number: 20020019557
    Abstract: N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
    Type: Application
    Filed: May 18, 2001
    Publication date: February 14, 2002
    Inventors: Indra Prakash, Zhi Guo, Steve Schroeder, Kurt L. Wachholder
  • Basic salts of n-[n-(3,3-dimethylbutyl)-l-&agr;-aspartyl]-l-phenylalanine 1-methyl ester
    Patent number: 6291004
    Abstract: Dipeptide sweeteners are disclosed that are basic salts of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula wherein Xm+ is selected from the group consisting of Na+, K+, Al3+, Fe2+, Fe3+, Ca2+, Mg2+, NH4+ and Zn2+; Qs− absent or a physiologically acceptable counter anion; and m−s=n. Also disclosed is a liquid low-calorie sweetener containing such basic salts.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: September 18, 2001
    Assignee: The NutraSweet Company
    Inventors: Indra Prakash, Kurt L. Wachholder
  • Synthesis of N-(N-(3,3-dimethylbutyl)-L-&agr;-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
    Patent number: 6281380
    Abstract: N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by reductive alkylation and crystallization/isolation in methanol and water. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis and results in high purity N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: August 28, 2001
    Assignee: The Nutra Sweet Company
    Inventors: Indra Prakash, Mike G. Scaros, Kurt L. Wachholder
  • Acid salts of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester
    Patent number: 6180156
    Abstract: Dipeptide sweeteners are disclosed that are salts of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula wherein X− is selected from the group consisting of Cl−, HSO4−, H2PO3−, citrate, HCO3−, furmarate, malate, maleiate, tartarate, acetate, benzoate or gluconate. Also disclosed is a liquid low-calorie sweetener containing such salts.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: January 30, 2001
    Assignee: The NutraSweet Company
    Inventors: Indra Prakash, Kurt L. Wachholder